UTY (gene)

UTY
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3ZLI, 3ZPO, 4UF0, 5FY0, 5FXW, 5FXX, 5FXZ, 5FY1, 5FY7, 5FYM, 5FXV, 5A1L
Identifiers
Aliases	UTY, KDM6AL, UTY1, ubiquitously transcribed tetratricopeptide repeat containing, Y-linked, KDM6C
External IDs	OMIM: 400009; GeneCards: UTY; OMA:UTY - orthologs
Gene location (Human)
Chr.	Y chromosome (human)
End	13,480,673 bp
RNA expression pattern
	Top expressed in
	gonad; ; corpus callosum; ; testicle; ; tendon of biceps brachii; ; rectum; ; right lung; ; prostate; ; cartilage tissue; ; corpus epididymis; ; middle frontal gyrus;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; dioxygenase activity; histone H3-tri/di-methyl-lysine-27 demethylase activity; metal ion binding; histone demethylase activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; chromatin binding; chromatin DNA binding; sequence-specific DNA binding;
Cellular component	nucleus; nucleoplasm; MLL3/4 complex;
Biological process	regulation of gene expression; histone H3-K27 demethylation; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	7404
	n/a
	ENSG00000183878
	n/a
	O14607
	n/a
NM_001258249; NM_001258250; NM_001258251; NM_001258252; NM_001258253;
	NM_001258254; NM_001258255; NM_001258256; NM_001258257; NM_001258258; NM_001258259; NM_001258260; NM_001258261; NM_001258262; NM_001258263; NM_001258264; NM_001258265; NM_001258266; NM_001258267; NM_001258268; NM_001258269; NM_001258270; NM_007125; NM_182659; NM_182660; NM_001400170; NM_001400171; NM_001400173; NM_001400175; NM_001400177; NM_001400178; NM_001400181; NM_001400183; NM_001400185; NM_001400187; NM_001400189; NM_001400192; NM_001400195; NM_001400199
	n/a
NP_001245178; NP_001245179; NP_001245180; NP_001245181; NP_001245182;
	NP_001245183; NP_001245184; NP_001245185; NP_001245186; NP_001245187; NP_001245188; NP_001245189; NP_001245190; NP_001245191; NP_001245192; NP_001245193; NP_001245194; NP_001245195; NP_001245196; NP_001245197; NP_001245198; NP_001245199; NP_009056; NP_872600; NP_872601; NP_001245196.1; NP_001245192.1; NP_001245178.1; NP_001245194.1; NP_001245186.1; NP_001245191.1; NP_001245187.1
	n/a
	Wikidata
View/Edit Human

Histone demethylase UTY is an enzyme that in humans is encoded by the UTY gene.^[3]^[4]^[5]

This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein–protein interactions. This protein is a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. Alternative splicing results in multiple transcript variants encoding different isoforms.^[5]

Interactions

UTY has been shown to interact with TLE1^[6] and WDR90.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183878 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Greenfield A, Scott D, Pennisi D, Ehrmann I, Ellis P, Cooper L, et al. (December 1996). "An H-YDb epitope is encoded by a novel mouse Y chromosome gene". Nature Genetics. 14 (4): 474–8. doi:10.1038/ng1296-474. PMID 8944031. S2CID 9994966.
^ Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, et al. (April 1998). "The UTX gene escapes X inactivation in mice and humans". Human Molecular Genetics. 7 (4): 737–42. doi:10.1093/hmg/7.4.737. PMID 9499428.
^ ^a ^b "Entrez Gene: UTY ubiquitously transcribed tetratricopeptide repeat gene, Y-linked".
^ Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S (January 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". The Biochemical Journal. 337 ( Pt 1) (1): 13–7. doi:10.1042/0264-6021:3370013. PMC 1219929. PMID 9854018.
^ "STRING: functional protein association networks". string-db.org. Retrieved 2015-05-07.

Lahn BT, Page DC (October 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID 9381176.
Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S (January 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". The Biochemical Journal. 337 ( Pt 1) (1): 13–7. doi:10.1042/0264-6021:3370013. PMC 1219929. PMID 9854018.
Warren EH, Gavin MA, Simpson E, Chandler P, Page DC, Disteche C, et al. (March 2000). "The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen". Journal of Immunology. 164 (5): 2807–14. doi:10.4049/jimmunol.164.5.2807. PMID 10679124.
Foresta C, Ferlin A, Moro E (May 2000). "Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility". Human Molecular Genetics. 9 (8): 1161–9. doi:10.1093/hmg/9.8.1161. PMID 10767340.
Shen P, Wang F, Underhill PA, Franco C, Yang WH, Roxas A, et al. (June 2000). "Population genetic implications from sequence variation in four Y chromosome genes". Proceedings of the National Academy of Sciences of the United States of America. 97 (13): 7354–9. Bibcode:2000PNAS...97.7354S. doi:10.1073/pnas.97.13.7354. PMC 16549. PMID 10861003.
Vogt MH, Goulmy E, Kloosterboer FM, Blokland E, de Paus RA, Willemze R, Falkenburg JH (November 2000). "UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition". Blood. 96 (9): 3126–32. doi:10.1182/blood.V96.9.3126. PMID 11049993.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Agate RJ, Choe M, Arnold AP (February 2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Molecular Biology and Evolution. 21 (2): 384–96. doi:10.1093/molbev/msh027. PMID 14660691.
Gerrard DT, Filatov DA (June 2005). "Positive and negative selection on mammalian Y chromosomes". Molecular Biology and Evolution. 22 (6): 1423–32. doi:10.1093/molbev/msi128. PMID 15758204.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183878 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8944031-3] Greenfield A, Scott D, Pennisi D, Ehrmann I, Ellis P, Cooper L, et al. (December 1996). "An H-YDb epitope is encoded by a novel mouse Y chromosome gene". Nature Genetics. 14 (4): 474–8. doi:10.1038/ng1296-474. PMID 8944031. S2CID 9994966.

[pmid9499428-4] Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, et al. (April 1998). "The UTX gene escapes X inactivation in mice and humans". Human Molecular Genetics. 7 (4): 737–42. doi:10.1093/hmg/7.4.737. PMID 9499428.

[entrez-5] "Entrez Gene: UTY ubiquitously transcribed tetratricopeptide repeat gene, Y-linked".

[pmid9854018-6] Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S (January 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". The Biochemical Journal. 337 ( Pt 1) (1): 13–7. doi:10.1042/0264-6021:3370013. PMC 1219929. PMID 9854018.

[7] "STRING: functional protein association networks". string-db.org. Retrieved 2015-05-07.

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Interactions

References

Further reading