Interleukin 20

IL20
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4DOH
Identifiers
Aliases	IL20, IL-20, IL10D, ZCYTO10, Interleukin 20
External IDs	OMIM: 605619; MGI: 1890473; HomoloGene: 10286; GeneCards: IL20; OMA:IL20 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q32.1 Start 206,865,354 bp End 206,869,223 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 E4 Start 130,834,722 bp End 130,839,188 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad pancreatic ductal cell seminal vesicula smooth muscle tissue stromal cell of endometrium olfactory zone of nasal mucosa left uterine tube skin of abdomen myometrium skin of limb Top expressed in zygote secondary oocyte primary oocyte right ventricle artery mammillary body ventral tegmental area skin of abdomen carotid body major salivary gland More reference expression data BioGPS n/a
Gene ontology Molecular function interleukin-20 receptor binding signaling receptor binding cytokine activity interleukin-22 receptor binding protein binding Cellular component extracellular region extracellular space Biological process positive regulation of keratinocyte differentiation positive regulation of osteoclast differentiation positive regulation of epidermal cell differentiation regulation of inflammatory response positive regulation of tyrosine phosphorylation of STAT protein regulation of signaling receptor activity cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50604 58181 Ensembl ENSG00000162891 ENSMUSG00000026416 UniProt Q9NYY1 Q9JKV9 RefSeq (mRNA) NM_018724 NM_021380 NM_001311091 RefSeq (protein) NP_061194 NP_001298020 NP_067355 Location (UCSC) Chr 1: 206.87 – 206.87 Mb Chr 1: 130.83 – 130.84 Mb PubMed search
Wikidata
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Interleukin 20 (IL20) is a protein that in humans is encoded by the IL20 gene. Interkeukin 20 also includes other cytokines, including IL-19, IL-20, IL-22, IL-24, and IL-26. Based on common structural and functional properties of IL-20's receptors and target cells, these cytokines constitute the same subfamily, IL-20.

Function

The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL-10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.

Interleukin-20 (IL-20) is a protein belonging to the IL-10 family of cytokines. IL-20 is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells. IL-20 regulates proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin. In addition, IL-20 also causes cell expansion of multipotential hematopoietic progenitor cells.

Anti IL-20

Anti-IL-20 monoclonal antibodies have been researched as clinical candidates for the treatment or prevention of psoriasis, rheumatoid arthritis, atherosclerosis, osteoporosis, and stroke.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9NYY1 (Interleukin-20) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.