The United States Senate election of 1972 in Massachusetts was held on November 7, 1972. Incumbent Republican Senator Edward Brooke defeated Democratic nominee John Droney in a landslide. As of 2022[update], this remains the last time that a Republican has Massachusetts’s Class 2 Senate seat and the last time a Republican has been elected to either Senate seat for a full term. This was also the last time until 2010 that a Republican would win any U.S. Senate election in the state.