Talk:Melatonin

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Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Melatonin.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

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"Melatonin is rapidly absorbed and distributed, reaching peak plasma concentrations after 60 minutes of administration, and is then eliminated. Melatonin has a half life of 35–50 minutes."

How does that work? — Preceding unsigned comment added by Drsruli (talk • contribs) 14:47, 22 July 2019 (UTC)[reply]

We already have a section on this

And we provide a better summary of the evidence. Doc James (talk · contribs · email) 11:47, 24 January 2020 (UTC)[reply]

Alzheimer's disease

Hypothalamic nuclei, such as the suprachiasmatic nuclei and the lateral hypothalamic area, that are affected by β-amyloid plaques and neurofilament tangles in brains with Alzheimer's diseases are also involved in the severe disruption of the circadian rhythm and consequently, the occurrence of sleep disorders.^[1] Sleep disturbances as well as poor sleep quality may contribute to the development of Alzheimer's disease, to some degree through the facilitation of β-amyloid buildup (a risk factor for Alzheimer's disease) in the human brain.^[2]^[3] Research shows that in the pre-onset stages of Alzheimer's disease, melatonin levels in the CSF are significantly lower.^[1] Furthermore, there is evidence in transgenic animal models of Alzheimer's disease that the exogenous administration of melatonin not only decreases the production and/or deposition of β-amyloid peptide but also increases its clearance through the glymphatic system.^[4] Recent research concluded that exogenous melatonin administered in the preclinical phase of dementia demonstrates a significant increase in sleep quality and efficiency.^[1]

References

^ ^a ^b ^c Spinedi, Eduardo; Cardinali, Daniel P. (2019). "Neuroendocrine-Metabolic Dysfunction and Sleep Disturbances in Neurodegenerative Disorders: Focus on Alzheimer's Disease and Melatonin". Neuroendocrinology. 108 (4): 354–364. doi:10.1159/000494889. ISSN 0028-3835.
^ Spira, Adam P.; Gottesman, Rebecca F. (April 2017). "Sleep disturbance: an emerging opportunity for Alzheimer's disease prevention?". International Psychogeriatrics. 29 (4): 529–531. doi:10.1017/S1041610216002131. ISSN 1041-6102. PMC 5493989. PMID 27938445.
^ Brown, Belinda M.; Rainey-Smith, Stephanie R.; Villemagne, Victor L.; Weinborn, Michael; Bucks, Romola S.; Sohrabi, Hamid R.; Laws, Simon M.; Taddei, Kevin; Macaulay, S. Lance; Ames, David; Fowler, Christopher (2016-05-01). "The Relationship between Sleep Quality and Brain Amyloid Burden". Sleep. 39 (5): 1063–1068. doi:10.5665/sleep.5756. ISSN 0161-8105. PMC 4835305. PMID 27091528.
^ Shukla, Mayuri; Govitrapong, Piyarat; Boontem, Parichart; Reiter, Russel J.; Satayavivad, Jutamaad (2017-08-28). "Mechanisms of Melatonin in Alleviating Alzheimer's Disease". Current Neuropharmacology. 15 (7). doi:10.2174/1570159X15666170313123454. PMC 5652010. PMID 28294066.

Ordering

The ordering of this article follows WP:MEDMOS and has for some time. So restored. Doc James (talk · contribs · email) 16:44, 29 March 2020 (UTC)[reply]

COVID-19 and melatonin?

I think that the section should be removed. — Preceding unsigned comment added by 97.113.124.116 (talk) 05:47, 3 August 2020 (UTC) I agree that the research is too preliminary for an encyclopedia article and I deleted the entire section. Tachyon (talk) 12:38, 3 August 2020 (UTC)[reply]

Melatonin and the liver

"Its use is not recommended during pregnancy or breastfeeding or for those with liver disease.[7][13]"

New studies suggest that melatonin supplementation may be a promising adjunct for liver disease.

https://www.mdpi.com/2072-6643/10/9/1135 — Preceding unsigned comment added by Dreizweins (talk • contribs) 23:57, 8 September 2020 (UTC)[reply]

Orcid IDs

@Invasive Spices: Why are you adding Orcid IDs to citations? It polutes the meta data. You are also hyping the authors. Focus on the conclusions of the study, not who wrote it. Thanks. Boghog (talk) 19:06, 24 September 2021 (UTC)[reply]

That's pretty funny coming from someone who removes and damages as much author data as you can. As for hyping the authors, I normally don't and would agree that is inappropriate, however I do so if working from a rev and the rev thinks that paper is so singular as to be worth promoting. (Also I don't see any such on this article. But I've done that elsewhere.) Invasive Spices (talk) 19:20, 24 September 2021 (UTC)[reply]
- Again, I am trying to have a serious discussion, and you refuse to directly respond. Why does every single author deserve an external link to their other publications? Boghog (talk) 19:26, 24 September 2021 (UTC)[reply]

[:3-1] Spinedi, Eduardo; Cardinali, Daniel P. (2019). "Neuroendocrine-Metabolic Dysfunction and Sleep Disturbances in Neurodegenerative Disorders: Focus on Alzheimer's Disease and Melatonin". Neuroendocrinology. 108 (4): 354–364. doi:10.1159/000494889. ISSN 0028-3835.

[2] Spira, Adam P.; Gottesman, Rebecca F. (April 2017). "Sleep disturbance: an emerging opportunity for Alzheimer's disease prevention?". International Psychogeriatrics. 29 (4): 529–531. doi:10.1017/S1041610216002131. ISSN 1041-6102. PMC 5493989. PMID 27938445.

[3] Brown, Belinda M.; Rainey-Smith, Stephanie R.; Villemagne, Victor L.; Weinborn, Michael; Bucks, Romola S.; Sohrabi, Hamid R.; Laws, Simon M.; Taddei, Kevin; Macaulay, S. Lance; Ames, David; Fowler, Christopher (2016-05-01). "The Relationship between Sleep Quality and Brain Amyloid Burden". Sleep. 39 (5): 1063–1068. doi:10.5665/sleep.5756. ISSN 0161-8105. PMC 4835305. PMID 27091528.

[4] Shukla, Mayuri; Govitrapong, Piyarat; Boontem, Parichart; Reiter, Russel J.; Satayavivad, Jutamaad (2017-08-28). "Mechanisms of Melatonin in Alleviating Alzheimer's Disease". Current Neuropharmacology. 15 (7). doi:10.2174/1570159X15666170313123454. PMC 5652010. PMID 28294066.

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