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==Early life and education==
==Early life and education==
Richard H. Ebright was born on 11 June 1959 to Richard Jerome Ebright and Jacqueline Katherine Ebright. His father died when he was in third grade. He grew up north of [[Reading, Pennsylvania|Reading]], [[Pennsylvania]].<ref name=":0">{{Cite book|last=|first=|url=http://ncert.nic.in/textbook/textbook.htm?jefp1=7-10|title=Footprints Without Feet|last2=|first2=|last3=|first3=|last4=|first4=|last5=|first5=|last6=|first6=|first7=|last8=|first8=|last9=|publisher=NCERT|year=|isbn=|location=|pages=32-37|chapter=The Making of a Scientist}}</ref>
Richard H. Ebright was born on 11 June 1959 to Richard J. Ebright and Jacqueline K. Ebright. He grew up north of [[Reading, Pennsylvania|Reading]], [[Pennsylvania]].<ref name=":0">{{Cite book|last=|first=|url=http://ncert.nic.in/textbook/textbook.htm?jefp1=7-10|title=Footprints Without Feet|last2=|first2=|last3=|first3=|last4=|first4=|last5=|first5=|last6=|first6=|first7=|last8=|first8=|last9=|publisher=NCERT|year=|isbn=|location=|pages=32-37|chapter=The Making of a Scientist}}</ref>


Ebright received an [[Bachelor of Arts|A.B.]] ''[[summa cum laude]]'' in biology from [[Harvard University]] in 1981 and a Ph.D. in Microbiology and Molecular Genetics from [[Harvard University]] in 1987. He was a Junior Fellow of the [[Harvard Society of Fellows]] from 1984 to 1987.<ref name=":0" />
Ebright received an [[Bachelor of Arts|A.B.]] ''[[summa cum laude]]'' in biology from [[Harvard University]] in 1981 and a Ph.D. in Microbiology and Molecular Genetics from [[Harvard University]] in 1987. He was a Junior Fellow of the [[Harvard Society of Fellows]] from 1984 to 1987.<ref name=":0" />
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| pmid = 23086998
| pmid = 23086998
| pmc = 3593053| volume=338 | issue=6110 | pages=1076–80
| pmc = 3593053| volume=338 | issue=6110 | pages=1076–80
}}</ref><ref name="Kapanidis">{{cite journal |author1=Kapanidis, A. N. |author2=Margeat, E. |author3=Ho, S. O. |author4=Kortkhonjia, E. |author5=Weiss, S. |author6=Ebright, R. H. |year=2006 |title=Initial transcription by RNA polymerase proceeds through a DNA-scrunching mechanism |journal=Science |volume=314 |pages=1144–1147 |pmid=17110578 |doi=10.1126/science.1131399 |pmc=2754788 }}</ref><ref name="Revyakin">{{cite journal |author1=Revyakin, A. |author2=Liu, C. |author3=Ebright, R. H. |author4=Strick, T. | year = 2006 | title = Abortive initiation and productive initiation by RNA polymerase involve DNA scrunching | url = | journal = Science | volume = 314 | issue = 5802| pages = 1139–1143 | doi = 10.1126/science.1131398 | pmid = 17110577 | pmc = 2754787 | bibcode = 2006Sci...314.1139R }}</ref> [[activator (genetics)|transcription activation]],<ref name="Benoff">{{cite journal |author1=Benoff, B. |author2=Yang, H. |author3=Lawson, C. L. |author4=Parkinson, G. |author5=Liu, J. |author6=Blatter, E. |author7=Ebright, Y. W. |author8=Berman, H. M. |author9=Arnold, E. |author10=Ebright, R. H. |year=2002 |title=Structural basis of transcription activation: the CAP-alphaCTD-DNA complex |journal=Science |volume=297 |issue=5586 |pages=1562–1566 |PMID=12202833 |doi=10.1126/science.1076376 |bibcode=2002Sci...297.1562B }}</ref><ref name="Feng">{{cite journal |author1=Feng, Y. |author2=Zhang, Y. |author3=Ebright, R. H. |year=2016 |title=Structural basis of transcription activation |journal=Science |volume=352 |issue=6291 |pages=1330–1333 |doi=10.1126/science.aaf4417 |pmid= 27284196 |pmc=4905602}}</ref> and [[antibacterial]] drug discovery.<ref name="Mukhopadhyay">{{cite journal |author1=Mukhopadhyay, J. |author2=Das, K. |author3=Ismail, S. |author4=Koppstein, D. |author5=Jang, M. |author6=Hudson, B. |author7=Sarafianos, S. |author8=Tuske, S. |author9=Patel, J. |author10=Jansen, R. |author11=Irschik, H. |author12=Arnold, E. |author13=Ebright, R. H. |lastauthoramp=yes |year=2008 |title=The RNA polymerase "switch region" is a target for inhibitors |journal=Cell |volume=135 |issue=2 |pages=295–307 |doi=10.1016/j.cell.2008.09.033 |pmc=2580802 |pmid=18957204 }}</ref><ref name="GE23077">{{cite journal |author1=Zhang, Y. |author2=Degen, D. |author3=Ho, M. X. |author4=Sineva, E. |author5=Ebright, K. |author6=Ebright, Y. W. |author7=Mekler, V. |author8=Vahedian-Movahed, H. |author9=Feng, Y. |author10=Yin, R. |author11=Tuske, S. |author12=Irschik, H. |author13=Jansen, R. |author14=Maffioli, S. |author15=Donadio, S. |author16=Arnold, E. |author17=Ebright, R. H. | year = 2014 | title = GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides | url = | journal = eLife | volume = 3 | pages = e02450 | doi = 10.7554/eLife.02450 | pmid = 24755292 | pmc = 3994528}}</ref><ref name = "Feng Sal">{{cite journal | last1 = Degen | first1= D. | last2 = Feng | first2 = Y. | last3 = Zhang | first3 = Y. | last4 = Ebright | first4 = K. | last5 = Ebright | first5 = Y. | last6 = Gigliotti | first6 = M. | last7 = Vahedian-Movahed | first7 = H. |last8 = Mandal | first8 = S. | last9 = Talaue | first9 = M. | last10 = Connell | first10 = N. | last11 = Arnold | first11 = E. | last12 = Fenical | first12 = W. | last13 = Ebright | first13 = R. |year = 2014 | title = Transcription inhibition by the depsipeptide antibiotic salinamide A | journal = eLife | volume = 3 | pages = e02451 | doi = 10.7554/eLife.02451 | pmid = 24843001 | pmc = 4029172 }}</ref><ref name="Lin">{{cite journal |author1=Lin, W. |author2=Mandal, S. |author3=Degen, D. |author4=Liu, Y. |author5=Ebright, Y. W. |author6=Li. S. |author7=Feng, Y. |author8=Zhang, Y. |author9=Mandal, S. |author10=Jiang, Y. |author11=Liu, S. |author12=Gigliotti, M. |author13=Talaue, M. |author14=Connell, N. |author15=Das, K. |author16=Arnold, E. |author17=Ebright, R. H. |lastauthoramp=yes |year=2017 |title=Structural basis of Mycobacterium tuberculosis transcription and transcription inhibition |journal=Mol. Cell |volume=66 |pages=169–179 |doi=10.1016/j.molcel.2017.03.001 | pmid = 28392175 | pmc = 5438085 }}</ref><ref name="Maffioli">{{cite journal |author1=Maffioli, S. |author2=Zhang, Y. |author3=Degen, D. |author4=Carzaniga, T. |author5=Del Gatto, G. |author6=Serina, S. |author7=Monciardini, P. |author8=Mazzetti, C. |author9=Guglierame, P. |author10=Candiani, G. |author11=Chiriac, A. I. |author12=Facchetti, G. |author13=Kaltofen, P. |author14=Sahl, H.-G. |author15=Dehò, G. |author16=Donadio, S. |author17=Ebright, R. H. |lastauthoramp=yes |year=2017 |title=Antibacterial nucleoside-analog inhibitor of bacterial RNA polymerase |journal=Cell |volume=169 |issue=7 |pages=1240–1248 |doi=10.1016/j.cell.2017.05.042 |pmid=28622509 |pmc=5542026}}</ref><ref name="Lin2018">{{cite journal |author1=Lin, W. |author2=Das, K. |author3=Degen, D. |author4=Mazumder, A. |author5=Duchi, D. |author6=Wang, D. |author7=Ebright, Y. |author8=Ebright, R.Y. |author9=Sineva, E. |author10=Gigliotti, M. |author11=Srivastava, A. |author12=Mandal, S. |author13=Jiang, Y. |author14=Liu, Y. |author15=Yin, R. |author16=Zhang, Z. |author17=Eng, E. |author18=Thomas, D. |author19=Donadio, S. |author20=Zhang, H. |author21=Zhang, C. |author22=Kapanidis, A. |author23=Ebright, R. H. |lastauthoramp=yes |year=2018 |title=Structural basis of transcription inhibition by fidaxomicin (lipiarmycin A3) |journal=Mol. Cell |volume=70 |issue=1 |pages=60–71 |doi=10.1016/j.molcel.2018.02.026 |pmid=29606590|pmc=6205224 }}</ref> Ebright's research results include the experimental demonstration that amino-acid-base contacts mediate DNA sequence recognition in protein–DNA interaction,<ref name="Ebright"/> the determination of the three-dimensional structural organization of the transcription initiation complex;<ref name="Zhang" /> the demonstration that [[abortive initiation|initial transcription]] involves a "[[DNA scrunching]]" mechanism;<ref name="Kapanidis" /><ref name="Revyakin" /> the demonstration that transcription activation can proceed by a "recruitment" mechanism;<ref name="Benoff" /><ref name="Feng" /> and the identification of novel antibacterial drug targets in bacterial RNA polymerase.<ref name="Mukhopadhyay" /><ref name="GE23077" /><ref name="Feng Sal" /><ref name="Lin" /><ref name="Maffioli" /><ref name="Lin2018" />
}}</ref><ref name="Kapanidis">{{cite journal |author1=Kapanidis, A. N. |author2=Margeat, E. |author3=Ho, S. O. |author4=Kortkhonjia, E. |author5=Weiss, S. |author6=Ebright, R. H. |year=2006 |title=Initial transcription by RNA polymerase proceeds through a DNA-scrunching mechanism |journal=Science |volume=314 |pages=1144–1147 |pmid=17110578 |doi=10.1126/science.1131399 |pmc=2754788 }}</ref><ref name="Revyakin">{{cite journal |author1=Revyakin, A. |author2=Liu, C. |author3=Ebright, R. H. |author4=Strick, T. | year = 2006 | title = Abortive initiation and productive initiation by RNA polymerase involve DNA scrunching | url = | journal = Science | volume = 314 | issue = 5802| pages = 1139–1143 | doi = 10.1126/science.1131398 | pmid = 17110577 | pmc = 2754787 | bibcode = 2006Sci...314.1139R }}</ref> [[activator (genetics)|transcription activation]],<ref name="Benoff">{{cite journal |author1=Benoff, B. |author2=Yang, H. |author3=Lawson, C. L. |author4=Parkinson, G. |author5=Liu, J. |author6=Blatter, E. |author7=Ebright, Y. W. |author8=Berman, H. M. |author9=Arnold, E. |author10=Ebright, R. H. |year=2002 |title=Structural basis of transcription activation: the CAP-alphaCTD-DNA complex |journal=Science |volume=297 |issue=5586 |pages=1562–1566 |PMID=12202833 |doi=10.1126/science.1076376 |bibcode=2002Sci...297.1562B }}</ref><ref name="Feng">{{cite journal |author1=Feng, Y. |author2=Zhang, Y. |author3=Ebright, R. H. |year=2016 |title=Structural basis of transcription activation |journal=Science |volume=352 |issue=6291 |pages=1330–1333 |doi=10.1126/science.aaf4417 |pmid= 27284196 |pmc=4905602}}</ref> transcription-translation coupling,<ref name="Wang">{{cite journal |author1=Wang, C. |author2=Molodtsov, V |author3=Firlar, E.|author4=Kaelber, J. |author5=Blaha, G. |author6=Su, M. |author7=Ebright, R. H. |lastauthoramp=yes |year=2020 |title=Structural basis of transcription-translation coupling |journal=Science |doi=10.1126/science.abb5317 |pmid=32820061 }}</ref> and [[antibacterial]] drug discovery.<ref name="Mukhopadhyay">{{cite journal |author1=Mukhopadhyay, J. |author2=Das, K. |author3=Ismail, S. |author4=Koppstein, D. |author5=Jang, M. |author6=Hudson, B. |author7=Sarafianos, S. |author8=Tuske, S. |author9=Patel, J. |author10=Jansen, R. |author11=Irschik, H. |author12=Arnold, E. |author13=Ebright, R. H. |lastauthoramp=yes |year=2008 |title=The RNA polymerase "switch region" is a target for inhibitors |journal=Cell |volume=135 |issue=2 |pages=295–307 |doi=10.1016/j.cell.2008.09.033 |pmc=2580802 |pmid=18957204 }}</ref><ref name="GE23077">{{cite journal |author1=Zhang, Y. |author2=Degen, D. |author3=Ho, M. X. |author4=Sineva, E. |author5=Ebright, K. |author6=Ebright, Y. W. |author7=Mekler, V. |author8=Vahedian-Movahed, H. |author9=Feng, Y. |author10=Yin, R. |author11=Tuske, S. |author12=Irschik, H. |author13=Jansen, R. |author14=Maffioli, S. |author15=Donadio, S. |author16=Arnold, E. |author17=Ebright, R. H. | year = 2014 | title = GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides | url = | journal = eLife | volume = 3 | pages = e02450 | doi = 10.7554/eLife.02450 | pmid = 24755292 | pmc = 3994528}}</ref><ref name = "Feng Sal">{{cite journal | last1 = Degen | first1= D. | last2 = Feng | first2 = Y. | last3 = Zhang | first3 = Y. | last4 = Ebright | first4 = K. | last5 = Ebright | first5 = Y. | last6 = Gigliotti | first6 = M. | last7 = Vahedian-Movahed | first7 = H. |last8 = Mandal | first8 = S. | last9 = Talaue | first9 = M. | last10 = Connell | first10 = N. | last11 = Arnold | first11 = E. | last12 = Fenical | first12 = W. | last13 = Ebright | first13 = R. |year = 2014 | title = Transcription inhibition by the depsipeptide antibiotic salinamide A | journal = eLife | volume = 3 | pages = e02451 | doi = 10.7554/eLife.02451 | pmid = 24843001 | pmc = 4029172 }}</ref><ref name="Lin">{{cite journal |author1=Lin, W. |author2=Mandal, S. |author3=Degen, D. |author4=Liu, Y. |author5=Ebright, Y. W. |author6=Li. S. |author7=Feng, Y. |author8=Zhang, Y. |author9=Mandal, S. |author10=Jiang, Y. |author11=Liu, S. |author12=Gigliotti, M. |author13=Talaue, M. |author14=Connell, N. |author15=Das, K. |author16=Arnold, E. |author17=Ebright, R. H. |lastauthoramp=yes |year=2017 |title=Structural basis of Mycobacterium tuberculosis transcription and transcription inhibition |journal=Mol. Cell |volume=66 |pages=169–179 |doi=10.1016/j.molcel.2017.03.001 | pmid = 28392175 | pmc = 5438085 }}</ref><ref name="Maffioli">{{cite journal |author1=Maffioli, S. |author2=Zhang, Y. |author3=Degen, D. |author4=Carzaniga, T. |author5=Del Gatto, G. |author6=Serina, S. |author7=Monciardini, P. |author8=Mazzetti, C. |author9=Guglierame, P. |author10=Candiani, G. |author11=Chiriac, A. I. |author12=Facchetti, G. |author13=Kaltofen, P. |author14=Sahl, H.-G. |author15=Dehò, G. |author16=Donadio, S. |author17=Ebright, R. H. |lastauthoramp=yes |year=2017 |title=Antibacterial nucleoside-analog inhibitor of bacterial RNA polymerase |journal=Cell |volume=169 |issue=7 |pages=1240–1248 |doi=10.1016/j.cell.2017.05.042 |pmid=28622509 |pmc=5542026}}</ref><ref name="Lin2018">{{cite journal |author1=Lin, W. |author2=Das, K. |author3=Degen, D. |author4=Mazumder, A. |author5=Duchi, D. |author6=Wang, D. |author7=Ebright, Y. |author8=Ebright, R.Y. |author9=Sineva, E. |author10=Gigliotti, M. |author11=Srivastava, A. |author12=Mandal, S. |author13=Jiang, Y. |author14=Liu, Y. |author15=Yin, R. |author16=Zhang, Z. |author17=Eng, E. |author18=Thomas, D. |author19=Donadio, S. |author20=Zhang, H. |author21=Zhang, C. |author22=Kapanidis, A. |author23=Ebright, R. H. |lastauthoramp=yes |year=2018 |title=Structural basis of transcription inhibition by fidaxomicin (lipiarmycin A3) |journal=Mol. Cell |volume=70 |issue=1 |pages=60–71 |doi=10.1016/j.molcel.2018.02.026 |pmid=29606590|pmc=6205224 }}</ref> Ebright's research results include the experimental demonstration that amino-acid-base contacts mediate DNA sequence recognition in protein–DNA interaction,<ref name="Ebright"/> the determination of the three-dimensional structural organization of the transcription initiation complex;<ref name="Zhang" /> the demonstration that [[abortive initiation|initial transcription]] involves a "[[DNA scrunching]]" mechanism;<ref name="Kapanidis" /><ref name="Revyakin" /> the demonstration that transcription activation can proceed by a "recruitment" mechanism;<ref name="Benoff" /><ref name="Feng" /> the demonstration that bacterial transcription-translation coupling involves direct physical bridging of [[RNA polymerase]] and a [[ribosome]] by NusA and NusG<ref name="Wang" />; and the identification of novel antibacterial drug targets in bacterial RNA polymerase.<ref name="Mukhopadhyay" /><ref name="GE23077" /><ref name="Feng Sal" /><ref name="Lin" /><ref name="Maffioli" /><ref name="Lin2018" />


In 1994 Ebright was awarded the American Society of Biochemistry and Molecular Biology Schering-Plough Award for his research on transcription activation.<ref name="ASBMB">{{cite web |title=ASBMB/Schering-Plough Research Institute Award |url=http://www.asbmb.org/Page.aspx?id=510 |accessdate=October 8, 2011 }}</ref> In 1995 he received the Academic Press Walter J. Johnson Prize.<ref>{{Cite journal
In 1994 Ebright was awarded the American Society of Biochemistry and Molecular Biology Schering-Plough Award for his research on transcription activation.<ref name="ASBMB">{{cite web |title=ASBMB/Schering-Plough Research Institute Award |url=http://www.asbmb.org/Page.aspx?id=510 |accessdate=October 8, 2011 }}</ref> In 1995 he received the Academic Press Walter J. Johnson Prize.<ref>{{Cite journal

Revision as of 19:52, 21 August 2020

Richard H. Ebright
Born (1959-06-11) June 11, 1959 (age 65)
NationalityAmerican
CitizenshipAmerican
Alma mater
Scientific career
FieldsBiology, Molecular Biology
Institutions

Richard H. Ebright is an American molecular biologist. He is the Board of Governors Professor of Chemistry and Chemical Biology at Rutgers University and Laboratory Director at the Waksman Institute of Microbiology.[1][2]

Early life and education

Richard H. Ebright was born on 11 June 1959 to Richard J. Ebright and Jacqueline K. Ebright. He grew up north of Reading, Pennsylvania.[3]

Ebright received an A.B. summa cum laude in biology from Harvard University in 1981 and a Ph.D. in Microbiology and Molecular Genetics from Harvard University in 1987. He was a Junior Fellow of the Harvard Society of Fellows from 1984 to 1987.[3]

Career

Ebright was appointed as a faculty member in the Department of Chemistry at Rutgers University and as a Laboratory Director at the Waksman Institute of Microbiology in 1987. He was co-appointed as an Investigator of the Howard Hughes Medical Institute from 1997 to 2013.

Ebright has performed research on protein-DNA interaction,[4] transcription initiation,[5][6][7] transcription activation,[8][9] transcription-translation coupling,[10] and antibacterial drug discovery.[11][12][13][14][15][16] Ebright's research results include the experimental demonstration that amino-acid-base contacts mediate DNA sequence recognition in protein–DNA interaction,[4] the determination of the three-dimensional structural organization of the transcription initiation complex;[5] the demonstration that initial transcription involves a "DNA scrunching" mechanism;[6][7] the demonstration that transcription activation can proceed by a "recruitment" mechanism;[8][9] the demonstration that bacterial transcription-translation coupling involves direct physical bridging of RNA polymerase and a ribosome by NusA and NusG[10]; and the identification of novel antibacterial drug targets in bacterial RNA polymerase.[11][12][13][14][15][16]

In 1994 Ebright was awarded the American Society of Biochemistry and Molecular Biology Schering-Plough Award for his research on transcription activation.[17] In 1995 he received the Academic Press Walter J. Johnson Prize.[18] In 2013 he received a National Institutes of Health MERIT Award.[19] He was elected as a Fellow of the American Academy of Microbiology in 1996,[20] the American Association for the Advancement of Science in 2004,[21] the Infectious Diseases Society of America in 2011,[22] and the American Academy of Arts and Sciences in 2016.[23]

Ebright has opposed the proliferation of laboratories working on biological weapons agents[24] and has supported the strengthening of biosafety and biosecurity measures to reduce risks of release of biological weapons.[25]

References

  1. ^ "Ebright, Richard H." Department of Chemistry, Rutgers University. Retrieved October 6, 2011.
  2. ^ "Dr. Richard H. Ebright". Waksman Institute, Rutgers University. Retrieved October 6, 2011.
  3. ^ a b "The Making of a Scientist". Footprints Without Feet. NCERT. pp. 32–37.
  4. ^ a b Ebright, R. H.; Cossart, P.; Gicquel-Sanzey, B.; Beckwith, J. (1984). "Mutations that alter the DNA sequence specificity of the catabolite gene activator protein of E. coli". Nature. 311 (5983): 232–235. doi:10.1038/311232a0. PMID 6090927.
  5. ^ a b Zhang, Y.; Feng, Y.; Chatterjee, S.; Tuske, S.; Ho, M. X.; Arnold, E.; Ebright, R. H. (2012). "Structural Basis of Transcription Initiation". Science. 338 (6110): 1076–80. doi:10.1126/science.1227786. PMC 3593053. PMID 23086998.
  6. ^ a b Kapanidis, A. N.; Margeat, E.; Ho, S. O.; Kortkhonjia, E.; Weiss, S.; Ebright, R. H. (2006). "Initial transcription by RNA polymerase proceeds through a DNA-scrunching mechanism". Science. 314: 1144–1147. doi:10.1126/science.1131399. PMC 2754788. PMID 17110578.
  7. ^ a b Revyakin, A.; Liu, C.; Ebright, R. H.; Strick, T. (2006). "Abortive initiation and productive initiation by RNA polymerase involve DNA scrunching". Science. 314 (5802): 1139–1143. Bibcode:2006Sci...314.1139R. doi:10.1126/science.1131398. PMC 2754787. PMID 17110577.
  8. ^ a b Benoff, B.; Yang, H.; Lawson, C. L.; Parkinson, G.; Liu, J.; Blatter, E.; Ebright, Y. W.; Berman, H. M.; Arnold, E.; Ebright, R. H. (2002). "Structural basis of transcription activation: the CAP-alphaCTD-DNA complex". Science. 297 (5586): 1562–1566. Bibcode:2002Sci...297.1562B. doi:10.1126/science.1076376. PMID 12202833.
  9. ^ a b Feng, Y.; Zhang, Y.; Ebright, R. H. (2016). "Structural basis of transcription activation". Science. 352 (6291): 1330–1333. doi:10.1126/science.aaf4417. PMC 4905602. PMID 27284196.
  10. ^ a b Wang, C.; Molodtsov, V; Firlar, E.; Kaelber, J.; Blaha, G.; Su, M.; Ebright, R. H. (2020). "Structural basis of transcription-translation coupling". Science. doi:10.1126/science.abb5317. PMID 32820061. {{cite journal}}: Unknown parameter |lastauthoramp= ignored (|name-list-style= suggested) (help)
  11. ^ a b Mukhopadhyay, J.; Das, K.; Ismail, S.; Koppstein, D.; Jang, M.; Hudson, B.; Sarafianos, S.; Tuske, S.; Patel, J.; Jansen, R.; Irschik, H.; Arnold, E.; Ebright, R. H. (2008). "The RNA polymerase "switch region" is a target for inhibitors". Cell. 135 (2): 295–307. doi:10.1016/j.cell.2008.09.033. PMC 2580802. PMID 18957204. {{cite journal}}: Unknown parameter |lastauthoramp= ignored (|name-list-style= suggested) (help)
  12. ^ a b Zhang, Y.; Degen, D.; Ho, M. X.; Sineva, E.; Ebright, K.; Ebright, Y. W.; Mekler, V.; Vahedian-Movahed, H.; Feng, Y.; Yin, R.; Tuske, S.; Irschik, H.; Jansen, R.; Maffioli, S.; Donadio, S.; Arnold, E.; Ebright, R. H. (2014). "GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides". eLife. 3: e02450. doi:10.7554/eLife.02450. PMC 3994528. PMID 24755292.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  13. ^ a b Degen, D.; Feng, Y.; Zhang, Y.; Ebright, K.; Ebright, Y.; Gigliotti, M.; Vahedian-Movahed, H.; Mandal, S.; Talaue, M.; Connell, N.; Arnold, E.; Fenical, W.; Ebright, R. (2014). "Transcription inhibition by the depsipeptide antibiotic salinamide A". eLife. 3: e02451. doi:10.7554/eLife.02451. PMC 4029172. PMID 24843001.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  14. ^ a b Lin, W.; Mandal, S.; Degen, D.; Liu, Y.; Ebright, Y. W.; Li. S.; Feng, Y.; Zhang, Y.; Mandal, S.; Jiang, Y.; Liu, S.; Gigliotti, M.; Talaue, M.; Connell, N.; Das, K.; Arnold, E.; Ebright, R. H. (2017). "Structural basis of Mycobacterium tuberculosis transcription and transcription inhibition". Mol. Cell. 66: 169–179. doi:10.1016/j.molcel.2017.03.001. PMC 5438085. PMID 28392175. {{cite journal}}: Unknown parameter |lastauthoramp= ignored (|name-list-style= suggested) (help)
  15. ^ a b Maffioli, S.; Zhang, Y.; Degen, D.; Carzaniga, T.; Del Gatto, G.; Serina, S.; Monciardini, P.; Mazzetti, C.; Guglierame, P.; Candiani, G.; Chiriac, A. I.; Facchetti, G.; Kaltofen, P.; Sahl, H.-G.; Dehò, G.; Donadio, S.; Ebright, R. H. (2017). "Antibacterial nucleoside-analog inhibitor of bacterial RNA polymerase". Cell. 169 (7): 1240–1248. doi:10.1016/j.cell.2017.05.042. PMC 5542026. PMID 28622509. {{cite journal}}: Unknown parameter |lastauthoramp= ignored (|name-list-style= suggested) (help)
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