User:Powell Cat/Prohormone
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Prohormone
A prohormone is a committed precursor of a hormone, usually having minimal hormonal effect by itself but rather circulating in the blood stream as a hormone in an inactivated form, ready to be activated later by post-translational modification.[1] Examples of natural, human prohormones include proinsulin and pro-opiomelanocortin.
For peptide hormones, the conversion process from prohormone to hormone (pro-protein to protein) typically occurs after being exported to the endoplasmic reticulum and often requires multiple processing enzymes. Proamylin, which is cosecreted with proinsulin, requires the above three factors and an amidating monooxygenase.[2]
Discovery
Applications
Prohormone supplements
Prohormone vs Anabolic Steroid
See also
References
Granados, Jorge; Gillum, Trevor L.; Christmas, Kevin M.; Kuennen, Matthew R. (2014-03-01). "Prohormone supplement 3β-hydroxy-5α-androst-1-en-17-one enhances resistance training gains but impairs user health". Journal of Applied Physiology. 116 (5): 560–569. doi:10.1152/japplphysiol.00616.2013. ISSN 8750-7587
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- ^ Miller, Benjamin Frank (1997). Miller-Keane Encyclopedia & dictionary of medicine, nursing & allied health. Claire Brackman Keane (6th ed.). Philadelphia: Saunders. ISBN 0-7216-6278-1. OCLC 36465055.
- ^ "Amylin Proprotein Processing Generates Progressively More Amyloidogenic Peptides that Initially Sample the Helical State". Biochemistry. 47: 9900–9910. August 19, 2008 – via American Chemical Society.