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David Siderovski

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David Siderovski
Alma mater
AwardsASPET's John J. Abel Award in 2004
Scientific career
FieldsBiochemistry
Pharmacology
Medical education
InstitutionsAmgen Research Institute
University of North Carolina at Chapel Hill
West Virginia University
ThesisHuman Immunodeficiency Virus Type-1 Trans-activator of Transcription (HIV-1 Tat) (1997)
Doctoral advisorTak Wah Mak
Other academic advisorsAlfred G. Gilman
Robert J. Lefkowitz

David Siderovski is a North American pharmacologist with an Abel Number of 5.[1] From 2012 to 2019, he was the E.J. Van Liere Medicine Professor and Chair of Physiology, Pharmacology & Neuroscience for the West Virginia University School of Medicine[2]; since July 2015, Siderovski has been the interim co-director of the WVU Addictions Research Group, part of WVU's Rockefeller Neurosciences Institute.[3]

Education

Siderovski attended Earl Haig Secondary School in North York, Ontario, and graduated in 1985.

In 1989, Siderovski graduated with a BS from Queen's University in Kingston, Ontario.[4]

David Siderovski, outside Summerhill House (Queen's University, Kingston, ON), holding the 1989 Prince of Wales Prize
David Siderovski, outside Summerhill House (Queen's University, Kingston, ON), holding the 1989 HRH Prince of Wales Prize

Siderovski began his PhD training at the University of Toronto in May 1989. During his fifth year of his PhD, he began full-time work as a research scientist in the Quantitative Biology Laboratory of the Amgen Research Institute, Toronto.[5] He successfully defended his PhD thesis in November 1997.[6] He left the Amgen Research Institute in December 1998, having contributed to three patents as a co-inventor.[7][8][9]

Career

After completing his industrial postdoctoral position at the Amgen Research Institute in 1998,[5] Siderovski joined the faculty at the University of North Carolina at Chapel Hill as a tenure-track assistant professor of pharmacology. His earliest publications, starting with a brief original report in Current Biology,[10] chronicle his independent discovery[11] of the RGS protein superfamily,[12][13][14] and determinations of their varied protein structures[15][16] and cellular functions.[17] One of these early reports[15] was co-authored by two Nobel laureates: Alfred G. Gilman and Robert Lefkowitz.

In 2004, Siderovski was named the top American Pharmacologist under 40 and awarded the John J. Abel Award by the American Society for Pharmacology and Experimental Therapeutics.[18]

From 2006 to 2012, Siderovski was the Thomas J. Dark Basic Science Director of UNC's Medical Scientist Training Program and directly responsible for assisting MD/PhD combined-degree trainees through their progress to PhD completion.[19] In August 2014, Siderovski was appointed Director of the West Virginia University School of Medicine MD/PhD Scholars Program.[20] Siderovski has been serving as Editorial Board Member for the Journal of Biological Chemistry since 2012.[21]

References

  1. ^ "Abel Numbers" (PDF). ASPET.org. May 30, 2019. Retrieved November 21, 2019.{{cite web}}: CS1 maint: url-status (link)
  2. ^ Mcmurtrie, Beth (2017-10-01). "One University Takes On the Opioid Crisis". The Chronicle of Higher Education. ISSN 0009-5982. Retrieved 2019-11-21.
  3. ^ "WVU Centers for Neuroscience". WVU Centers for Neuroscience. Retrieved 30 August 2015.
  4. ^ "Prince of Wales Prizes". Automatic Awards Open to All Upper Year Students. Queen's University. Retrieved 11 August 2015.
  5. ^ a b "Can You Go Home Again? | The Scientist Magazine®". The Scientist. Retrieved 2016-06-09.
  6. ^ Siderovski, David Peter (1997). Human immunodeficiency virus type-1 trans-activator of transcription (HIV-1 Tat): Random mutagenesis and interaction with PKR (PDF). University of Toronto. Retrieved 2015-08-04.
  7. ^ "Methods of modulating T-cell activation WO 1997041438 A1". Retrieved 9 August 2015.
  8. ^ "Apoptosis-inducing factor CA 2352467 A1". Retrieved 9 August 2015.
  9. ^ "Apoptosis-inducing factor CA 2352467 C". Retrieved 9 August 2015.
  10. ^ Siderovski DP, Hessel A, Chung S, Mak TW, Tyers M (February 1996). "A new family of regulators of G-protein-coupled receptors?". Curr Biol. 6 (2): 211–2. doi:10.1016/S0960-9822(02)00454-2. PMID 8673468.
  11. ^ Roush, W. (1996-02-23). "Cell Biology: Regulating G Protein Signaling". Science. 271 (5252): 1056–1058. doi:10.1126/science.271.5252.1056. ISSN 0036-8075.
  12. ^ Snow BE, Antonio L, Suggs S, Gutstein HB, Siderovski DP (April 1997). "Molecular cloning and expression analysis of rat Rgs12 and Rgs14". Biochem Biophys Res Commun. 233 (3): 770–7. doi:10.1006/bbrc.1997.6537. PMID 9168931.
  13. ^ Snow BE, Antonio L, Suggs S, Siderovski DP (January 1998). "Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene". Gene. 206 (2): 247–53. doi:10.1016/s0378-1119(97)00593-3. PMID 9469939.
  14. ^ Siderovski DP, Strockbine B, Behe CI (1999). "Whither goest the RGS proteins?". Crit Rev Biochem Mol Biol. 34 (4): 215–51. doi:10.1080/10409239991209273. PMID 10517644.
  15. ^ a b Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (July 1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". J Biol Chem. 273 (28): 17749–55. doi:10.1074/jbc.273.28.17749. PMID 9651375.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  16. ^ Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP (October 1998). "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits". Proceedings of the National Academy of Sciences of the United States of America. 95 (22): 13307–12. Bibcode:1998PNAS...9513307S. doi:10.1073/pnas.95.22.13307. PMC 23793. PMID 9789084.
  17. ^ Ingi T, Krumins AM, Chidiac P, Brothers GM, Chung S, Snow BE, Barnes CA, Lanahan AA, Siderovski DP, et al. (September 1998). "Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity". J Neurosci. 18 (18): 7178–88. doi:10.1523/JNEUROSCI.18-18-07178.1998. PMID 9736641.
  18. ^ ASPET (2004-01-01). "ASPET Award Winners for 2004" (PDF). ASPET. Archived from the original (PDF) on 2015-06-26. Retrieved 2015-08-04.
  19. ^ "Leadership". UNC MD-PhD Program (circa March 24, 2012). Internet Archive Wayback Machine. Archived from the original on March 24, 2012. Retrieved 12 August 2015.
  20. ^ "Siderovski Chosen to Oversee M.D./PH.D. Scholars Program". School of Medicine > Home > News > Story. WVU School of Medicine. Retrieved 13 August 2015.
  21. ^ "JBC Editorial Board".
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