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Janeway lesion

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Janeway lesions are non-tender, small erythematous or haemorrhagic macules or nodules in the palms or soles, which are pathognomonic of infective endocarditis. The pathology is due to a type III hypersensitivity reaction.

They are named after Theodore Caldwell Janeway (1872–1917), a professor of medicine with interests in cardiology and infectious disease.

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These lesions were named after Edward Gamaliel Janeway, M.D. by his pupil Emanuel Libman, M.D. in a paper he published in 1906 - as cited by Prutkin JM and Fye WB in their Profiles in Cardiology article in Clinical Cardiology volume 29, 376-377, 2006.

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