Talk:Antiphospholipid syndrome

Rename article

The suggestion is made in this article that the anti phospholipid syndrome is caused by auto antibodies directed against negatively charged phospholipids on the cell/platelet surface. However for almost 15 years it is known that most of the antibodies in this syndrome are directed against proteins that bind negatively charged phospholipids such as prothrombin and beta-2-glycoprotein-1. It is the binding of antibodies to coagulation proteins that causes altered coagulation processes not the binding of antibodies against negatively charged phospholipids.

I suggest to change the article to correct this misunderstanding. Bio2mancer 24 june 2006.

{{sofixit}} JFW | T@lk 20:58, 4 July 2006 (UTC)

Sapporo criteria

We should mention the Sapporo criteria: PMID 10403256 . JFW | T@lk 20:58, 4 July 2006 (UTC)

And a recent amendment: PMID 16420554 . JFW | T@lk 20:59, 4 July 2006 (UTC)

Recent review

A recent systematic review on the treatment shows how little we actually know about optimal treatment for this: PMID 16507806. JFW | T@lk 21:01, 4 July 2006 (UTC)

Furthermore, a new study in the New England Journal of Medicine -- Kaandorp SP et al, N Engl J Med 362;17p1586–1596 shows no benefit of aspirin + LMWH over placebo -- in women with recurrent miscarriage -- and the accompanying editorial states that although inherited thrombophilia is associated with miscarriage, anticoagulants in this indication don't help. We know less than we think!

Page has massive changes

Since 07 NOV 06...actually making this page very inaccurate. Please revert back to previous revision before 07 NOV 06. Tried to get the categories back in. Hopefully I did it right.eyz 00:10, 21 November 2006 (UTC)

Typo

Changed a typo (phosphotidylserine to Phosphatidylserine). Rage italic 15:54, 30 March 2007 (UTC)

APSFA Page

Actaully that page is cited and is HONCode certifed. Very few sites can say that. It has a bio. upon request.eyz 17:53, 20 May 2007 (UTC)

APSCORE

APSCORE is no longer functioning due to lack of funding from the CDC and NIH. Link Removed. eyz

Nature of antibodies

Some antibodies are more aborto/thrombogenic than others PMID 17440049 JFW | T@lk 06:42, 7 August 2007 (UTC)

Blood!

doi:10.1182/blood-2007-12-129627 - how we diagnose APS. JFW | T@lk 17:29, 1 February 2009 (UTC)

Source

Is House MD a reliable and authentic source? — Preceding unsigned comment added by 93.208.112.205 (talk) 20:15, 21 September 2011 (UTC)

Absolutely not. House MD is entertainment, not a reliable source for anything.Wzrd1 (talk) 17:53, 3 February 2012 (UTC)

Review

doi:10.1182/blood-2012-03-378646 the relevance of anti-β2-glycoprotein I antibodies. JFW | T@lk 20:57, 12 July 2012 (UTC)

NEJM mechanisms of disease: doi:10.1056/NEJMra1112830 JFW | T@lk 16:09, 14 March 2013 (UTC)

Historical review in Br J Haem doi:10.1111/bjh.12848 JFW | T@lk 18:59, 31 March 2014 (UTC)

Laboratory technique

doi:10.1111/jth.12537 ISTH JFW | T@lk 07:17, 25 May 2014 (UTC)

Sentence

Hi. In the section under the subsubhead 2.1, Lupus anticoagulant, we currently begin the second paragraph thus: "Distinguishing a lupus antibody from a specific coagulation factor inhibitor (eg: Factor VIII)." This is not a sentence and does not make sense on its own. I'd fix it if I was sure how to without distorting the intended sense, but I'm not. (I was tempted to weld it into the next sentence but I'm not 100% certain that works - or was it like a yet another subhead perhaps??) Can someone who can see the sense of the whole thing please sort it out? Thanks and best wishes, DBaK (talk) 11:21, 20 November 2009 (UTC)

Fixed, though it's likely the whole section (and many others) should be drastically cut back; encyclopedias don't normally, and shouldn't, give specific diagnostic criteria and protocols - especially when these vary from place to place. Grothmag (talk) 00:13, 9 February 2016 (UTC)

Request to create disambiguation(s)

I only recently heard of this disease, and had quite a bit of difficulty finding information about it until someone mentioned that it was called by names, including “APLS or APLA in the United States and Hughes Syndrome or Sticky Blood in the UK” (information taken from the APS Foundation of America). Given the disparity of naming for the condition, I would think it appropriate to include it on various disambiguation pages and/or redirects, as appropriate, to make this information easier to locate.

I’m not familiar enough with Wikipedia’s policies to be comfortable introducing such changes myself, but I welcome others to consider those additions. Much thanks!

jF 11:48, 3 June 2016 (UTC) — Preceding unsigned comment added by 2601:3CA:204:F860:D824:EC9F:804C:D3BF (talk)

New review

doi:10.1111/bjh.14632 JFW | T@lk 19:55, 26 March 2017 (UTC)

ISTH criteria for laboratory diagnosis: doi:10.1111/jth.13976 JFW | T@lk 21:21, 17 February 2018 (UTC)

Something about the DOACs for thromboprophylaxis. doi:10.1111/jth.14017 JFW | T@lk 21:23, 12 April 2018 (UTC)

NEJM this week doi:10.1056/NEJMra1705454 JFW | T@lk 11:33, 24 May 2018 (UTC)

"New bloody syndrome" listed at Redirects for discussion

A discussion is taking place to address the redirect New bloody syndrome. The discussion will occur at Wikipedia:Redirects for discussion/Log/2020 August 2#New bloody syndrome until a consensus is reached, and readers of this page are welcome to contribute to the discussion. Steel1943 (talk) 20:40, 2 August 2020 (UTC)

ISTH SSC

Recommendations about DOACs doi:10.1111/jth.14935 JFW | T@lk 14:20, 1 September 2020 (UTC)