Talk:Morphine

This is the talk page for discussing improvements to the Morphine article.
This is not a forum for general discussion of the article's subject.

Put new text under old text. Click here to start a new topic.
New to Wikipedia? Welcome! Learn to edit; get help.

Article policies

Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL

Archives: 1, 2: 2 months

Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Morphine.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

Template:Vital article

This article has not yet been rated on Wikipedia's content assessment scale.
It is of interest to multiple WikiProjects.

Template:WP1.0

Please add the quality rating to the {{WikiProject banner shell}} template instead of this project banner. See WP:PIQA for details.

Pharmacology B‑class High‑importance

	This article is within the scope of WikiProject Pharmacology, a collaborative effort to improve the coverage of Pharmacology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.PharmacologyWikipedia:WikiProject PharmacologyTemplate:WikiProject Pharmacologypharmacology articles
B	This article has been rated as B-class on Wikipedia's content assessment scale.
High	This article has been rated as High-importance on the project's importance scale.

Please add the quality rating to the {{WikiProject banner shell}} template instead of this project banner. See WP:PIQA for details.

Chemicals: Core B‑class Mid‑importance

	This article is within the scope of WikiProject Chemicals, a daughter project of WikiProject Chemistry, which aims to improve Wikipedia's coverage of chemicals. To participate, help improve this article or visit the project page for details on the project.ChemicalsWikipedia:WikiProject ChemicalsTemplate:WikiProject Chemicalschemicals articles
B	This article has been rated as B-class on Wikipedia's content assessment scale.
Mid	This article has been rated as Mid-importance on the project's importance scale.
	This is a core article in the WikiProject Chemicals worklist.

Please add the quality rating to the {{WikiProject banner shell}} template instead of this project banner. See WP:PIQA for details.

Medicine: Translation B‑class Mid‑importance

	Medicine portal This article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.MedicineWikipedia:WikiProject MedicineTemplate:WikiProject Medicinemedicine articles
B	This article has been rated as B-class on Wikipedia's content assessment scale.
Mid	This article has been rated as Mid-importance on the project's importance scale.
	This article is supported by the Translation task force (assessed as High-importance).
	This article was selected on the Medicine portal as one of Wikipedia's best articles related to Medicine.

Psychoactive and Recreational Drugs (defunct)

This article is within the scope of WikiProject Psychoactive and Recreational Drugs, a project which is currently considered to be defunct.Psychoactive and Recreational DrugsWikipedia:WikiProject Psychoactive and Recreational DrugsTemplate:WikiProject Psychoactive and Recreational DrugsPsychoactive and Recreational Drugs articles

Fatal dose

" One poor quality study on morphine overdoses among soldiers reported that the fatal dose was 0.78 mcg/ml in males (~71 mg for an average 90 kg adult man) and 0.98mcg/ml in females (~74 mg for an average 75 kg female). It was not specified whether the dose was oral, parenteral or IV "

Surely it does not matter whether the dose was oral or IV if this is referring to final blood concentration? If oral bioavailability is about 1/3 then the fatal dose would be about 225mg orally would it not? (though this seems rather low) Of course one would then also have to consider the timescale over which the dose was taken etc — Preceding unsigned comment added by 82.26.113.110 (talk) 18:43, 6 March 2021 (UTC)[reply]

Need for expert attention

@Doc James: I would recommend you find a good chemist to look at the chemistry section of the Morphine article. I moved the chemical synthesis out, because that description is okay (better, were it based on reviews, but at least it is sourced). But the real issue is that the chemistry section—which reads as naive—is, moreover, completely unsourced. (I removed the only two prior citations, one to a high school web page, and the other to a college class handout, as inapproproate for such an important substance with such a rich literature.) Were I a logging editor, I would have taken the whole thing out, as suspected plagiarism, and on the basis of its misstatements (so rampant it is with vagaries and inaccuracies). Instead, I "hid" 2-3 glaring examples (not even the most glaring), and indicated the problem with a section tag. [ a former prof.] 2601:246:C700:19D:E50A:9B38:6680:3C78 (talk) 20:59, 7 February 2020 (UTC)[reply]

Feel free to keep working on it :-) Not really my area of interest. If you see stuff that is unreferenced and incorrect feel free to remove it. Doc James (talk · contribs · email) 00:30, 8 February 2020 (UTC)[reply]

Minor nomenclature issue

The stereochemical descriptions of the intermediate enantiomers in the biosynthesis sections are presented in two different styles. I leave it to the experts to decide between the two styles (with or without parens/italics), and propagate just one for the sake of student readers. Also, the PD table mentions the dextro- and levo- forms alongside "Morphine", which here, alongside the two, implies what... activity data on the racemate? (I am not sure I believe this, but it is possible that such was formulated.) I would clarify this, and recommend 2-3 other sourced sentences, placed appropriately throughout, including in the lead, making clear the stereochemical form of what most know as morphine, the poppy- and human-derived molecule. Merci. 2601:246:C700:19D:E50A:9B38:6680:3C78 (talk) 21:07, 7 February 2020 (UTC)[reply]

Metadon

Vem har någon erfarenhet av Levopidon? Morfius1976 (talk) 10:55, 14 February 2021 (UTC)[reply]

More addictive than...

So the, history part has a sentence "Later it was found that morphine was more addictive than either alcohol or opium".

But not sure if this is true, or what it even means. Isn't the main ingredient of opium morphine, which should make it exactly as addictive, if not more (if the other compounds have additive effects)? Also, alcohols are extremely addictive, so without a references I find it hard to believe that morphine can be more addictive, although maybe I am wrong. Is there any reference for this? 84.248.117.35 (talk) 16:35, 24 March 2022 (UTC)[reply]