Epratuzumab
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Humanized (from mouse) |
| Target | CD22 |
| Clinical data | |
| Trade names | LymphoCide |
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| Legal status | |
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Epratuzumab (planned trade name LymphoCide) is a humanized monoclonal antibody. Potential uses may be found in oncology and in treatment of inflammatory autoimmune disorders, such as systemic lupus erythematosus (SLE).[1][2] The manufacturers in August 2009 announced success in early trials against SLE,[3] and the drug is in Phase III clinical trials as of February 2014[update].[4]
Mechanism of action
Epratuzumab binds to the glycoprotein CD22 of mature and malignant B-cells.
References
- ^ Epratuzumab, a humanized monoclonal antibody targeting CD22: characterization of in vitro properties Clinical Cancer Research Vol. 9, September 1, 2003 free full text
- ^ Dose-Fractionated Radioimmunotherapy in Non-Hodgkin's Lymphoma Using DOTA-Conjugated, 90Y-Radiolabeled, Humanized Anti-CD22 Monoclonal Antibody, Epratuzumab Clinical Cancer Research Vol. 11, July 15, 2005 free full text
- ^ Reuters: UCB and Immunomedics Announce Positive Results for Epratuzumab Phase IIb Study in Systemic Lupus Erythematosus (SLE)
- ^ H. Spreitzer (3 February 2014). "Neue Wirkstoffe – Epratuzumab". Österreichische Apothekerzeitung (in German) (3/2014): 28.
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