Talk:COVID-19 drug repurposing research

This is the talk page for discussing improvements to the COVID-19 drug repurposing research article.
This is not a forum for general discussion of the article's subject.

Put new text under old text. Click here to start a new topic.
New to Wikipedia? Welcome! Learn to edit; get help.

Article policies

Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL

Archives: 1, 2: 14 days

The contentious topics procedure applies to this page. This page is related to COVID-19, broadly construed, which has been designated as a contentious topic.

Editors who repeatedly or seriously fail to adhere to the purpose of Wikipedia, any expected standards of behaviour, or any normal editorial process may be blocked or restricted by an administrator. Editors are advised to familiarise themselves with the contentious topics procedures before editing this page.

This article has not yet been rated on Wikipedia's content assessment scale.
It is of interest to multiple WikiProjects.

Please add the quality rating to the {{WikiProject banner shell}} template instead of this project banner. See WP:PIQA for details.

COVID-19 High‑importance

	COVID-19 portal This article is within the scope of WikiProject COVID-19, a project to coordinate efforts to improve all COVID-19-related articles. If you would like to help, you are invited to join and to participate in project discussions.COVID-19Wikipedia:WikiProject COVID-19Template:WikiProject COVID-19COVID-19
High	This article has been rated as High-importance on the project's importance scale.

Please add the quality rating to the {{WikiProject banner shell}} template instead of this project banner. See WP:PIQA for details.

Medicine: Society / Pulmonology Mid‑importance

	Medicine portal This article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.MedicineWikipedia:WikiProject MedicineTemplate:WikiProject Medicinemedicine
Mid	This article has been rated as Mid-importance on the project's importance scale.
	This article is supported by the Society and Medicine task force (assessed as Mid-importance).
	This article is supported by the Pulmonology task force (assessed as Mid-importance).

Please add the quality rating to the {{WikiProject banner shell}} template instead of this project banner. See WP:PIQA for details.

Pharmacology Mid‑importance

	This article is within the scope of WikiProject Pharmacology, a collaborative effort to improve the coverage of Pharmacology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.PharmacologyWikipedia:WikiProject PharmacologyTemplate:WikiProject Pharmacologypharmacology
Mid	This article has been rated as Mid-importance on the project's importance scale.

Please add the quality rating to the {{WikiProject banner shell}} template instead of this project banner. See WP:PIQA for details.

Viruses Mid‑importance

	Viruses portal This article is within the scope of WikiProject Viruses, a collaborative effort to improve the coverage of viruses on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.VirusesWikipedia:WikiProject VirusesTemplate:WikiProject Virusesvirus
Mid	This article has been rated as Mid-importance on the project's importance scale.

Please add the quality rating to the {{WikiProject banner shell}} template instead of this project banner. See WP:PIQA for details.

Disaster management Mid‑importance

	This article is within the scope of WikiProject Disaster management, a collaborative effort to improve the coverage of Disaster management on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.Disaster managementWikipedia:WikiProject Disaster managementTemplate:WikiProject Disaster managementDisaster management
Mid	This article has been rated as Mid-importance on the project's importance scale.

Please add the quality rating to the {{WikiProject banner shell}} template instead of this project banner. See WP:PIQA for details.

International relations Mid‑importance

	This article is within the scope of WikiProject International relations, a collaborative effort to improve the coverage of International relations on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.International relationsWikipedia:WikiProject International relationsTemplate:WikiProject International relationsInternational relations
Mid	This article has been rated as Mid-importance on the project's importance scale.

WikiProject COVID-19 consensus

WikiProject COVID-19 aims to add to and build consensus for pages relating to COVID-19. They have so far discussed items listed below. Please discuss proposed improvements to them at the project talk page.

General

Superseded by TfD October 2020 and later practice - consult regular {{Current}} guidance.

Refrain from using Worldometer (worldometers.info) as a source due to common errors being observed as noted on the Case Count Task Force common errors page. (April 2020, April 2020)

For infoboxes on the main articles of countries, use Wuhan, Hubei, China for the origin parameter. (March 2020)

"Social distancing" is generally preferred over "physical distancing". (April 2020, May 2020)

Page title

COVID-19 (full caps) is preferable in the body of all articles, and in the title of all articles/category pages/etc.(RM April 2020, including the main article itself, RM March 2021).

SARS-CoV-2 (exact capitalisation and punctuation) is the common name of the virus and should be used for the main article's title, as well as in the body of all articles, and in the title of all other articles/category pages/etc. (June 2022, overturning April 2020)

Map

There is no consensus about which color schemes to use, but they should be consistent within articles as much as possible. There is agreement that there should be six levels of shading, plus gray for areas with no instances or no data. (May 2020)

There is no consensus about whether the legend, the date, and other elements should appear in the map image itself. (May 2020)

For map legends, ranges should use fixed round numbers (as opposed to updating dynamically). There is no consensus on what base population to use for per capita maps. (May 2020)

To ensure you are viewing the current list, you may wish to purge this page.

Treatments for COVID-19: Current consensus

A note on WP:MEDRS: Per this Wikipedia policy, we must rely on the highest quality secondary sources and the recommendations of professional organizations and government bodies when determining the scientific consensus about medical treatments.

Ivermectin: The highest quality sources (1 2 3 4) suggest Ivermectin is not an effective treatment for COVID-19. In all likelihood, ivermectin does not reduce all-cause mortality (moderate certainty) or improve quality of life (high certainty) when used to treat COVID-19 in the outpatient setting (4). Recommendations from relevant organizations can be summarized as: Evidence of efficacy for ivermectin is inconclusive. It should not be used outside of clinical trials. (May 2021, June 2021, June 2021, July 2021, July 2021) (WHO, FDA, IDSA, ASHP, CDC, NIH)
Chloroquine & hydroxychloroquine: The highest quality sources (1 2 3 4) demonstrate that neither is effective for treating COVID-19. These analyses accounted for use both alone and in combination with azithromycin. Some data suggest their usage may worsen outcomes. Recommendations from relevant organizations can be summarized: Neither hydroxychloroquine nor chloroquine should be used, either alone or in combination with azithromycin, in inpatient or outpatient settings. (July 2020, Aug 2020, Sep 2020, May 2021) (WHO, FDA, IDSA, ASHP, NIH)
Ivmmeta.com, c19ivermectin.com, c19hcq.com, hcqmeta.com, trialsitenews.com, etc: These sites are not reliable. The authors are pseudonymous. The findings have not been subject to peer review. We must rely on expert opinion, which describes these sites as unreliable. From published criticisms (1 2 3 4 5), it is clear that these analyses violate basic methodological norms which are known to cause spurious or false conclusions. These analyses include studies which have very small sample sizes, widely different dosages of treatment, open-label designs, different incompatible outcome measures, poor-quality control groups, and ad-hoc un-published trials which themselves did not undergo peer-review. (Dec 2020, Jan 2021, Feb 2021)

Which pages use this template?

Last updated (diff) on 27 February 2023 by Sumanuil (t · c)

Humour content

Background: The Ivermectin section of this article contains a humourous tweet from the FDA with the text "You are not a horse. You are not a cow. Seriously, y'all. Stop it." I removed this yesterday, with the edit summary "Rm humorous FDA tweet. The FDA's actual position is in the adjacent text, and the joke is very unbefitting for an encyclopedia article on a medical topic." This was then reverted by User:TrangaBellam with the summary "Disagree."

Wikipedia is intended to present neutral, informative, encyclopedic content, not to make fun of wrong people. Specifically, this article is supposed to explain about COVID-19 drug repurposing research. I have yet to see any possible justification for keeping the joke tweet in the article. --Yair rand (talk) 09:23, 18 November 2021 (UTC)[reply]

In absence of any attempt at justifying its inclusion, I have removed the aforementioned humour content. --Yair rand (talk) 17:24, 19 December 2021 (UTC)[reply]

It's fine. If it's what the FDA are saying then it's due (and of course behind it is the serious point that some people were taking horse paste for COVID, which is ... unwise). Alexbrn (talk) 17:40, 19 December 2021 (UTC)[reply]

Spironolactone

"Scientists offer hope after trials show a combination of spironolactone and dexamethasone work far better than dexamethasone alone" https://www.telegraph.co.uk/news/2021/11/27/spidex-drug-cocktail-could-defeat-new-covid-variant/ 2600:8804:6600:83:89EB:A1DD:FFCA:B3CA (talk) 17:28, 29 November 2021 (UTC)[reply]

Any WP:MEDRS? This seems to be a news story based on a tiny trial in an iffy journal. Alexbrn (talk) 17:30, 29 November 2021 (UTC)[reply]

This study found that zinc supplementation might be helpful

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923946/#s0020title

I am unable to add it to the main article, insufficient perms. If someone can add it to the article, tag me! --Cripplemac (talk) 18:46, 18 December 2021 (UTC)[reply]