Pokeweed mitogen
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Pokeweed mitogen is a mitogen derived from Phytolacca americana. It functions as a lectin.
Clinical Significance
Pokeweed mitogen has the ability to play a role for the immune system. It can test for immunodeficiency by inducing B-cell proliferation and test for abnormal counts. [1] It can also induce proliferation of cells that target tumors, which is useful for the treatment of cancer. [2]
References
- ^ Bekeredjian-Ding I, Foermer S, Kirschning CJ, Parcina M, Heeg K (2012-01-04). "Poke weed mitogen requires Toll-like receptor ligands for proliferative activity in human and murine B lymphocytes". PLOS ONE. 7 (1): e29806. Bibcode:2012PLoSO...729806B. doi:10.1371/journal.pone.0029806. PMC 3251602. PMID 22238657.
- ^ Numa K, Tani T, Kodama M (1990). "Trial of anticancer immunotherapy with immobilized pokeweed mitogen: immunotherapy by extracorporeal circulation". Cancer Immunology, Immunotherapy. 32 (2): 125–130. doi:10.1007/BF01754209. PMID 2289204. S2CID 26066215.
External links
- Pokeweed+mitogens at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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