This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of chemotherapeutic drugs. Crystal structure of API5 exhibited the function for protein-protein interaction [7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R (Oct 1997). "AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal". Cancer Res. 57 (18): 4063–9. PMID9307294.
^Han, BG; et al. "Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules". J. Biol. Chem. 287: 10727-37. doi:10.1074/jbc.M111.317594.. PMID22334682. {{cite journal}}: Check |doi= value (help); Explicit use of et al. in: |first1= (help)CS1 maint: extra punctuation (link)
Han, BG; et al. "Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules". J. Biol. Chem. 287: 10727-37. doi:10.1074/jbc.M111.317594.. PMID22334682. {{cite journal}}: Check |doi= value (help); Explicit use of et al. in: |first1= (help)CS1 maint: extra punctuation (link)
