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API5

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This is an old revision of this page, as edited by 210.179.96.71 (talk) at 05:00, 16 April 2018 (References). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

API5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAPI5, AAC-11, AAC11, apoptosis inhibitor 5
External IDsOMIM: 609774; MGI: 1888993; HomoloGene: 4809; GeneCards: API5; OMA:API5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001142930
NM_001142931
NM_001243747
NM_006595

NM_007466
NM_001305258
NM_001349003

RefSeq (protein)

NP_001136402
NP_001136403
NP_001230676
NP_006586

NP_001292187
NP_031492
NP_001335932

Location (UCSC)Chr 11: 43.31 – 43.34 MbChr 2: 94.24 – 94.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The human gene API5 encodes the protein Apoptosis inhibitor 5.[5][6]

This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of chemotherapeutic drugs.

Diseases associated with API5 include colon adenocarcinoma, and cervical cancer.

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[7]==References==

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166181Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027193Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R (Oct 1997). "AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal". Cancer Res. 57 (18): 4063–9. PMID 9307294.
  6. ^ "Entrez Gene: API5 apoptosis inhibitor 5".
  7. ^ Han, BG. "Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules". J. Biol. Chem. 287: 10727. doi:10.1074/jbc.M111.317594.. PMID 22334682. {{cite journal}}: Check |doi= value (help)

Further reading

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