Multidrug resistance-associated protein 5 is a protein that in humans is encoded by the ABCC5gene.[5][6][7]
Function
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.[7]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
Kool M, de Haas M, Scheffer GL, Scheper RJ, van Eijk MJ, Juijn JA, Baas F, Borst P (Aug 1997). "Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines". Cancer Research. 57 (16): 3537–47. PMID9270026.
Suzuki T, Nishio K, Sasaki H, Kurokawa H, Saito-Ohara F, Ikeuchi T, Tanabe S, Terada M, Saijo N (Sep 1997). "cDNA cloning of a short type of multidrug resistance protein homologue, SMRP, from a human lung cancer cell line". Biochemical and Biophysical Research Communications. 238 (3): 790–4. doi:10.1006/bbrc.1997.7346. PMID9325169.
Suzuki T, Sasaki H, Kuh HJ, Agui M, Tatsumi Y, Tanabe S, Terada M, Saijo N, Nishio K (Jan 2000). "Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts". Gene. 242 (1–2): 167–73. doi:10.1016/S0378-1119(99)00529-6. PMID10721709.
Alcorn J, Lu X, Moscow JA, McNamara PJ (Nov 2002). "Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction". The Journal of Pharmacology and Experimental Therapeutics. 303 (2): 487–96. doi:10.1124/jpet.102.038315. PMID12388627. S2CID16195525.
Pascolo L, Fernetti C, Pirulli D, Crovella S, Amoroso A, Tiribelli C (Mar 2003). "Effects of maturation on RNA transcription and protein expression of four MRP genes in human placenta and in BeWo cells". Biochemical and Biophysical Research Communications. 303 (1): 259–65. doi:10.1016/S0006-291X(03)00327-9. PMID12646196.
Reid G, Wielinga P, Zelcer N, De Haas M, Van Deemter L, Wijnholds J, Balzarini J, Borst P (May 2003). "Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5". Molecular Pharmacology. 63 (5): 1094–103. doi:10.1124/mol.63.5.1094. PMID12695538. S2CID7444400.
