Chromosome 11 open reading frame 53 is a protein that in humans is encoded by the C11orf53 gene.[5] Reduction in C11orf53 gene expression is associated with increased odds of occurrence of colorectal cancer.[6] Specifically sequence variation (rs3802842) close to the C11orf53 gene locus that lowers the expression of C11orf53 has been observed in the colonic mucosal cells immediately adjacent to colon cancer tumors.[7][8] C11orf53 downregulation aids in cells' ability to survive in acidic conditions, which are typical of the tumor microenvironment.[9] CRISPR-Cas9 inactivation of C11orf53 in an acute myeloid leukemia cell line made the cells resistant to the BCL2inhibitorVenetoclax, further supporting a role in cancer predisposition.[10][11]
^Delgado AP, Brandao P, Chapado MJ, Hamid S, Narayanan R (July 2014). "Open reading frames associated with cancer in the dark matter of the human genome". Cancer Genomics & Proteomics. 11 (4): 201–213. PMID25048349.
^Funato Y, Yoshida A, Hirata Y, Hashizume O, Yamazaki D, Miki H (November 2020). "The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis". Developmental Cell. 55 (4): 387–397.e8. doi:10.1016/j.devcel.2020.08.009. PMID32918875. S2CID221643438.
