Janeway lesion
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| Janeway lesion | |
|---|---|
 | |
| Specialty | Infectious diseases  |
| Differential diagnosis | infective endocarditis |
Janeway lesions are non-tender, small erythematous or haemorrhagic macular or nodular lesions on the palms or soles only a few millimeters in diameter that are indicative of infective endocarditis.[1][2]
Definition
Janeway lesions are painless, frequently haemorrhagic lesions seen most commonly on the palms and soles, particularly on the the base of the thumb and little finger, and seen in acute endocarditis.[3]
Differential
Osler's nodes and Janeway lesions are similar and point to the same diagnostic conclusion. The only noted difference between the two is that Osler's nodes present with tenderness, while Janeway lesions do not.[1]
Pathophysiology
Pathologically, the lesion is described to be a microabscess of the dermis with marked necrosis and inflammatory infiltrate not involving the epidermis.[1]
They are caused by septic emboli which deposit bacteria, forming microabscesses.[4] Janeway lesions are distal, flat, ecchymotic, and painless.[citation needed]
Diagnosis
Janeway lesions present as painless, non tender, subcutaneous maculopapular lesions on the pulp of the finger most commonly due to allergic or toxic inflammation of the vessel wall.[citation needed]
Not commonly seen, they are also often indistinguishable from Osler's nodes.[1]
They may last days to weeks before completely resolving.[3]
Etymology
Janeway lesions are named after Edward Janeway (1841–1911), a prominent American physician and pathologist who initially described the lesions.[citation needed]
See also
References
- ^ a b c d Farrior, J.B.; Silverman M.E. (1976). "A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis". Chest. 70 (2): 239–243. doi:10.1378/chest.70.2.239. PMID 947688.
- ^ David Weedon (2010). Weedon's Skin Pathology, Churchill Livingstone, 3rd Edition. ISBN 9780702034855
- ^ a b "Osler nodes and Janeway lesions | DermNet NZ". www.dermnetnz.org. Retrieved 2 October 2019.
{{cite web}}: CS1 maint: url-status (link) - ^ Mandell, Douglas, Bennett's Principles and Practice of Infectious Diseases, 7th ed., Churchill Livingstone (2009).
External links
Template:Eponymous medical signs for circulatory and respiratory systems