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Norleucine

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Norleucine
Names
IUPAC name
(2S)-2-aminohexanoic acid
Other names
Caprine

Glycoleucine L-Norleucine

2-Aminocaproic acid
Identifiers
3D model (JSmol)
1721748
ChEBI
ChemSpider
DrugBank
ECHA InfoCard 100.009.512 Edit this at Wikidata
EC Number
  • 210-462-7
464584
KEGG
MeSH Norleucine
RTECS number
  • RC6308000
UNII
  • InChI=1S/C6H13NO2/c1-2-3-4-5(7)6(8)9/h5H,2-4,7H2,1H3,(H,8,9)
    Key: LRQKBLKVPFOOQJ-UHFFFAOYSA-N
  • CCCCC(N)C(O)=O
Properties
C6H13NO2
Molar mass 131.175 g·mol−1
Melting point 301 °C (decomposes) [1]
16 g/l at 23 °C [2]
Acidity (pKa) 2.39 (carboxyl), 9.76 (amino)[3]
Related compounds
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Norleucine (abbreviated as Nle) is an isomer of leucine, the α-amino acid 2-amino-hexanoic acid. It is not found in natural proteins. Norleucine is used in experimental studies of protein structure and function. It is structurally similar to methionine, however it does not contain sulfur.


See also

  • Leucines, description of the isomers of leucine

References

  1. ^ Hermann Römpp, Jürgen Falbe und Manfred Regitz: Römpp Lexikon Chemie, 9. Auflage, Georg Thieme Verlag, Stuttgart 1992.
  2. ^ Sicherheitsdatenblatt Acros.
  3. ^ Dawson, R.M.C., et al., Data for Biochemical Research, Oxford, Clarendon Press, 1959.
  4. ^ [1]
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