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'''Csaba Pal''' (Hungarian: Pál [ˈpaːl] Csaba [ˈt͡ʃɒbɒ], born March 27, 1975)<ref>{{cite web |title=BRC Csaba PÁL D.Sc. |url=http://www.brc.hu/personal_page.php?id=bk_p%C3%A1cs |website=www.brc.hu |accessdate=29 January 2020}}</ref><ref name=BRCCV>{{cite web |title=BRC Csaba PÁL CV |url=http://www.brc.hu/file/cv/biochem_pal_csaba_en.pdf |accessdate=29 January 2020}}</ref> is a Hungarian biologist at the Biological Research Centre (BRC)<ref>{{cite web |title=BRC |url=http://www.brc.hu |website=www.brc.hu |accessdate=28 January 2020}}</ref> in Szeged Hungary. His laboratory is part of the Synthetic and Systems Biology Unit at BRC.<ref>{{cite web |title=BRC Synthetic and Systems Biology Unit |url=http://www.brc.hu/biochem_synthetic_systems_biology_unit.php |website=www.brc.hu |accessdate=29 January 2020}}</ref><ref>{{cite web |title=Csaba Pál Laboratory |url=http://group.szbk.u-szeged.hu/sysbiol/pal-csaba-lab-index.html |website=group.szbk.u-szeged.hu |accessdate=28 January 2020}}</ref> His research is at the interface of evolution, antibiotic resistance and genome engineering<ref name=Heidelberg>{{cite web |title=New members greeted in Heidelberg |url=https://www.embo.org/news/articles/2018/new-members-greeted-in-heidelberg |website=EMBO |accessdate=19 December 2018 |language=en-gb}}</ref><ref name=FEMS>{{cite web |title=FEMS Expert: Dr Csaba Pal |url=https://fems-microbiology.org/network/leading_opinion_in_science/eam-members/fems-expert-dr-csaba-pal/ |website=FEMS |accessdate=29 January 2020}}</ref> and has published over 70 scientific publications in these areas.<ref>{{cite web |title=Magyar Tudományos Művek Tára |url=https://m2.mtmt.hu/gui2/?type=authors&mode=browse&sel=10027825&view=pubTable |website=m2.mtmt.hu |accessdate=31 January 2020}}</ref><ref>{{cite web |title=Csaba Pal - Google Scholar Citations |url=https://scholar.google.hu/citations?user=9VUsiHMAAAAJ&hl=en |website=scholar.google.hu |accessdate=31 January 2020}}</ref>
'''Csaba Pal''' (Hungarian: Pál [ˈpaːl] Csaba [ˈt͡ʃɒbɒ], born March 27, 1975)<ref>{{cite web |title=BRC Csaba PÁL D.Sc. |url=http://www.brc.hu/personal_page.php?id=bk_p%C3%A1cs |website=www.brc.hu |accessdate=29 January 2020}}</ref><ref name=BRCCV>{{cite web |title=BRC Csaba PÁL CV |url=http://www.brc.hu/file/cv/biochem_pal_csaba_en.pdf |accessdate=29 January 2020}}</ref> is a Hungarian biologist at the [[Biological Research Centre]] (BRC)<ref>{{cite web |title=BRC |url=http://www.brc.hu |website=www.brc.hu |accessdate=28 January 2020}}</ref> in Szeged Hungary. His laboratory is part of the [[Synthetic biology|Synthetic]] and [[Systems Biology]] Unit at BRC.<ref>{{cite web |title=BRC Synthetic and Systems Biology Unit |url=http://www.brc.hu/biochem_synthetic_systems_biology_unit.php |website=www.brc.hu |accessdate=29 January 2020}}</ref><ref>{{cite web |title=Csaba Pál Laboratory |url=http://group.szbk.u-szeged.hu/sysbiol/pal-csaba-lab-index.html |website=group.szbk.u-szeged.hu |accessdate=28 January 2020}}</ref> His research is at the interface of [[evolution]], [[antibiotic resistance]] and [[genome engineering]]<ref name=Heidelberg>{{cite web |title=New members greeted in Heidelberg |url=https://www.embo.org/news/articles/2018/new-members-greeted-in-heidelberg |website=EMBO |accessdate=19 December 2018 |language=en-gb}}</ref><ref name=FEMS>{{cite web |title=FEMS Expert: Dr Csaba Pal |url=https://fems-microbiology.org/network/leading_opinion_in_science/eam-members/fems-expert-dr-csaba-pal/ |website=FEMS |accessdate=29 January 2020}}</ref> and has published over 70 scientific publications in these areas.<ref>{{cite web |title=Magyar Tudományos Művek Tára |url=https://m2.mtmt.hu/gui2/?type=authors&mode=browse&sel=10027825&view=pubTable |website=m2.mtmt.hu |accessdate=31 January 2020}}</ref><ref>{{cite web |title=Csaba Pal - Google Scholar Citations |url=https://scholar.google.hu/citations?user=9VUsiHMAAAAJ&hl=en |website=scholar.google.hu |accessdate=31 January 2020}}</ref>


==Education==
==Education==


Csaba Pal completed his Masters in Biology at Eötvös Loránd University, Budapest, in 1998.<ref name=BRCCV/><ref name=AcademiaEuropaeaCV>{{cite web |title=Academy of Europe: CV |url=https://www.ae-info.org/ae/Member/P%C3%A1l_Csaba/CV |website=www.ae-info.org |accessdate=29 January 2020}}</ref> Four years later he was awarded a Doctor of Philosophy degree from the Eötvös Loránd University, Budapest in 2002.<ref name=BRCCV/><ref name=AcademiaEuropaeaCV/> In 2018 he received a Doctor of Science degree from the Hungarian Academy of Sciences.<ref name=BRCCV/>
Csaba Pal completed his Masters in Biology at [[Eötvös Loránd University]], [[Budapest]], in 1998.<ref name=BRCCV/><ref name=AcademiaEuropaeaCV>{{cite web |title=Academy of Europe: CV |url=https://www.ae-info.org/ae/Member/P%C3%A1l_Csaba/CV |website=www.ae-info.org |accessdate=29 January 2020}}</ref> Four years later he was awarded a Doctor of Philosophy degree from the [[Eötvös Loránd University]], [[Budapest]] in 2002.<ref name=BRCCV/><ref name=AcademiaEuropaeaCV/> In 2018 he received a [[Doctor of Science]] degree from the [[Hungarian Academy of Sciences]].<ref name=BRCCV/>
Csaba Pal spent several years abroad with scholarships. He had the opportunity to research in Bath,<ref>{{cite web |title=Students and post-docs past and present |url=https://people.bath.ac.uk/bssldh/LaurenceDHurst/Lab_members.html |website=people.bath.ac.uk |accessdate=28 January 2020}}</ref> Oxford, Heidelberg and Italy.<ref name=BRCCV/><ref name=AcademiaEuropaeaCV/> Prior to his return to Hungary in 2008, he worked as a visiting scientist at the University of Trento.<ref name=BRCCV/><ref name=AcademiaEuropaeaCV/>
Csaba Pal spent several years abroad with scholarships. He had the opportunity to research in Bath,<ref>{{cite web |title=Students and post-docs past and present |url=https://people.bath.ac.uk/bssldh/LaurenceDHurst/Lab_members.html |website=people.bath.ac.uk |accessdate=28 January 2020}}</ref> Oxford, Heidelberg and Italy.<ref name=BRCCV/><ref name=AcademiaEuropaeaCV/> Prior to his return to Hungary in 2008, he worked as a visiting scientist at the University of Trento.<ref name=BRCCV/><ref name=AcademiaEuropaeaCV/>


Revision as of 08:44, 2 June 2020

Csaba Pal (Hungarian: Pál [ˈpaːl] Csaba [ˈt͡ʃɒbɒ], born March 27, 1975)[1][2] is a Hungarian biologist at the Biological Research Centre (BRC)[3] in Szeged Hungary. His laboratory is part of the Synthetic and Systems Biology Unit at BRC.[4][5] His research is at the interface of evolution, antibiotic resistance and genome engineering[6][7] and has published over 70 scientific publications in these areas.[8][9]

Education

Csaba Pal completed his Masters in Biology at Eötvös Loránd University, Budapest, in 1998.[2][10] Four years later he was awarded a Doctor of Philosophy degree from the Eötvös Loránd University, Budapest in 2002.[2][10] In 2018 he received a Doctor of Science degree from the Hungarian Academy of Sciences.[2] Csaba Pal spent several years abroad with scholarships. He had the opportunity to research in Bath,[11] Oxford, Heidelberg and Italy.[2][10] Prior to his return to Hungary in 2008, he worked as a visiting scientist at the University of Trento.[2][10]

Career and research

Csaba Pal works on fundamental and applied problems in the evolution of genomes networks and antibiotic resistance.[6] To achieve these goals, he develops methods in systems biology, computational metabolic modelling and genome engineering.

Genome evolution

In 2001, Csaba Pal and colleagues demonstrated that highly expressed genes in yeast evolve slowly.[12] Later, they argued that evolutionary rate of a protein is predominantly influenced by its expression level rather than functional importance. This research has contributed to a paradigmatic shift in the field of protein evolution.[13][14] Balazs Papp, Csaba Pal, and Laurence Hurst studied molecular mechanisms underlying dosage sensitivity.[15] They specifically tested what is now known as the dosage balance hypothesis.[16] The hypothesis offers a synthesis on seemingly unrelated problems such as the evolution of dominance, gene duplicability and co-evolution of protein complex subunits. In 2007, Pal and colleagues demonstrated that antagonistic co-evolution with parasites has a large impact on the evolution of bacterial mutation rate.[17] This paper showed how biotic interactions shape mutation rate evolution.

More recently, the Pal lab explored the consequences of compensatory adaptation on gene content evolution.[18] It is well known that while core cellular processes are generally conserved during evolution, the underlying genes differ somewhat between related species. They demonstrated that gene loss initiates adaptive genomic changes that rapidly restores fitness, but this process has substantial pleiotropic effects on cellular physiology and evolvability upon environmental change.[19]

Network evolution

The Pal lab has also contributed to the nascent field of evolutionary systems biology.[20] Their research focused on understanding the extent to which evolution is predictable at the molecular level. Using genome-scale metabolic network modeling combined with experimental tools they studied key issues in evolution, such as mutational robustness,[21] horizontal gene transfer,[22] genome reduction,[23] epistasis,[24][25] promiscuous enzyme reactions,[26] and complex adaptations.[27]

Antibiotic resistance

Csaba Pal's laboratory currently studies the problem of antibiotic resistance. By combining laboratory evolution, genome sequencing, and functional analyses, they charted the map of evolutionary trade-offs between antibiotics. They found that multidrug resistance mutations in bacteria simultaneously enhance sensitivity to many other unrelated drugs (collateral sensitivity), and explored the underlying molecular mechanisms.[28]

Genome engineering

Finally, the Pal lab is an advocate of the emerging field of evolutionary genome engineering.[29][30] Genome engineering enables the modification of specific genomic locations in a directed and combinatorial manner, and allow studying central evolutionary issues in which natural genetic variation is limited or biased. However, current tools have been optimized for a few laboratory model strains, lead to the accumulation of numerous undesired, off-target modifications, and demand extensive modification of the host genome prior to large-scale editing. The Pal laboratory presented a simple, all-in-one solution.[31][32] The method is unique as it allows systematic comparison of mutational effects and epistasis across a wide range of bacterial species.

Awards and honours

Csaba Pal received several domestic and international awards, including the Ignaz Lieben Award (2009),[33][34] Szent-György Talentum Prize (2014),[35] and the Bolyai Prize (2015).[36][37][38][39] In 2016, Csaba Pal became member of Academiae Europae.[40] In 2017 he was selected as EMBO (European Molecular Biology Organization) member.[41][42] and in 2018, became a member of the FEMS. (Federation of European Microbiological Society)[7]

References

  1. ^ "BRC Csaba PÁL D.Sc". www.brc.hu. Retrieved 29 January 2020.
  2. ^ a b c d e f "BRC Csaba PÁL CV" (PDF). Retrieved 29 January 2020.
  3. ^ "BRC". www.brc.hu. Retrieved 28 January 2020.
  4. ^ "BRC Synthetic and Systems Biology Unit". www.brc.hu. Retrieved 29 January 2020.
  5. ^ "Csaba Pál Laboratory". group.szbk.u-szeged.hu. Retrieved 28 January 2020.
  6. ^ a b "New members greeted in Heidelberg". EMBO. Retrieved 19 December 2018.
  7. ^ a b "FEMS Expert: Dr Csaba Pal". FEMS. Retrieved 29 January 2020.
  8. ^ "Magyar Tudományos Művek Tára". m2.mtmt.hu. Retrieved 31 January 2020.
  9. ^ "Csaba Pal - Google Scholar Citations". scholar.google.hu. Retrieved 31 January 2020.
  10. ^ a b c d "Academy of Europe: CV". www.ae-info.org. Retrieved 29 January 2020.
  11. ^ "Students and post-docs past and present". people.bath.ac.uk. Retrieved 28 January 2020.
  12. ^ Hurst, Laurence D.; Papp, Balázs; Pál, Csaba (June 2001). "Highly Expressed Genes in Yeast Evolve Slowly". Genetics. 158 (2): 927–931. PMC 1461684. PMID 11430355.
  13. ^ Zhang, Jianzhi; Yang, Jian-Rong (2015). "Determinants of the rate of protein sequence evolution". Nature Reviews Genetics. 16 (7): 409–420. doi:10.1038/nrg3950. PMC 4523088. PMID 26055156.
  14. ^ Koonin, E. V. (2011). "Are there laws of genome evolution?". PLOS Computational Biology. 7 (8): e1002173. arXiv:1108.3589. Bibcode:2011PLSCB...7E2173K. doi:10.1371/journal.pcbi.1002173. PMC 3161903. PMID 21901087.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  15. ^ Papp, Balázs; Pál, Csaba; Hurst, Laurence D. (July 2003). "Dosage sensitivity and the evolution of gene families in yeast". Nature. 424 (6945): 194–197. Bibcode:2003Natur.424..194P. doi:10.1038/nature01771. ISSN 1476-4687. PMID 12853957. Retrieved 10 July 2003.
  16. ^ Birchler, J. A.; Veitia, R. A. (20 August 2012). "Gene balance hypothesis: Connecting issues of dosage sensitivity across biological disciplines". Proceedings of the National Academy of Sciences. 109 (37): 14746–14753. doi:10.1073/pnas.1207726109. ISSN 0027-8424. PMID 22908297. Retrieved Sep 11, 2012.
  17. ^ Pal, Csaba; Maciá, María D.; Oliver, Antonio; Schachar, Ira; Buckling, Angus (December 2007). "Coevolution with viruses drives the evolution of bacterial mutation rates". Nature. 450 (7172): 1079–1081. Bibcode:2007Natur.450.1079P. doi:10.1038/nature06350. ISSN 1476-4687. PMID 18059461. Retrieved 2 December 2007.
  18. ^ Szamecz, Béla; Boross, Gábor; Kalapis, Dorottya; Kovács, Károly; Fekete, Gergely; Farkas, Zoltán; Lázár, Viktória; Hrtyan, Mónika; Kemmeren, Patrick; Groot Koerkamp, Marian J. A.; Rutkai, Edit; Holstege, Frank C. P.; Papp, Balázs; Pál, Csaba (2014). "The Genomic Landscape of Compensatory Evolution". PLOS Biology. 12 (8): e1001935. doi:10.1371/journal.pbio.1001935. PMC 4144845. PMID 25157590.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  19. ^ Szamecz, Béla; Boross, Gábor; Kalapis, Dorottya; Kovács, Károly; Fekete, Gergely; Farkas, Zoltán; Lázár, Viktória; Hrtyan, Mónika; Kemmeren, Patrick; Groot Koerkamp, Marian J. A.; Rutkai, Edit; Holstege, Frank C. P.; Papp, Balázs; Pál, Csaba (2014). "The Genomic Landscape of Compensatory Evolution". PLOS Biology. 12 (8): e1001935. doi:10.1371/journal.pbio.1001935. PMC 4144845. PMID 25157590.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  20. ^ Papp, Balázs; Notebaart, Richard A.; Pál, Csaba (September 2011). "Systems-biology approaches for predicting genomic evolution". Nature Reviews Genetics. 12 (9): 591–602. doi:10.1038/nrg3033. ISSN 1471-0064. PMID 21808261. Retrieved 2 August 2011.
  21. ^ Papp, Balázs; Pál, Csaba; Hurst, Laurence D. (June 2004). "Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast". Nature. 429 (6992): 661–664. Bibcode:2004Natur.429..661P. doi:10.1038/nature02636. ISSN 1476-4687. PMID 15190353. Retrieved 10 June 2004.
  22. ^ Pál, Csaba; Papp, Balázs; Lercher, Martin J. (December 2005). "Adaptive evolution of bacterial metabolic networks by horizontal gene transfer". Nature Genetics. 37 (12): 1372–1375. doi:10.1038/ng1686. ISSN 1546-1718. PMID 16311593. Retrieved 20 November 2005.
  23. ^ Pál, Csaba; Papp, Balázs; Lercher, Martin J.; Csermely, Péter; Oliver, Stephen G.; Hurst, Laurence D. (March 2006). "Chance and necessity in the evolution of minimal metabolic networks". Nature. 440 (7084): 667–670. Bibcode:2006Natur.440..667P. doi:10.1038/nature04568. ISSN 1476-4687. PMID 16572170. Retrieved 30 March 2006.
  24. ^ Harrison, Richard; Papp, Balázs; Pál, Csaba; Oliver, Stephen G.; Delneri, Daniela (13 February 2007). "Plasticity of genetic interactions in metabolic networks of yeast". Proceedings of the National Academy of Sciences. 104 (7): 2307–2312. Bibcode:2007PNAS..104.2307H. doi:10.1073/pnas.0607153104. ISSN 0027-8424. PMID 17284612. Retrieved February 13, 2007.
  25. ^ Szappanos, Balázs; Kovács, Károly; Szamecz, Béla; Honti, Frantisek; Costanzo, Michael; Baryshnikova, Anastasia; Gelius-Dietrich, Gabriel; Lercher, Martin J.; Jelasity, Márk; Myers, Chad L.; Andrews, Brenda J.; Boone, Charles; Oliver, Stephen G.; Pál, Csaba; Papp, Balázs (July 2011). "An integrated approach to characterize genetic interaction networks in yeast metabolism". Nature Genetics. 43 (7): 656–662. doi:10.1038/ng.846. ISSN 1546-1718. PMC 3125439. PMID 21623372.
  26. ^ Notebaart, Richard A.; Szappanos, Balázs; Kintses, Bálint; Pál, Ferenc; Györkei, Ádám; Bogos, Balázs; Lázár, Viktória; Spohn, Réka; Csörgő, Bálint; Wagner, Allon; Ruppin, Eytan; Pál, Csaba; Papp, Balázs (12 August 2014). "Network-level architecture and the evolutionary potential of underground metabolism". Proceedings of the National Academy of Sciences. 111 (32): 11762–11767. Bibcode:2014PNAS..11111762N. doi:10.1073/pnas.1406102111. ISSN 0027-8424. PMID 25071190. Retrieved August 12, 2014.
  27. ^ Szappanos, Balázs; Fritzemeier, Jonathan; Csörgő, Bálint; Lázár, Viktória; Lu, Xiaowen; Fekete, Gergely; Bálint, Balázs; Herczeg, Róbert; Nagy, István; Notebaart, Richard A.; Lercher, Martin J.; Pál, Csaba; Papp, Balázs (20 May 2016). "Adaptive evolution of complex innovations through stepwise metabolic niche expansion". Nature Communications. 7 (1): 11607. Bibcode:2016NatCo...711607S. doi:10.1038/ncomms11607. ISSN 2041-1723. PMID 27197754. Retrieved 20 May 2016.
  28. ^ Lázár, Viktória; Pal Singh, Gajinder; Spohn, Réka; Nagy, István; Horváth, Balázs; Hrtyan, Mónika; Busa‐Fekete, Róbert; Bogos, Balázs; Méhi, Orsolya; Csörgő, Bálint; Pósfai, György; Fekete, Gergely; Szappanos, Balázs; Kégl, Balázs; Papp, Balázs; Pál, Csaba (2013). "Bacterial evolution of antibiotic hypersensitivity". Molecular Systems Biology. 9: 700. doi:10.1038/msb.2013.57. PMC 3817406. PMID 24169403.
  29. ^ Bokor, Dóra (11 June 2018). "Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance". MTA.hu (in Hungarian). Retrieved 11 June 2018.
  30. ^ Pál, Csaba; Papp, Balázs; Pósfai, György (28 May 2014). "The dawn of evolutionary genome engineering". Nature Reviews Genetics. 15 (7): 504–512. doi:10.1038/nrg3746. ISSN 1471-0056. PMID 24866756. Retrieved 28 May 2014.
  31. ^ Nyerges, Ákos; Csörgő, Bálint; Nagy, István; Latinovics, Dóra; Szamecz, Béla; Pósfai, György; Pál, Csaba (1 April 2014). "Conditional DNA repair mutants enable highly precise genome engineering". Nucleic Acids Research. 42 (8): e62. doi:10.1093/nar/gku105. ISSN 0305-1048. PMC 4005651. PMID 24500200.
  32. ^ Nyerges, Ákos; Csörgő, Bálint; Nagy, István; Bálint, Balázs; Bihari, Péter; Lázár, Viktória; Apjok, Gábor; Umenhoffer, Kinga; Bogos, Balázs; Pósfai, György; Pál, Csaba (11 February 2016). "A highly precise and portable genome engineering method allows comparison of mutational effects across bacterial species". Proceedings of the National Academy of Sciences. 113 (9): 2502–2507. Bibcode:2016PNAS..113.2502N. doi:10.1073/pnas.1520040113. ISSN 0027-8424. PMC 4780621. PMID 26884157. Retrieved February 16, 2016.
  33. ^ "Lieben Prize". Wikipedia. 17 January 2020. Retrieved 29 January 2020.
  34. ^ "Csaba Pal". stipendien.oeaw.ac.at. Retrieved 17 November 2008.
  35. ^ "Szent-Györgyi Talents Award". www.nobel-szeged.hu. Retrieved 29 January 2020.
  36. ^ "Pál Csaba biológus a Bolyai-díjas 2015-ben". Hivatalos weboldalra költözött a Bolyai-díj. Retrieved 17 May 2015.
  37. ^ "Bolyai-díj – 2015". National Geographic (in Hungarian). Retrieved 18 May 2015.
  38. ^ "Biologist Csaba Pál is awarded this year's Bolyai Prize". www.t-systems.hu. Retrieved 18 May 2015.
  39. ^ "Pál Csaba biológus kapta az idei Bolyai-díjat". hirado.hu (in Hungarian). Retrieved 17 May 2015.
  40. ^ "Academy of Europe: P%C 3%A 1 l Csaba". www.ae-info.org. Retrieved 28 January 2020.
  41. ^ Jukic, Igor. "EMBO welcomes 65 new members". EMBO. Retrieved 16 June 2017.
  42. ^ "Find people in the EMBO Communities". people.embo.org. Retrieved 28 January 2020.
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