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From 2008 to 2013, Heeren was the research director for emerging technologies at the Netherlands Proteomics Centre. In 2012, he co-founded Omics2Image B.V., a company focused on bringing innovative ion detector technology to the analytical market. In 2014, he was appointed to his current position as one of the scientific directors of M4I at Maastricht University.
From 2008 to 2013, Heeren was the research director for emerging technologies at the Netherlands Proteomics Centre. In 2012, he co-founded Omics2Image B.V., a company focused on bringing innovative ion detector technology to the analytical market. In 2014, he was appointed to his current position as one of the scientific directors of M4I at Maastricht University.


Heeren is an active member in numerous professional societies related to his field, including Dutch Physics Society (1993), The American Chemical Society (2010), [https://www.asms.org/ The American Society for Mass Spectrometry] (1994). Heeren was president of the [https://www.nvms.nl/ Dutch Society of Mass Spectrometry] between 2001–2005<ref>{{Cite web|title=History|url=https://www.nvms.nl/index.php/historie/|access-date=2020-12-18|website=NVMS|language=en-US}}</ref>. He is one of the founding members of the Mass Spectrometry Imaging Society, and was elected its president in 2017. (Placeholder1) For his “contributions to the mass spectrometry internationally” (Placeholder4) over his 30-year career, Heeren was awarded the Thomson Medal by the International Mass Spectrometry Society.
Heeren is an active member in numerous professional societies related to his field, including Dutch Physics Society (1993), The American Chemical Society (2010), [https://www.asms.org/ The American Society for Mass Spectrometry] (1994). Heeren was president of the [https://www.nvms.nl/ Dutch Society of Mass Spectrometry] between 2001–2005<ref>{{Cite web|title=History|url=https://www.nvms.nl/index.php/historie/|access-date=2020-12-18|website=NVMS|language=en-US}}</ref>. He is one of the founding members of the [https://ms-imaging.org/wp/mass-spectrometry-imaging-society/ Mass Spectrometry Imaging Society], and was elected its president in 2017. For his “contributions to the mass spectrometry internationally” over his 30-year career, Heeren was awarded the Thomson Medal by the [[International Mass Spectrometry Society]].<ref>{{Cite web|last=Maastricht|first=Minderbroedersberg 4-6 6211 LK|title=Thomson Medal 2020 awarded to Ron Heeren|url=https://www.maastrichtuniversity.nl/news/thomson-medal-2020-awarded-ron-heeren|access-date=2020-12-18|website=www.maastrichtuniversity.nl|language=en}}</ref>


Heeren has coauthored over 300 peer-reviewed articles, which have been cited over 12,600 times (Google Scholar; h index = 58).<ref>{{Cite web|title=Ron M.A. Heeren|url=https://scholar.google.nl/citations?user=PL9UftUAAAAJ&hl=nl|access-date=2020-12-18|website=scholar.google.nl}}</ref>


== Valorization ==
Heeren has translated his innovations and scientific findings to patented techniques and instruments throughout his career. To date, he holds 7 patents (Placeholder5) and has established two spin-off companies, [https://www.amscins.com/ Omics2Image/ASI] and the [https://www.hairdiagnostix.nl/ Dutch Screening Group]. In 2019, Heeren was awarded the NWO Valorisation Prize in Physics<ref>{{Cite web|title=NWO Physics Valorisation Prize 2019 - Ron Heeren - YouTube|url=https://www.youtube.com/watch?v=fCa7VtLT2r4|access-date=2020-12-18|website=www.youtube.com}}</ref> in recognition of his career-long efforts to “researcher [who] has managed to turn the results of their own research into something useful for society."<ref>{{Cite web|title=NWO Physics Valorisation Prize goes to Ron Heeren from Maastricht University {{!}} NWO|url=https://www.nwo.nl/en/news/nwo-physics-valorisation-prize-goes-ron-heeren-maastricht-university|access-date=2020-12-18|website=www.nwo.nl|language=en}}</ref>


== Research ==
Heeren’s academic research interests are the fundamental studies of the energetics of macromolecular systems, conformational studies of non-covalently bound protein complexes, translational imaging research, high-throughput bioinformatics, and the development and validation of new mass spectrometry–based proteomic imaging techniques for the life sciences.


During his postdoctoral fellowship, he worked on the development of innovative ion sources, vacuums systems, data acquisition systems and novel temperature-controlled ion cyclotron resonance cells. He used the FTICR-MS instrument for the study of collisional energy transfer and internal energy distributions.<ref>{{Cite journal|last=Heeren|first=Ron M. A.|last2=Vékey|first2=Károly|date=1998-09-15|title=A novel method to determine collisional energy transfer efficiency by Fourier transform ion cyclotron resonance mass spectrometry|url=http://dx.doi.org/10.1002/(sici)1097-0231(19980915)12:17<1175::aid-rcm305>3.0.co;2-l|journal=Rapid Communications in Mass Spectrometry|volume=12|issue=17|pages=1175–1181|doi=10.1002/(sici)1097-0231(19980915)12:17<1175::aid-rcm305>3.0.co;2-l|issn=0951-4198}}</ref><ref>{{Cite journal|last=Drahos|first=null|last2=Heeren|first2=null|last3=Collette|first3=null|last4=De Pauw E|first4=null|last5=Vekey|first5=null|date=1999-12|title=Thermal energy distribution observed in electrospray ionization|url=https://pubmed.ncbi.nlm.nih.gov/10587635/|journal=Journal of mass spectrometry: JMS|volume=34|issue=12|pages=1373–1379|doi=10.1002/(SICI)1096-9888(199912)34:123.0.CO;2-#|issn=1096-9888|pmid=10587635}}</ref><ref>{{Cite journal|last=Guo|first=Xinghua|last2=Duursma|first2=Marc C.|last3=Kistemaker|first3=Piet G.|last4=Nibbering|first4=Nico M. M.|last5=Vekey|first5=Karoly|last6=Drahos|first6=Laszlo|last7=Heeren|first7=Ron M. A.|date=2003-06|title=Manipulating internal energy of protonated biomolecules in electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry|url=https://pubmed.ncbi.nlm.nih.gov/12827629/|journal=Journal of mass spectrometry: JMS|volume=38|issue=6|pages=597–606|doi=10.1002/jms.480|issn=1076-5174|pmid=12827629}}</ref> These methods were deployed to investigate their role in the determination of dissociation pathways of biomolecular systems.<ref>{{Cite journal|last=Koster|first=Sander|last2=Duursma|first2=Marc C.|last3=Boon|first3=Jaap J.|last4=Nielen|first4=Michel W. F.|last5=de Koster|first5=Chris G.|last6=Heeren|first6=Ron M. A.|date=2000|title=Structural analysis of synthetic homo- and copolyesters by electrospray ionization on a Fourier transform ion cyclotron resonance mass spectrometer|url=http://dx.doi.org/10.1002/1096-9888(200006)35:6<739::aid-jms3>3.0.co;2-#|journal=Journal of Mass Spectrometry|volume=35|issue=6|pages=739–748|doi=10.1002/1096-9888(200006)35:6<739::aid-jms3>3.0.co;2-#|issn=1076-5174}}</ref><ref>{{Cite journal|last=Kleinnijenhuis|first=Anne J.|last2=Duursma|first2=Marc C.|last3=Breukink|first3=Eefjan|last4=Heeren|first4=Ron M. A.|last5=Heck|first5=Albert J. R.|date=2003-07-01|title=Localization of intramolecular monosulfide bridges in lantibiotics determined with electron capture induced dissociation|url=https://pubmed.ncbi.nlm.nih.gov/12964772/|journal=Analytical Chemistry|volume=75|issue=13|pages=3219–3225|doi=10.1021/ac0263770|issn=0003-2700|pmid=12964772}}</ref>


As a project leader (1995–1997), Heeren led the application of high-resolution MS (FTICR-MS, FTIR imaging spectroscopy and SIMS) to the field of conservation science. He discovered and identified saponified pigment particulates in so-called protrusions in Rembrandt’s “[[The Anatomy Lesson of Dr. Nicolaes Tulp]]” in collaboration with the [[Mauritshuis]] museum in The Hague.<ref>{{Cite journal|last=Heeren|first=Ron M. A.|last2=Boon|first2=Jaap J.|last3=Noble|first3=Petria|last4=Wadum|first4=Jørgen|date=1999|title=Integrating imaging FTIR and secondary ion mass spectrometry for the analysis of embedded paint cross-sections|url=https://pure.kb.dk/en/publications/integrating-imaging-ftir-and-secondary-ion-mass-spectrometry-for-|journal=ICOM-CC Triennial meeting (12th), Lyon, 29 August-3 September 1999: preprints.|language=English|pages=228–233}}</ref><ref>{{Citation|title=Recitative after Rembrandt’s “The Anatomy Lesson of Dr. Nicolaes Tulp”|date=2005-03-23|url=http://dx.doi.org/10.2307/j.ctvthhc5r.38|work=90 Miles|pages=78–79|publisher=University of Pittsburgh Press|isbn=978-0-8229-8033-9|access-date=2020-12-18}}</ref><ref>{{Cite journal|last=Van Der Weerd|first=J.|last2=Brammer|first2=H.|last3=Boon|first3=J. J.|last4=Heeren|first4=R. M. A.|date=2002-03|title=Fourier Transform Infrared Microscopic Imaging of an Embedded Paint Cross-Section|url=http://dx.doi.org/10.1366/0003702021954683|journal=Applied Spectroscopy|volume=56|issue=3|pages=275–283|doi=10.1366/0003702021954683|issn=0003-7028}}</ref>

Heeren and his group have pioneered the development of active pixelated detectors for mass spectrometry imaging. One such detector, the [[Medipix]] detector has been adapted to enable microscope-mode imaging mass spectrometry<ref>{{Cite journal|last=Jungmann|first=Julia H.|last2=MacAleese|first2=Luke|last3=Visser|first3=Jan|last4=Vrakking|first4=Marc J. J.|last5=Heeren|first5=Ron M. A.|date=2011-10-15|title=High Dynamic Range Bio-Molecular Ion Microscopy with the Timepix Detector|url=http://dx.doi.org/10.1021/ac2017629|journal=Analytical Chemistry|volume=83|issue=20|pages=7888–7894|doi=10.1021/ac2017629|issn=0003-2700}}</ref> for biomolecules to enable combined high-throughput and high-resolution molecular imaging using [[Matrix-assisted laser desorption/ionization|MALDI]] and [[Secondary ion mass spectrometry|SIMS]].

== Education ==
Prof. Heeren is only one of four distinguished professors at UM.<ref>{{Cite web|title=Distinguished university professors - Research - Maastricht University|url=https://www.maastrichtuniversity.nl/research/distinguished-university-professors|access-date=2020-12-18|website=www.maastrichtuniversity.nl}}</ref> He has supervised more than 60 PhD students and postdoctoral fellows, many of whom have received prestigious awards ([https://www.nwo.nl/en/calls/talent-programme NWO-Vidi] and [https://erc.europa.eu/ ERC grants], for example). Currently, he supervises masters and PhD students at UM, Vrije Universiteit Amsterdam, and the University of Amsterdam.

He delivered a tutorial lecture on Imaging MS at the 2014 annual ASMS conference<ref>{{Citation|last=ASMS|title=Imaging MS: 2014 Tutorial, Ron M.A. Heeren|date=2014-09-06|url=https://vimeo.com/105423855|access-date=2020-12-18}}</ref> and a TEDx Maastricht talk<ref>{{Cite web|title=The New Dawn of Cancer Surgery {{!}} Ron Heeren {{!}} TEDxMaastricht - YouTube|url=https://www.youtube.com/watch?v=tHdvxB23U4Y|access-date=2020-12-18|website=www.youtube.com}}</ref>.

Prof. Heeren is part of the organizing committee of the annual [http://msbm.org/ Mass Spectrometry School in Biotechnology and Medicine summer school] in Dubrovnik. He has designed and established a molecular imaging track in the Biomedical Sciences Master programme and is coordinating the establishment of a new Molecular Imaging and Engineering Master program at UM.

== Awards ==
2020     Hans Fisher Senior Fellowship, Institute of Advanced Studies, Technical University of Munich Hans Fisher senior fellowship<ref>{{Cite web|title=Heeren, Ron M.A. - Institute for Advanced Study (IAS)|url=https://www.ias.tum.de/active-fellows/heeren-ron-ma/|access-date=2020-12-18|website=www.ias.tum.de|language=de}}</ref>

2020     Thomson medal, International Mass Spectrometry Foundation for distinguished contribution to international MS<ref>{{Cite web|title=International Mass Spectronomy Foundation|url=https://www.imss.nl/awards.html|access-date=2020-12-18|website=www.imss.nl}}</ref>

2019     NWO-Physics Valorisation prize

2019     Brightlands Convention Award<ref>{{Cite web|last=Redactie|date=2019-03-27|title=Uitreiking Brightlands Convention Award 2018|url=https://conferencematters.nl/nl/uitreiking-brightlands-convention-award-2018/|access-date=2020-12-18|website=Conference Matters|language=nl-NL}}</ref>

2014     Robert Feulgen lecturer, Society for Histochemistry<ref>{{Cite web|title=Society for Histochemistry|url=http://www.histochemistry.eu/index.php?page=feulgen_lectures|access-date=2020-12-18|website=www.histochemistry.eu}}</ref>

2013     Winner, 10th Venture Challenge, Netherlands Genomics Initiative<ref>{{Cite web|last=|first=|date=|title=Press release: Omics2Image wins Venture Challenge Spring 2013|url=https://www.venturechallenge.nl/Mailings/Persbericht_VC_Spring2013.pdf|url-status=live|archive-url=|archive-date=|access-date=|website=}}</ref>

2012     Award, Exploratory Measurement Science Group (EMSG), University of Edinburgh, UK

2010     Distinguished Wiley Visiting Scientist award, Environmental Molecular Sciences Laboratory, Department of Energy, US<ref>{{Cite web|title=iDirector interview with Ron Heeren - YouTube|url=https://www.youtube.com/watch?v=vFt1CzN5Yvo|access-date=2020-12-18|website=www.youtube.com}}</ref><ref>{{Cite web|last=|first=|date=|title=New EMSL Visiting Scientists Named|url=https://www.emsl.pnnl.gov/News/new-emsl-visiting-scientists-named/71|url-status=live|archive-url=|archive-date=|access-date=|website=}}</ref>

2008     RCM Beynon Prize, Rapid Communications in Mass Spectrometry<ref>{{Cite web|title=Rapid Communications in Mass Spectrometry|url=https://onlinelibrary.wiley.com/page/journal/10970231/homepage/rcm_beynon_award.htm|access-date=2020-12-18|website=Wiley Online Library|language=en}}</ref>

2002     Bert L. Schram Award, Dutch Society for Mass Spectrometry (NVMS)

== Ten major publications ==
1.       ''Morphometric cell classification for single-cell MALDI-MSI''

Klára Šcupáková, Frédéric Dewez, Axel K. Walch, Ron M.A. Heeren, and Benjamin Balluff

Ang. Chemie Int. Ed. (2020) 59 17447 –17450Ščupáková, Klára; Dewez, Frédéric; Walch, Axel K.; Heeren, Ron M. A.; Balluff, Benjamin (2020-08-17). "Morphometric Cell Classification for Single‐Cell MALDI‐Mass Spectrometry Imaging". ''Angewandte Chemie International Edition''. '''59''' (40): 17447–17450. [[Doi (identifier)|doi]]:10.1002/anie.202007315. [[ISSN (identifier)|ISSN]]&nbsp;1433-7851<ref>{{Cite journal|last=Ščupáková|first=Klára|last2=Dewez|first2=Frédéric|last3=Walch|first3=Axel K.|last4=Heeren|first4=Ron M. A.|last5=Balluff|first5=Benjamin|date=2020-08-17|title=Morphometric Cell Classification for Single‐Cell MALDI‐Mass Spectrometry Imaging|url=http://dx.doi.org/10.1002/anie.202007315|journal=Angewandte Chemie International Edition|volume=59|issue=40|pages=17447–17450|doi=10.1002/anie.202007315|issn=1433-7851}}</ref>

2.       Automated, Parallel Mass Spectrometry Imaging and Structural Identification of Lipids

Shane R. Ellis, Martin R. L. Paine, Gert B. Eijkel, Peter Husen, Martin Hermansson, Christer S. Ejsing and Ron M. A. Heeren

Nature Methods (2018) 15 515-518

3.       Unambiguous identification and high resolution imaging of a-tocopherol from single cells to whole animals by ToF-SIMS Tandem Mass Spectrometry.

Anne L. Bruinen, Gregory L. Fisher, Rachelle Balez, Astrid M. van der Sar, Lezanne Ooi, Ron M.A. Heeren

JASMS (2018) 29 1571-1581

4.       Spatial systems lipidomics reveals nonalcoholic fatty liver disease heterogeneity

Klára Šcupáková, Zita Soons, Gökhan Ertaylan, Keely A. Pierzchalski, Gert B. Eijkel, Shane R. Ellis, Jan W. Greve, Ann Driessen, Joanne Verheij, Theo M. De Kok, Steven W.M. Olde Damink, Sander S. Rensen, and Ron M.A. Heeren

Analytical Chemistry (2018) 90 5130-5138

5.       Laser Post-Ionisation Combined with a High Resolving Orbitrap Mass Spectrometer for Enhanced MALDI-MS Imaging of Lipids

Shane R. Ellis, Jens Soltwisch, Martin R.L. Paine, K. Dreisewerd and Ron M.A. Heeren

Chem. Comm. (2017) 53 7246-7249  

6.       Use of Advantageous, Volatile Matrices Enabled by High Speed Next Generation MALDI-ToF Imaging Employing a Scanning Laser Beam.

Nina Ogrinc Potocnik, Tiffany Porta, Michael Becker, Ron M. A. Heeren and Shane R. Ellis

Rap. Comm. Mass Spec. (2015) 29 2195-2203

7.       A Enhanced Detection of High Mass Proteins Using an Active Pixel Detector

Shane R. Ellis, Julia H. Jungmann, Donald F. Smith, Jens Soltwisch.and Ron M. A. Heeren

Ang. Chemie. Int. Ed. (2013) 52 11261-11264

8.        Biological Tissue Imaging with a Position and Time Sensitive Pixelated Detector

Julia H. Jungmann, Donald F. Smith, Luke MacAleese, Ivo Klinkert, Jan Visser and Ron M.A. Heeren

J. Am. Soc. Mass Spec. (2012) 23 1679-1688


== References ==
== References ==

Revision as of 12:39, 18 December 2020

Ron M.A. Heeren (1965, Tilburg) is a Dutch scientist in mass spectrometry imaging. He is currently a distinguished professor at Maastricht University and the scientific director of the Multimodal Molecular Imaging Institute (M4I), where he heads the division of Imaging Mass Spectrometry.

Scientific career

Ron Heeren obtained a PhD degree in Technical Physics at the University of Amsterdam in 1992 under the supervision of Aart Kleyn. He led a FOM-AMOLF research group focusing on macromolecular ion physics and biomolecular imaging mass spectrometry (1995–2014). He was also appointed as professor at the chemistry faculty of Utrecht University in 2001–2019.

Between 1995 and 2015, he developed new approaches towards high spatial resolution and high-throughput molecular imaging mass spectrometry using secondary ion mass spectrometry (SIMS) and matrix-assisted laser desorption and ionization (MALDI).

From 2008 to 2013, Heeren was the research director for emerging technologies at the Netherlands Proteomics Centre. In 2012, he co-founded Omics2Image B.V., a company focused on bringing innovative ion detector technology to the analytical market. In 2014, he was appointed to his current position as one of the scientific directors of M4I at Maastricht University.

Heeren is an active member in numerous professional societies related to his field, including Dutch Physics Society (1993), The American Chemical Society (2010), The American Society for Mass Spectrometry (1994). Heeren was president of the Dutch Society of Mass Spectrometry between 2001–2005[1]. He is one of the founding members of the Mass Spectrometry Imaging Society, and was elected its president in 2017. For his “contributions to the mass spectrometry internationally” over his 30-year career, Heeren was awarded the Thomson Medal by the International Mass Spectrometry Society.[2]

Heeren has coauthored over 300 peer-reviewed articles, which have been cited over 12,600 times (Google Scholar; h index = 58).[3]

Valorization

Heeren has translated his innovations and scientific findings to patented techniques and instruments throughout his career. To date, he holds 7 patents (Placeholder5) and has established two spin-off companies, Omics2Image/ASI and the Dutch Screening Group. In 2019, Heeren was awarded the NWO Valorisation Prize in Physics[4] in recognition of his career-long efforts to “researcher [who] has managed to turn the results of their own research into something useful for society."[5]

Research

Heeren’s academic research interests are the fundamental studies of the energetics of macromolecular systems, conformational studies of non-covalently bound protein complexes, translational imaging research, high-throughput bioinformatics, and the development and validation of new mass spectrometry–based proteomic imaging techniques for the life sciences.

During his postdoctoral fellowship, he worked on the development of innovative ion sources, vacuums systems, data acquisition systems and novel temperature-controlled ion cyclotron resonance cells. He used the FTICR-MS instrument for the study of collisional energy transfer and internal energy distributions.[6][7][8] These methods were deployed to investigate their role in the determination of dissociation pathways of biomolecular systems.[9][10]

As a project leader (1995–1997), Heeren led the application of high-resolution MS (FTICR-MS, FTIR imaging spectroscopy and SIMS) to the field of conservation science. He discovered and identified saponified pigment particulates in so-called protrusions in Rembrandt’s “The Anatomy Lesson of Dr. Nicolaes Tulp” in collaboration with the Mauritshuis museum in The Hague.[11][12][13]

Heeren and his group have pioneered the development of active pixelated detectors for mass spectrometry imaging. One such detector, the Medipix detector has been adapted to enable microscope-mode imaging mass spectrometry[14] for biomolecules to enable combined high-throughput and high-resolution molecular imaging using MALDI and SIMS.

Education

Prof. Heeren is only one of four distinguished professors at UM.[15] He has supervised more than 60 PhD students and postdoctoral fellows, many of whom have received prestigious awards (NWO-Vidi and ERC grants, for example). Currently, he supervises masters and PhD students at UM, Vrije Universiteit Amsterdam, and the University of Amsterdam.

He delivered a tutorial lecture on Imaging MS at the 2014 annual ASMS conference[16] and a TEDx Maastricht talk[17].

Prof. Heeren is part of the organizing committee of the annual Mass Spectrometry School in Biotechnology and Medicine summer school in Dubrovnik. He has designed and established a molecular imaging track in the Biomedical Sciences Master programme and is coordinating the establishment of a new Molecular Imaging and Engineering Master program at UM.

Awards

2020     Hans Fisher Senior Fellowship, Institute of Advanced Studies, Technical University of Munich Hans Fisher senior fellowship[18]

2020     Thomson medal, International Mass Spectrometry Foundation for distinguished contribution to international MS[19]

2019     NWO-Physics Valorisation prize

2019     Brightlands Convention Award[20]

2014     Robert Feulgen lecturer, Society for Histochemistry[21]

2013     Winner, 10th Venture Challenge, Netherlands Genomics Initiative[22]

2012     Award, Exploratory Measurement Science Group (EMSG), University of Edinburgh, UK

2010     Distinguished Wiley Visiting Scientist award, Environmental Molecular Sciences Laboratory, Department of Energy, US[23][24]

2008     RCM Beynon Prize, Rapid Communications in Mass Spectrometry[25]

2002     Bert L. Schram Award, Dutch Society for Mass Spectrometry (NVMS)

Ten major publications

1.       Morphometric cell classification for single-cell MALDI-MSI

Klára Šcupáková, Frédéric Dewez, Axel K. Walch, Ron M.A. Heeren, and Benjamin Balluff

Ang. Chemie Int. Ed. (2020) 59 17447 –17450Ščupáková, Klára; Dewez, Frédéric; Walch, Axel K.; Heeren, Ron M. A.; Balluff, Benjamin (2020-08-17). "Morphometric Cell Classification for Single‐Cell MALDI‐Mass Spectrometry Imaging". Angewandte Chemie International Edition. 59 (40): 17447–17450. doi:10.1002/anie.202007315. ISSN 1433-7851[26]

2.       Automated, Parallel Mass Spectrometry Imaging and Structural Identification of Lipids

Shane R. Ellis, Martin R. L. Paine, Gert B. Eijkel, Peter Husen, Martin Hermansson, Christer S. Ejsing and Ron M. A. Heeren

Nature Methods (2018) 15 515-518

3.       Unambiguous identification and high resolution imaging of a-tocopherol from single cells to whole animals by ToF-SIMS Tandem Mass Spectrometry.

Anne L. Bruinen, Gregory L. Fisher, Rachelle Balez, Astrid M. van der Sar, Lezanne Ooi, Ron M.A. Heeren

JASMS (2018) 29 1571-1581

4.       Spatial systems lipidomics reveals nonalcoholic fatty liver disease heterogeneity

Klára Šcupáková, Zita Soons, Gökhan Ertaylan, Keely A. Pierzchalski, Gert B. Eijkel, Shane R. Ellis, Jan W. Greve, Ann Driessen, Joanne Verheij, Theo M. De Kok, Steven W.M. Olde Damink, Sander S. Rensen, and Ron M.A. Heeren

Analytical Chemistry (2018) 90 5130-5138

5.       Laser Post-Ionisation Combined with a High Resolving Orbitrap Mass Spectrometer for Enhanced MALDI-MS Imaging of Lipids

Shane R. Ellis, Jens Soltwisch, Martin R.L. Paine, K. Dreisewerd and Ron M.A. Heeren

Chem. Comm. (2017) 53 7246-7249  

6.       Use of Advantageous, Volatile Matrices Enabled by High Speed Next Generation MALDI-ToF Imaging Employing a Scanning Laser Beam.

Nina Ogrinc Potocnik, Tiffany Porta, Michael Becker, Ron M. A. Heeren and Shane R. Ellis

Rap. Comm. Mass Spec. (2015) 29 2195-2203

7.       A Enhanced Detection of High Mass Proteins Using an Active Pixel Detector

Shane R. Ellis, Julia H. Jungmann, Donald F. Smith, Jens Soltwisch.and Ron M. A. Heeren

Ang. Chemie. Int. Ed. (2013) 52 11261-11264

8.        Biological Tissue Imaging with a Position and Time Sensitive Pixelated Detector

Julia H. Jungmann, Donald F. Smith, Luke MacAleese, Ivo Klinkert, Jan Visser and Ron M.A. Heeren

J. Am. Soc. Mass Spec. (2012) 23 1679-1688

References

  1. ^ "History". NVMS. Retrieved 2020-12-18.
  2. ^ Maastricht, Minderbroedersberg 4-6 6211 LK. "Thomson Medal 2020 awarded to Ron Heeren". www.maastrichtuniversity.nl. Retrieved 2020-12-18.{{cite web}}: CS1 maint: numeric names: authors list (link)
  3. ^ "Ron M.A. Heeren". scholar.google.nl. Retrieved 2020-12-18.
  4. ^ "NWO Physics Valorisation Prize 2019 - Ron Heeren - YouTube". www.youtube.com. Retrieved 2020-12-18.
  5. ^ "NWO Physics Valorisation Prize goes to Ron Heeren from Maastricht University | NWO". www.nwo.nl. Retrieved 2020-12-18.
  6. ^ Heeren, Ron M. A.; Vékey, Károly (1998-09-15). <1175::aid-rcm305>3.0.co;2-l "A novel method to determine collisional energy transfer efficiency by Fourier transform ion cyclotron resonance mass spectrometry". Rapid Communications in Mass Spectrometry. 12 (17): 1175–1181. doi:10.1002/(sici)1097-0231(19980915)12:17<1175::aid-rcm305>3.0.co;2-l. ISSN 0951-4198.
  7. ^ Drahos, null; Heeren, null; Collette, null; De Pauw E, null; Vekey, null (1999-12). "Thermal energy distribution observed in electrospray ionization". Journal of mass spectrometry: JMS. 34 (12): 1373–1379. doi:10.1002/(SICI)1096-9888(199912)34:123.0.CO;2-#. ISSN 1096-9888. PMID 10587635. {{cite journal}}: Check date values in: |date= (help)
  8. ^ Guo, Xinghua; Duursma, Marc C.; Kistemaker, Piet G.; Nibbering, Nico M. M.; Vekey, Karoly; Drahos, Laszlo; Heeren, Ron M. A. (2003-06). "Manipulating internal energy of protonated biomolecules in electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry". Journal of mass spectrometry: JMS. 38 (6): 597–606. doi:10.1002/jms.480. ISSN 1076-5174. PMID 12827629. {{cite journal}}: Check date values in: |date= (help)
  9. ^ Koster, Sander; Duursma, Marc C.; Boon, Jaap J.; Nielen, Michel W. F.; de Koster, Chris G.; Heeren, Ron M. A. (2000). <739::aid-jms3>3.0.co;2-# "Structural analysis of synthetic homo- and copolyesters by electrospray ionization on a Fourier transform ion cyclotron resonance mass spectrometer". Journal of Mass Spectrometry. 35 (6): 739–748. doi:10.1002/1096-9888(200006)35:6<739::aid-jms3>3.0.co;2-#. ISSN 1076-5174.
  10. ^ Kleinnijenhuis, Anne J.; Duursma, Marc C.; Breukink, Eefjan; Heeren, Ron M. A.; Heck, Albert J. R. (2003-07-01). "Localization of intramolecular monosulfide bridges in lantibiotics determined with electron capture induced dissociation". Analytical Chemistry. 75 (13): 3219–3225. doi:10.1021/ac0263770. ISSN 0003-2700. PMID 12964772.
  11. ^ Heeren, Ron M. A.; Boon, Jaap J.; Noble, Petria; Wadum, Jørgen (1999). "Integrating imaging FTIR and secondary ion mass spectrometry for the analysis of embedded paint cross-sections". ICOM-CC Triennial meeting (12th), Lyon, 29 August-3 September 1999: preprints.: 228–233.
  12. ^ "Recitative after Rembrandt's "The Anatomy Lesson of Dr. Nicolaes Tulp"", 90 Miles, University of Pittsburgh Press, pp. 78–79, 2005-03-23, ISBN 978-0-8229-8033-9, retrieved 2020-12-18
  13. ^ Van Der Weerd, J.; Brammer, H.; Boon, J. J.; Heeren, R. M. A. (2002-03). "Fourier Transform Infrared Microscopic Imaging of an Embedded Paint Cross-Section". Applied Spectroscopy. 56 (3): 275–283. doi:10.1366/0003702021954683. ISSN 0003-7028. {{cite journal}}: Check date values in: |date= (help)
  14. ^ Jungmann, Julia H.; MacAleese, Luke; Visser, Jan; Vrakking, Marc J. J.; Heeren, Ron M. A. (2011-10-15). "High Dynamic Range Bio-Molecular Ion Microscopy with the Timepix Detector". Analytical Chemistry. 83 (20): 7888–7894. doi:10.1021/ac2017629. ISSN 0003-2700.
  15. ^ "Distinguished university professors - Research - Maastricht University". www.maastrichtuniversity.nl. Retrieved 2020-12-18.
  16. ^ ASMS (2014-09-06), Imaging MS: 2014 Tutorial, Ron M.A. Heeren, retrieved 2020-12-18
  17. ^ "The New Dawn of Cancer Surgery | Ron Heeren | TEDxMaastricht - YouTube". www.youtube.com. Retrieved 2020-12-18.
  18. ^ "Heeren, Ron M.A. - Institute for Advanced Study (IAS)". www.ias.tum.de (in German). Retrieved 2020-12-18.
  19. ^ "International Mass Spectronomy Foundation". www.imss.nl. Retrieved 2020-12-18.
  20. ^ Redactie (2019-03-27). "Uitreiking Brightlands Convention Award 2018". Conference Matters (in Dutch). Retrieved 2020-12-18.
  21. ^ "Society for Histochemistry". www.histochemistry.eu. Retrieved 2020-12-18.
  22. ^ "Press release: Omics2Image wins Venture Challenge Spring 2013" (PDF).{{cite web}}: CS1 maint: url-status (link)
  23. ^ "iDirector interview with Ron Heeren - YouTube". www.youtube.com. Retrieved 2020-12-18.
  24. ^ "New EMSL Visiting Scientists Named".{{cite web}}: CS1 maint: url-status (link)
  25. ^ "Rapid Communications in Mass Spectrometry". Wiley Online Library. Retrieved 2020-12-18.
  26. ^ Ščupáková, Klára; Dewez, Frédéric; Walch, Axel K.; Heeren, Ron M. A.; Balluff, Benjamin (2020-08-17). "Morphometric Cell Classification for Single‐Cell MALDI‐Mass Spectrometry Imaging". Angewandte Chemie International Edition. 59 (40): 17447–17450. doi:10.1002/anie.202007315. ISSN 1433-7851.
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