User:Jordynlazic/Antifungal
Of the clinically employed azole antifungals, only a handful are used systemically.These include ketoconazole, itraconazole, fluconazole, fosfluconazole, voriconazole, posaconazole, and isavuconazole. Examples of non-azole systemic antifungals include griseofulvin and terbinafine.[1]
Azole Antifungals
Azole antifungals inhibit conversion of lanosterol to ergosterol by inhibition of lanosterol 14α-demethylase. These compounds have a five-membered ring containing two or three nitrogen atoms[1]. The imidazole antifungals contain a 1,3-diazole (imidazole) ring (two nitrogen atoms), whereas the triazole antifungals have a ring with three nitrogen atoms.[2][1]
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References
- ^ a b c Dixon, Dennis M.; Walsh, Thomas J. (1996), Baron, Samuel (ed.), "Antifungal Agents", Medical Microbiology (4th ed.), Galveston (TX): University of Texas Medical Branch at Galveston, ISBN 978-0-9631172-1-2, PMID 21413319, retrieved 2022-12-02
- ^ PubChem. "Imidazole". pubchem.ncbi.nlm.nih.gov. Retrieved 2022-12-02.