C11orf53
Chromosome 11 open reading frame 53 is a protein that in humans is encoded by the C11orf53 gene.[1] Reduction in C11orf53 gene expression is associated with increased odds of occurrence of colorectal cancer.[2] Specifically sequence variation (rs3802842) close to the C11orf53 gene locus that lowers the expression of C11orf53 has been observed in the colonic mucosal cells immediately adjacent to colon cancer tumors.[3][4] C11orf53 downregulation aids in cells' ability to survive in acidic conditions, which are typical of the tumor microenvironment. [5] CRISPR-Cas9 inactivation of C11orf53 in an acute myeloid leukemia cell line made the cells resistant to the BCL2 inhibitor Ventoclax, further supporting a role in cancer predisposition.[6][7]
Additional roles have been proposed.[8][9]
References
- ^ ""C11orf53 chromosome 11 open reading frame 53 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov.
- ^ Delgado, Ana Paula; Brandao, Pamela; Chapado, Maria Julia; Hamid, Shelin; Narayanan, Ramaswamy (July 2014). "Open Reading Frames Associated with Cancer in the Dark Matter of the Human Genome". Cancer Genomics & Proteomics. 11 (4): 201–213. PMID 25048349.
- ^ Biancolella, M; Fortini, BK; Tring, S; Plummer, SJ; Mendoza-Fandino, GA; Hartiala, J; Hitchler, MJ; Yan, C; Schumacher, FR; Conti, DV; Edlund, CK; Noushmehr, H; Coetzee, SG; Bresalier, RS; Ahnen, DJ; Barry, EL; Berman, BP; Rice, JC; Coetzee, GA; Casey, G (15 April 2014). "Identification and characterization of functional risk variants for colorectal cancer mapping to chromosome 11q23.1". Human molecular genetics. 23 (8): 2198–209. doi:10.1093/hmg/ddt584. PMC 3959808. PMID 24256810.
- ^ Closa, A; Cordero, D; Sanz-Pamplona, R; Solé, X; Crous-Bou, M; Paré-Brunet, L; Berenguer, A; Guino, E; Lopez-Doriga, A; Guardiola, J; Biondo, S; Salazar, R; Moreno, V (September 2014). "Identification of candidate susceptibility genes for colorectal cancer through eQTL analysis". Carcinogenesis. 35 (9): 2039–46. doi:10.1093/carcin/bgu092. PMC 4146415. PMID 24760461.
- ^ Funato, Y; Yoshida, A; Hirata, Y; Hashizume, O; Yamazaki, D; Miki, H (2020). "The oncogenic PRL protein causes acid addiction of cells by stimulating lysosomal exocytosis". Developmental Cell. 55 (4): 387–397. doi:10.1016/j.devcel.2020.08.009. PMID 32918875.
- ^ "C11orf53 CRISPR Screens (Homo sapiens)". orcs.thebiogrid.org.
- ^ Nechiporuk, T; Kurtz, SE; Nikolova, O; Liu, T; Jones, CL; D'Alessandro, A; Culp-Hill, R; d'Almeida, A; Joshi, SK; Rosenberg, M; Tognon, CE; Danilov, AV; Druker, BJ; Chang, BH; McWeeney, SK; Tyner, JW (July 2019). "The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells". Cancer discovery. 9 (7): 910–925. doi:10.1158/2159-8290.CD-19-0125. PMC 6606338. PMID 31048320.
- ^ "C11orf53 chromosome 11 open reading frame 53 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov.
- ^ Oláh, J; Vincze, O; Virók, D; Simon, D; Bozsó, Z; Tõkési, N; Horváth, I; Hlavanda, E; Kovács, J; Magyar, A; Szũcs, M; Orosz, F; Penke, B; Ovádi, J (30 September 2011). "Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein". The Journal of biological chemistry. 286 (39): 34088–100. doi:10.1074/jbc.M111.243907. PMC 3190826. PMID 21832049.
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