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Kat Holt

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Kat Holt
Born
Kathryn Elizabeth Holt
NationalityAustralian
Alma materUniversity of Western Australia (BSc (Hons), BA)
University of Cambridge (PhD)
University of Melbourne (MEpi)
Scientific career
FieldsMicrobial genomics
Computational genomics
Epidemiology
InstitutionsMonash University
London School of Hygiene & Tropical Medicine
ThesisHigh-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi (2008)
Doctoral advisorGordon Dougan
Julian Parkhill
Duncan Maskell
Websitehttps://holtlab.net

Kathryn "Kat" Elizabeth Holt is an Australian computational biologist specializing in infectious disease genomics. She is a professor at Monash University's Department of Infectious Diseases and a professor of Microbial Systems Genomics at the London School of Hygiene & Tropical Medicine (LSHTM). Her current research focuses on investigating the evolution and dissemination of antimicrobial resistance. In 2015, Holt received the L'Oréal-UNESCO International Rising Talent Award.

Early life and education

The daughter of two biomedical scientists, Holt grew up in an environment where science was a frequent topic of discussion.[1]

From 2002 to 2005, she was a research assistant at the Telethon Institute for Child Health Research.[2] In 2004, Holt graduated from the University of Western Australia with Bachelor of Science and Bachelor of Arts degrees in Biochemistry, Applied Statistics, and Philosophy, as well as Honours in Genetics with a focus on plant gene expression.[1]

One year after completing her undergraduate education, in 2005, Holt worked as a research technician in the Bioinformatics Division of the Walter and Eliza Hall Institute of Medical Research (WEHI).[2] Shortly afterward, she began her pursuit of a PhD in Molecular Biology from the Wellcome Sanger Trust Institute (WSTI) and the University of Cambridge. Her doctoral research focusing on the genomics of typhoid fever was supervised by Gordan Dougan, Julian Parkhill, and Duncan Maskell. Holt continued her education at the University of Melbourne, where she obtained her Master of Epidemiology degree in 2011.

Career and research

Holt conducted postdoctoral research as a research fellow at the University of Melbourne Department of Microbiology and Immunology from 2010 to 2012. She then became a senior research fellow at the same university in the Department of Biochemistry and Molecular Biology and the Bio21 Institute from 2012 to 2018. In 2015, Holt was named a L'Oréal-UNESCO International Rising Talent.

In April 2018, Holt was appointed a professor of Microbial Systems Genomics at the London School of Hygiene & Tropical Medicine (LSHTM) in the Department of Pathogen Molecular Biology. Additionally, Holt has been a professor of research at Monash University in the Department of Infectious Diseases since January 2019.

Publications

  • Heaton, T., Rowe, J., Turner, S., Aalberse, R.C., de Klerk, D., Suriyaarachchi, D., Serralha, M., Holt, B.J., Hollams, E., Yerkovich, S., Holt, K., Sly, P.D., Goldblatt, J., Le Souef, P. & Holt, P.G. (2005). An immunoepidemiological approach to asthma: identification of in vitro T-cell response patterns associated with different wheezing phenotypes amongst 11 year olds. The Lancet, 365(9454):142-149. doi:10.1016/S0140-6736(05)17704-6
  • Holt, K.E., Thomson, N.R., Wain, J., Langridge, G., Hasan, R., Bhutta, Z.A., Quail, M.A., Norbertczak, H., Walker, D., Simmonds, M., White, B., Bason, N., Mungall K., Dougan, G. & Parkhill, J. (2009). Pseudogene accumulation in the evolutionary histories of Salmonella enterica serovars Paratyphi A and Typhi. BMC Genomics, 10:36. doi:10.1186/1471-2164-10-36
  • Rohde, H., Qin, J., Cui, Y., Li, D., Loman, N.J., Hentschke, M., Chen, W., Pu, F., Peng, Y., Li, J., Xi, F., Li, S., Li, Y., Zhang, Z., Yang, X., Zhao, M., Wang, P., Guan, Y., Cen, Z., Zhao, X., Christner, M., Kobbe, R., Loos, S., Oh, J., Yang, L., Danchin, A., Gao, G.F., Song, Y., Li, Y., Yang, H., Wang, J., Xu, J., Pallen, M.J., Wang, J., Aepfelbacher, M., Yang, R., E. coli O104:H4 Genome Analysis Crowd-Sourcing Consortium (Holt, K.E., Studholme, D.J., Feldgarden, M., Manrique, M.) (2011). Open-source genomic analysis of Shiga-toxin-producing E. coli O104:H4. The New England Journal of Medicine, 365(8):718-724. doi:10.1056/NEJMoa1107643
  • Holt, K.E., Baker, S., Weill, F.X., Holmes, E.C., Kitchen, A., Yu, J., Sangal, V., Brown, D.J., Coia, J.E., Kim, D.W., Choi S.Y., Kim, S.H., da Silveira, W.D., Pickard, D.J., Farrar, J.J., Parkhill, J., Dougan, G. & Thomson, N.R. (2012). Shigella sonnei genome sequencing and phylogenetic analysis indicate recent global dissemination from Europe. Nature Genetics, 44(9):1056-1059. doi:10.1038/ng.2369

Awards and recognitions

References

  1. ^ a b "Tracking the spread of deadly diseases". Stories of Australian Science. 1 October 2013. Retrieved 6 September 2019.{{cite web}}: CS1 maint: url-status (link)
  2. ^ a b c "Kathryn Holt, Bio21 Institute, The University of Melbourne". L'Oréal For Women in Science Australia & New Zealand. 1 September 2013. Retrieved 7 September 2019.{{cite web}}: CS1 maint: url-status (link)
  3. ^ "2015 For Women in Science International Rising Talents". UNESCO. Retrieved 6 September 2019.{{cite web}}: CS1 maint: url-status (link)
  4. ^ "Georgina Sweet Laureate Fellowship". University of Melbourne. 15 January 2019. Retrieved 6 September 2019.{{cite web}}: CS1 maint: url-status (link)
  5. ^ "Gottschalk Medal". Australian Academy of Science. Retrieved 6 September 2019.{{cite web}}: CS1 maint: url-status (link)
  6. ^ "Senior Medical Research Fellowship". The Viertel Charitable Foundation. Retrieved 6 September 2019.{{cite web}}: CS1 maint: url-status (link)
  7. ^ "Philanthropies Select 41 Scientists as International Research Scholars". Howard Hughes Medical Institute. Retrieved 6 September 2019.{{cite web}}: CS1 maint: url-status (link)

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