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Darryl B. Hood

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Lead

Darryl B. Hood is known for being an environmental neuroscientist at Ohio State University and the author of Multigenerational Effects of Inhaled B(a)P on Development. Hood led the most successful Minority S11 NIEHS-sponsored initiative, known as Advanced Research Cooperation in Environmental Health (ARCH) Program. He has also done work included in several articles on recalibrating reference concentrations for inhaled B(a)P exposures in reproductive and neurotoxicity. [1] As a co-architect, Darryl B. Hood has continued to work at Ohio State University on the Public Health Exposome.[2]

Education

Darryl B. Hood graduated with a bachelor science degree in biology and chemistry from Johnson C. Smith University and received his Ph.D. from East Tennessee State University in 1990. Hood completed his postdoctoral studies at Vanderbilt University School of Medicine at the Center in Molecular Toxicology.[1]

Research

Darryl B. Hood has been a part of 93 publications, ranging from an ExWAS approach to Latino cancer disparities to polycyclic aromatic hydrocarbons and their implications for developmental, molecular, and behavioral neurotoxicology[3]

Neurotoxicology

Darryl B. Hood's work in the research of polycyclic aromatic hydrocarbons, as well as benzo(a)pyrene, has shown that utero exposure to B9a)P results in a diminished expression of specific NMDA receptor subunits that manifest their effects later in life, being shown as deficits in neuronal activity in the offspring. Hood and his fellow researchers' work and testing led to the conclusion that exposure to B(a)P in utero at the time of synapse formation will express a strong negative effect on brain function and will produce defects in activity and experience-dependent gene expression, leading to lower mental developmental index scores and intelligence quotients.[4]

Behavioral

Darryl B. Hood has contributed to the field of behavioral neuroscience through his research on the effects that benzo(a)pyrene has had on glutamatergic signaling, thus affecting behavioral processes.[5]

In the article "Prenatal Exposure to Benzo(a)pyrene Impairs Later-Life Cortical Neuronal Function", Hood discusses the expression of glutamate receptor subunits and the role that this plays in cortical responses. Along with his fellow researchers, Hood discovered that exposure to B(a)P throughout development can impact cortical function through modulation of glutamatergic receptor subunit expression within the somatosensory cortex. In order to evaluate this, Hood studied how mRNA is expressed in both a control group and a group exposed to B(a)P for NR2B, which is a glutamatergic NMDA receptor subunit.[6]

In the article "PAH Particles Perturb Prenatal Processes and Phenotypes: Protection from Deficits in Object Discrimination Afforded by Dampening of Brain Oxidoreductase Following In Utero Exposure to Inhaled Benzo(a)pyrene", Hood used the wild-type (WT) cytochrome P450 oxidoreductase (Cpr) mouse to evaluate glutamatergic signaling and NMDA receptor function. He successfully demonstrated that the harm done by exposure to B(a)P in early cortical development results in lasting phenotypic changes in Cpr mouse models. In the medial prefrontal cortex (mPFC), there was a statistically significant increase in basal level concentrations of glutamate for the B(a)P-exposed Cpr mice. The results of this data coincides with previous results suggesting an impact on currents coming inward through the NMDA receptor when glutamate levels are elevated.[7]

Comparative Developmental Biology

Darryl B. Hood's work has shown harmful effects of benzo(a)pyrene regarding glutamatergic signaling regulation.[1] His work gave new profound information to the field of Environmental Health sciences about postal brain development in the environment.[8]

Environmental

Darryl B. Hood also took part in many environmental and socially-based studies, such as The Effects of Social, Personal, and Behavioral Risk Factors and PM2.% on Cardio-Metabolic Disparities in a Cohort of Community Health Center Patients. The results of this experiment indicated that race, as a risk factor for disease, and as a way to elaborate on the patterning of CMD, should not be considered as "biological programming". The study indefinitely connected the disparities amongst highly impoverished areas to be an important factor in regard to health outcomes. The publication called for additional studies that examine racial health disparities within different SES, social-economic status, and subgroups, particularly with these groups being in different geographical areas.[9]

Concluding Remarks

The Associate Professor teaches many things and has accomplished many years of experience. He completed a 4-year postdoc, conducted research, and much more. He focuses primarily on his NIH-funded study. [10] Neurotoxicology is one of his main focuses, emphasizing environmental public health. Dr. Darryl B Hood also serves on the scholar's direct board.[11] This journal is a fast-track option to ensure your journal gets available within three weeks online.

Article body

References

  1. ^ a b c "Darryl B. Hood, PhD". College of Public Health | The Ohio State University. Retrieved 2023-02-02.
  2. ^ "Dr. Darryl B., Ph.D., Hood". cura.osu.edu. Retrieved 2023-02-12.
  3. ^ "Darryl B. Hood".
  4. ^ Hood, Darryl B.; Ramesh, Aramandla; Chirwa, Sanika; Khoshbouei, Habibeh; Archibong, Anthony E. (2011-01-01), Gupta, Ramesh C. (ed.), "Chapter 44 - Developmental toxicity of polycyclic aromatic hydrocarbons", Reproductive and Developmental Toxicology, San Diego: Academic Press, pp. 593–606, doi:10.1016/b978-0-12-382032-7.10044-x, ISBN 978-0-12-382032-7, retrieved 2023-04-02
  5. ^ "Darryl B. Hood". ResearchGate. April 18, 2023.
  6. ^ McCallister, Monique M.; Maguire, Mark; Ramesh, Aramandla; Aimin, Qiao; Liu, Sheng; Khoshbouei, Habibeh; Aschner, Michael; Ebner, Ford F.; Hood, Darryl B. (2008-09). "Prenatal exposure to benzo(a)pyrene impairs later-life cortical neuronal function". NeuroToxicology. 29 (5): 846–854. doi:10.1016/j.neuro.2008.07.008. PMC 2752856. PMID 18761371. {{cite journal}}: Check date values in: |date= (help)CS1 maint: PMC format (link)
  7. ^ "PAH particles perturb prenatal processes and phenotypes: protection from deficits in object discrimination afforded by dampening of brain oxidoreductase following in utero exposure to inhaled benzo(a)pyrene". academic.oup.com. Oxford University Press. October 10, 2011. doi:10.1093/toxsci/kfr261. PMC 3243744. PMID 21987461. Retrieved 2023-04-19. {{cite web}}: Unknown parameter |authors= ignored (help)CS1 maint: PMC format (link)
  8. ^ "Darryl Hood | Environmental Sciences Graduate Program". esgp.osu.edu. Retrieved 2023-03-03.
  9. ^ Juarez, Paul D.; Tabatabai, Mohammad; Burciaga Valdez, Robert; Hood, Darryl B.; Im, Wansoo; Mouton, Charles; Colen, Cynthia; Al-Hamdan, Mohammad Z.; Matthews-Juarez, Patricia; Lichtveld, Maureen Y.; Sarpong, Daniel; Ramesh, Aramandla; Langston, Michael A.; Rogers, Gary L.; Phillips, Charles A. (2020-05-19). "The Effects of Social, Personal, and Behavioral Risk Factors and PM2.5 on Cardio-Metabolic Disparities in a Cohort of Community Health Center Patients". International Journal of Environmental Research and Public Health. 17 (10): 3561. doi:10.3390/ijerph17103561. ISSN 1660-4601. PMC 7277630. PMID 32438697.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link)
  10. ^ "Ohio Innovation Exchange, Darryl B. Hood". people.ohioinnovationexchange.org. Retrieved 2023-02-27.
  11. ^ "Scholars Direct Journal". scholars.direct. Retrieved 2023-02-27.
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