Talk:Pernicious anemia

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April edits

I added some info about PA in a nice edit. Left to add is the relationship between PA and atrophic gastritis...

Understandable?

Do you current editors think this article is understandable? I stated in a previous entry that readers can look up the words they do not know, but is that fair enough? I'm just trying to keep this as legit, helpful, and understandable as possible for everyone. Thanks! OnFire4Jesus (talk) 03:17, 23 March 2008 (EST)

NEUROLOGICAL manifestations:

Neurological manifestations of B12 deficiency include:

Dementia,

Posterlateral sclerosis of the spinal cord,

peripheral neuropathy,

anosmia, and

optic nerve disease.

Pernicious anemia most usually presents via neurological symptoms in societies where food is fortified with folic acid (because folate-fortified foods obscure the better known megaloblastic anemia seen in red blood cells when inadequate B12 is accompanied by inadequate folate.

Epidemiology - self-contradiction

In leading section "Pernicious anemia due to autoimmune problems occurs in about one per 1000 people in the US. Among those over the age of 60, about 2% have the condition.". In Epidemiology section "PA is estimated to affect 0.1% of the general population and 1.9% of those over 60". Both statements have different citations, which support the figures given. BUT in US according to a quick Google search, ~16.8% of population is over 65 (so more than that must be over 60). 1.9% of 16.8% is 0.019 x 0.168 = 0.0032. So even if no-one under 65 has the condition, there should be over 3 per 1000 people with PA. I have no idea whether the correct figure is ~1 per 1000, or >3 per 1000, but they can't both be right.Newburyjohn (talk) 07:42, 31 May 2023 (UTC)[reply]