Otto Neubauer

Otto Neubauer (8 April 1874 – 24 November 1957) was a Prussian physician and biochemist who was responsible for several clinical diagnostic innovations including the Neubauer-Fischer test to evaluate kidney function.

Neubauer was born in Karlsbad to physician Wolfgang and Hedwig Arnstein. Educated at the German University in Prague he received a doctorate in 1898 and became interested in physiological chemistry through the influence of Karl H. Huppert. He then joined as an assistant to Friedrich von Müller at Basel. He moved to Munich in 1902. In 1908 he joined the University of Munich and served in a reserve hospital during World War I. His major work in this period was on amino acid metabolism in human health and disease. Neubauer and Konrad Fromherz examined the role of pyruvic acid in fermentation. He innovated several clinical diagnostics including tests of peptolytic activity. Gastric juice incubated with glycyltryptophan for twenty four hours tested with bromine to see if free tryptophan causes a rose-violet colour was used as an indication of stomach carcinoma. In 1918 he became head physician at Schwabinger Hospital, working there until his dismissal by the Nazi government in June 1933 as a person of Jewish ancestry. In 1920 he developed a blood pressure measuring device and still later a measuring slide (known as a Neubauer slide) for counting cells under a microscope. In 1939, he emigrated to England along with his wife Lilly Caroline and worked in Oxford for the remainder of his life. His contributions included studies on arsenic and other chemicals as carcinogens.

Neubauer's students included Siegfried Thannhauser, Rudolf Schindler, and Konrad Döbereiner.