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SARS-CoV-2 Delta variant

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Lineage B.1.617, also known as Variant under investigation (VUI-21APR-01) is one of the variants of SARS-CoV-2, the virus that causes COVID-19.[1] It was first identified in India on 5 October 2020 and is a "double mutation" variant.[2][3][4]

Mutations

The B.1.617 genome has at least 15 mutations with two specific mutations in the spike protein which define it:[5]

  • E484Q
  • L425R

The two mutations taken separately are not unique to this variant, but the occurrence of both of them in the same variant is unique to the genomes identified in India.[3]

There is also a third significant defining mutation:

  • P614R

Statistics

By 20 April 2021, 800 sequences of the variant had been detected in 21 countries.[2] Among these, countries with most detections were:

Cases by country (Updated as of 20 April 2021)
Country Confirmed cases First detection References
 India 162 1 March 2021 [6]
 United Kingdom 103 14 April 2021 [7][8]
 USA 6 12 April 2021 [6]
World (3 countries) Total: 271 Total as of 20 April 2021

See also

References

  1. ^ "Confirmed cases of COVID-19 variants identified in UK". www.gov.uk. 15 April 2021. Retrieved 19 April 2021.
  2. ^ a b "PANGO lineages Lineage B.1.617". cov-lineages.org. Retrieved 19 April 2021.
  3. ^ a b Koshy, Jacob (8 April 2021). "Coronavirus | Indian 'double mutant' strain named B.1.617". The Hindu. Retrieved 19 April 2021.
  4. ^ Cuff, Madeleine (19 April 2021). "Indian variant: Cases of new 'double mutation' Covid strain thought to be spreading in UK". i (newspaper). London. Retrieved 20 April 2021.
  5. ^ Sample, Ian (19 April 2021). "What do we know about the Indian coronavirus variant?". The Guardian. London. Retrieved 20 April 2021.
  6. ^ a b Haseltine, William A. (12 April 2021). "An Indian SARS-CoV-2 Variant Lands In California. More Danger Ahead?". Forbes. USA. Retrieved 20 April 2021.
  7. ^ Davis, Nicola (15 April 2021). "Covid variant first detected in India is found in the UK". The Guardian. London. Retrieved 20 April 2021.
  8. ^ "Covid-19: India added to coronavirus 'red list' for travel". BBC News. London. 19 April 2021. Retrieved 20 April 2021.
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