Cerebral salt-wasting syndrome: Difference between revisions
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{{Infobox medical condition (new) |
{{Infobox medical condition (new) |
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| name = Cerebral salt-wasting syndrome |
| name = Cerebral salt-wasting syndrome |
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| field = endocrinology |
| field = endocrinology |
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| synonyms = CSWS |
| synonyms = CSWS |
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'''Cerebral salt-wasting syndrome''' ('''CSWS''') is a [[rare disease|rare]] [[Endocrine disorder|endocrine condition]] featuring a [[hyponatremia|low blood sodium concentration]] and [[dehydration]] in response to injury (trauma) or the presence of tumors in or surrounding the [[brain]]. In this condition, the kidney is functioning normally but excreting excessive sodium.<ref name="Yee2010">{{cite journal |vauthors=Yee AH, Burns JD, Wijdicks EF|title=Cerebral salt wasting: pathophysiology, diagnosis, and treatment|journal=Neurosurg Clin N Am|volume=21 |issue=2 |pages=339–52|date=April 2010|pmid=20380974|doi=10.1016/j.nec.2009.10.011}}</ref> The condition was initially described in 1950.<ref>{{cite journal |vauthors=Peters JP, Welt LG, Sims EA, Orloff J, Needham J |title=A salt-wasting syndrome associated with cerebral disease |journal=Trans. Assoc. Am. Physicians |volume=63 |issue= |pages=57–64 |year=1950 |pmid=14855556}}</ref> Its cause and management remain controversial.<ref name=csws_nejm>{{cite journal |author=Petzold A |title=Disorders of plasma sodium |journal=N Engl J Med |volume=372 |issue=13 |pages=1267–1269 |year=2015 |pmid=25806925 |doi=10.1056/nejmc1501342}}</ref><ref>{{cite journal |author=Sterns RH |title=Disorders of plasma sodium |journal=N Engl J Med |volume=372 |issue=13 |pages=1267–1269 |year=2015 |pmid=25806924 |doi=10.1056/NEJMc1501342}}</ref> |
'''Cerebral salt-wasting syndrome''' ('''CSWS''') is a [[rare disease|rare]] [[Endocrine disorder|endocrine condition]] featuring a [[hyponatremia|low blood sodium concentration]] and [[dehydration]] in response to injury (trauma) or the presence of tumors in or surrounding the [[brain]]. In this condition, the kidney is functioning normally but excreting excessive sodium.<ref name="Yee2010">{{cite journal |vauthors=Yee AH, Burns JD, Wijdicks EF|title=Cerebral salt wasting: pathophysiology, diagnosis, and treatment|journal=Neurosurg Clin N Am|volume=21 |issue=2 |pages=339–52|date=April 2010|pmid=20380974|doi=10.1016/j.nec.2009.10.011}}</ref> The condition was initially described in 1950.<ref>{{cite journal |vauthors=Peters JP, Welt LG, Sims EA, Orloff J, Needham J |title=A salt-wasting syndrome associated with cerebral disease |journal=Trans. Assoc. Am. Physicians |volume=63 |issue= |pages=57–64 |year=1950 |pmid=14855556}}</ref> Its cause and management remain controversial.<ref name=csws_nejm>{{cite journal |author=Petzold A |title=Disorders of plasma sodium |journal=N Engl J Med |volume=372 |issue=13 |pages=1267–1269 |year=2015 |pmid=25806925 |doi=10.1056/nejmc1501342}}</ref><ref>{{cite journal |author=Sterns RH |title=Disorders of plasma sodium |journal=N Engl J Med |volume=372 |issue=13 |pages=1267–1269 |year=2015 |pmid=25806924 |doi=10.1056/NEJMc1501342}}</ref> |
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Signs and symptoms of CSWS include [[polyuria|large amounts of urination]] (polyuria, defined as over three liters of urine output over 24 hours in an adult), high amounts of sodium in the urine, low blood sodium concentration,<ref name="Yee2010"/> [[polydipsia|excessive thirst]] (polydipsia), extreme [[salt]] cravings, [[dysautonomia|dysfunction of the autonomic nervous system]] (dysautonomia), and [[dehydration]]. Patients often self-medicate by consuming high amounts of sodium and by dramatically increasing their water intake. Advanced symptoms include [[muscle cramps]], lightheadedness, dizziness or [[Vertigo (medical)|vertigo]], feelings of anxiety or panic, [[tachycardia|increased heart rate]] or [[bradycardia|slowed heart rate]], [[hypotension|low blood pressure]] and [[orthostatic hypotension]] which can result in [[syncope (medicine)|fainting]].<ref name="isbn0-07-147247-9"/> Other symptoms frequently associated with dysautonomia include [[headaches]], [[pallor]], [[malaise]], facial flushing, [[constipation]] or [[diarrhea]], [[nausea]], [[acid reflux]], visual disturbances, numbness, [[nerve]] pain, [[Shortness of breath|trouble breathing]], chest pain, loss of consciousness, and [[seizures]].<ref name="isbn0-07-147247-9">{{cite book |author=Tierney, Lawrence M. |author2=McPhee, Stephen J. |author3=Papadakis, Maxine A. |title=Current Medical Diagnosis and Treatment 2007 (Current Medical Diagnosis and Treatment) |publisher=McGraw-Hill Professional |location= |year=2006 |pages=1010 |isbn=978-0-07-147247-0 |oclc= |doi= |accessdate=}}</ref> |
Signs and symptoms of CSWS include [[polyuria|large amounts of urination]] (polyuria, defined as over three liters of urine output over 24 hours in an adult), high amounts of sodium in the urine, low blood sodium concentration,<ref name="Yee2010"/> [[polydipsia|excessive thirst]] (polydipsia), extreme [[salt]] cravings, [[dysautonomia|dysfunction of the autonomic nervous system]] (dysautonomia), and [[dehydration]]. Patients often self-medicate by consuming high amounts of sodium and by dramatically increasing their water intake. Advanced symptoms include [[muscle cramps]], lightheadedness, dizziness or [[Vertigo (medical)|vertigo]], feelings of anxiety or panic, [[tachycardia|increased heart rate]] or [[bradycardia|slowed heart rate]], [[hypotension|low blood pressure]] and [[orthostatic hypotension]] which can result in [[syncope (medicine)|fainting]].<ref name="isbn0-07-147247-9"/> Other symptoms frequently associated with dysautonomia include [[headaches]], [[pallor]], [[malaise]], facial flushing, [[constipation]] or [[diarrhea]], [[nausea]], [[acid reflux]], visual disturbances, numbness, [[nerve]] pain, [[Shortness of breath|trouble breathing]], chest pain, loss of consciousness, and [[seizures]].<ref name="isbn0-07-147247-9">{{cite book |author=Tierney, Lawrence M. |author2=McPhee, Stephen J. |author3=Papadakis, Maxine A. |title=Current Medical Diagnosis and Treatment 2007 (Current Medical Diagnosis and Treatment) |publisher=McGraw-Hill Professional |location= |year=2006 |pages=1010 |isbn=978-0-07-147247-0 |oclc= |doi= |accessdate=}}</ref> |
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==Causes |
==Causes== |
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CSWS is usually caused by brain injury/trauma or cerebral lesion, tumor, or hematoma.{{citation needed|date=August 2020}} |
CSWS is usually caused by brain injury/trauma or cerebral lesion, tumor, or hematoma.{{citation needed|date=August 2020}} |
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== External links == |
== External links == |
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{{Medical resources |
{{Medical resources |
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| DiseasesDB = 32234 |
| DiseasesDB = 32234 |
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| ICD10 = |
| ICD10 = |
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| ICD9 = |
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| OMIM = |
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| MedlinePlus = |
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| eMedicineSubj = ped |
| eMedicineSubj = ped |
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| eMedicineTopic = 354 |
| eMedicineTopic = 354 |
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{{Electrolyte abnormalities}} |
{{Electrolyte abnormalities}} |
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Revision as of 14:45, 26 November 2020
| Cerebral salt-wasting syndrome | |
|---|---|
| Other names | CSWS |
| Specialty | Endocrinology |
Cerebral salt-wasting syndrome (CSWS) is a rare endocrine condition featuring a low blood sodium concentration and dehydration in response to injury (trauma) or the presence of tumors in or surrounding the brain. In this condition, the kidney is functioning normally but excreting excessive sodium.[1] The condition was initially described in 1950.[2] Its cause and management remain controversial.[3][4]
Signs and symptoms
Signs and symptoms of CSWS include large amounts of urination (polyuria, defined as over three liters of urine output over 24 hours in an adult), high amounts of sodium in the urine, low blood sodium concentration,[1] excessive thirst (polydipsia), extreme salt cravings, dysfunction of the autonomic nervous system (dysautonomia), and dehydration. Patients often self-medicate by consuming high amounts of sodium and by dramatically increasing their water intake. Advanced symptoms include muscle cramps, lightheadedness, dizziness or vertigo, feelings of anxiety or panic, increased heart rate or slowed heart rate, low blood pressure and orthostatic hypotension which can result in fainting.[5] Other symptoms frequently associated with dysautonomia include headaches, pallor, malaise, facial flushing, constipation or diarrhea, nausea, acid reflux, visual disturbances, numbness, nerve pain, trouble breathing, chest pain, loss of consciousness, and seizures.[5]
Causes
CSWS is usually caused by brain injury/trauma or cerebral lesion, tumor, or hematoma.[citation needed]
Diagnosis
CSWS is a diagnosis of exclusion and may be difficult to distinguish from the syndrome of inappropriate antidiuretic hormone (SIADH), which develops under similar circumstances and also presents with hyponatremia.[1] The main clinical difference is that of total fluid status of the patient: CSWS leads to a relative or overt low blood volume[3] whereas SIADH is consistent with a normal or high blood volume (due to water reabsorption via the V2 receptor).[1] If blood-sodium levels increase when fluids are restricted, SIADH is more likely.[6] Additionally, urine output is classically low in SIADH and elevated in CSWS.[1]
Treatment
While CSWS usually appears within the first week after brain injury and spontaneously resolves in 2–4 weeks, it can sometimes last for months or years. In contrast to the use of fluid restriction to treat SIADH, CSWS is treated by replacing the urinary losses of water and sodium with hydration and sodium replacement.[1] The mineralocorticoid medication fludrocortisone can also improve the low sodium level.[1][7]
References
- ^ a b c d e f g Yee AH, Burns JD, Wijdicks EF (April 2010). "Cerebral salt wasting: pathophysiology, diagnosis, and treatment". Neurosurg Clin N Am. 21 (2): 339–52. doi:10.1016/j.nec.2009.10.011. PMID 20380974.
- ^ Peters JP, Welt LG, Sims EA, Orloff J, Needham J (1950). "A salt-wasting syndrome associated with cerebral disease". Trans. Assoc. Am. Physicians. 63: 57–64. PMID 14855556.
- ^ a b Petzold A (2015). "Disorders of plasma sodium". N Engl J Med. 372 (13): 1267–1269. doi:10.1056/nejmc1501342. PMID 25806925.
- ^ Sterns RH (2015). "Disorders of plasma sodium". N Engl J Med. 372 (13): 1267–1269. doi:10.1056/NEJMc1501342. PMID 25806924.
- ^ a b Tierney, Lawrence M.; McPhee, Stephen J.; Papadakis, Maxine A. (2006). Current Medical Diagnosis and Treatment 2007 (Current Medical Diagnosis and Treatment). McGraw-Hill Professional. p. 1010. ISBN 978-0-07-147247-0.
- ^ Harrigan MR (1996). "Cerebral salt wasting syndrome: a review". Neurosurgery. 38 (1): 152–60. doi:10.1097/00006123-199601000-00035. PMID 8747964.
- ^ Betjes MG (2002). "Hyponatremia in acute brain disease: the cerebral salt wasting syndrome". Eur J Intern Med. 13 (1): 9–14. doi:10.1016/S0953-6205(01)00192-3. PMID 11836078.