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Rhodiola rosea

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Rhodiola rosea
Scientific classification Edit this classification
Kingdom: Plantae
Clade: Tracheophytes
Clade: Angiosperms
Clade: Eudicots
Order: Saxifragales
Family: Crassulaceae
Genus: Rhodiola
Species:
R. rosea
Binomial name
Rhodiola rosea
Synonyms[1]
  • Rhodiola roanensis (Britton) Britton
  • Sedum rhodiola DC.
  • S. roanense Britton
  • S. rosea (L.) Scop.
  • S. rosea var. roanense (Britton) A. Berger

Rhodiola rosea (commonly golden root, rose root, roseroot,[2]: 138  Aaron's rod, Arctic root, king's crown, lignum rhodium, orpin rose) is a perennial flowering plant in the family Crassulaceae.[3] It grows naturally in wild Arctic regions of Europe (including Britain), Asia, and North America ( N.B., Nfld. and Labrador, N.S., QC.; Alaska, Maine, N.Y., N.C., Pa., Vt),[4] and can be propagated as a groundcover.[3]

Rhodiola rosea has been used in traditional medicine, and there some high-quality evidence to support its effects.[5][6][7] The United States Food and Drug Administration has issued several warnings to manufacturers of R. rosea dietary supplements for making false health claims about its safety and efficacy.[8][9][10] However, the European Medicines Agency and Committee On Herbal Medicinal Products deemed extracts from R. rosea roots and rhizomes to be well-tolerated, safe, and possibly effective for traditional uses.[11]

The plant is threatened in many countries due to rapidly growing demand.[12] Supply comes mostly from wild harvesting on an industrial scale, and a combination of growing scarcity and a lack of regulation has led to environmental degradation, substitution or adulteration in the market, and illegal harvesting in protected areas.[13]

Description

Rhodiola rosea is from 5 to 40 centimetres (2.0 to 15.7 in) tall, fleshy, and has several stems growing from a short, scaly rootstock. Flowers have 4 sepals and 4 petals, yellow to greenish yellow in color sometimes tipped with red, about 1 to 3.5 millimetres (0.039 to 0.138 in) long, and blooming in summer. Several shoots growing from the same thick root may reach 5 to 35 centimetres (2.0 to 13.8 in) in height. R. rosea is dioecious – having separate female and male plants.[14]

Rhodiola rosea in flower during the spring in the UK
Rhodiola rosea sprouting new growth
Wild Rhodiola rosea plant
Dried R. rosea root

Taxonomy

Rhodiola rosea was first described by Pedanius Dioscorides in De Materia Medica.[15] Many North American plants formerly included in R. rosea are now treated separately as Rhodiola integrifolia and Rhodiola rhodantha.[4]

Chemical constituents

About 140 chemical compounds are in the subterranean portions of R. rosea.[16] Rhodiola roots contain phenols, rosavin, rosin, rosarin, organic acids, terpenoids, phenolic acids and their derivatives, flavonoids, anthraquinones, alkaloids, tyrosol, and salidroside.[17][18]

The chemical composition of the essential oil from R. rosea root growing in different countries varies. For example, rosavin, rosarin, and rosin at their highest concentration according to many tests can be found only in R. rosea of Russian origin; the main components of the essential oil from Rhodiola growing in Bulgaria are geraniol and myrtenol; in China the main components are geraniol and 1-octanol; and in India the main component is phenethyl alcohol. Cinnamyl alcohol was discovered only in the sample from Bulgaria.

Rosavin, rosarin, and salidroside (and sometimes p-tyrosol, rhodioniside, rhodiolin, and rosiridin) are among suspected active ingredients of R. rosea, these compounds are mostly polyphenols.[19] Although these phytochemicals are typically mentioned as specific to Rhodiola rosea extracts, rosea and other Rhodiola species contain many other constituent polyphenols, including proanthocyanidins, quercetin, gallic acid, chlorogenic acid and kaempferol.[20]

Distribution

Rhodiola rosea grows in cold regions of the world, including much of the Arctic, the mountains of Central Asia, scattered in eastern North America and mountainous parts of Europe.[3][21] It grows on sea cliffs and on mountains[2] at high altitude.[3]

Uses

Culinary use

The leaves and shoots are eaten raw, having a bitter flavor, or cooked like spinach, and are sometimes added to salads.[3][22] An extract is sometimes added as a flavoring in vodkas.[23]

Research and regulation

Through 2019, human studies evaluating R. rosea did not have sufficient quality to determine whether it has properties affecting cancer.[15][21][24] Antioxidant and anxiolytic properties have been well documented in many clinical studies.[25][26][27]

A 2014 report by the European Medicines Agency on literature concerning the dried extract of R. rosea stated that "The HMPC conclusions on the use of arctic root medicines are based on their 'traditional use'. This means that, although there is insufficient evidence from clinical trials, the effectiveness of these herbal medicines is plausible and there is evidence that they have been used safely in this way for at least 30 years (including at least 15 years within the EU). Moreover, the intended use does not require medical supervision.".[28]

Protection and management

Rhodiola rosea has not been assessed on the IUCN red list,[29] but is listed on the CITES (Convention on International Trade in Endangered Species of Wild Fauna and Flora) Appendix II which "includes species not necessarily threatened with extinction, but in which trade must be controlled in order to avoid utilization incompatible with their survival.".[30]

See also

References

  1. ^ Reid V. Moran (2009), "Rhodiola rosea Linnaeus, Sp. Pl. 2: 1035. 1753", Flora of North America online, vol. 8
  2. ^ a b Stace, C. A. (2010). New Flora of the British Isles (Third ed.). Cambridge, U.K.: Cambridge University Press. ISBN 9780521707725.
  3. ^ a b c d e "Rhodiola rosea L." Plants for a Future. 2012. Retrieved 28 February 2017.
  4. ^ a b Moran, Reid V, in Flora of North America. volume 8. pages 164-167
  5. ^ Anghelescu, Ion-George; Edwards, David; Seifritz, Erich; Kasper, Siegfried (2018-10-02). "Stress management and the role of Rhodiola rosea : a review". International Journal of Psychiatry in Clinical Practice. 22 (4): 242–252. doi:10.1080/13651501.2017.1417442. ISSN 1365-1501.
  6. ^ Pu, Wei-ling; Zhang, Meng-ying; Bai, Ru-yu; Sun, Li-kang; Li, Wen-hua; Yu, Ying-li; Zhang, Yue; Song, Lei; Wang, Zhao-xin; Peng, Yan-fei; Shi, Hong; Zhou, Kun; Li, Tian-xiang (2020-01-01). "Anti-inflammatory effects of Rhodiola rosea L.: A review". Biomedicine & Pharmacotherapy. 121: 109552. doi:10.1016/j.biopha.2019.109552. ISSN 0753-3322.
  7. ^ Panossian, A.; Wikman, G.; Sarris, J. (2010-06-01). "Rosenroot (Rhodiola rosea): Traditional use, chemical composition, pharmacology and clinical efficacy". Phytomedicine. 17 (7): 481–493. doi:10.1016/j.phymed.2010.02.002. ISSN 0944-7113.
  8. ^ William A Correll Jr. (5 February 2019). "(Example, one of several) Warning letter: Peak Nootropics LLC (aka Advanced Nootropics)". Inspections, Compliance, Enforcement, and Criminal Investigations, Center for Food Safety and Applied Nutrition, US Food and Drug Administration. Retrieved 14 March 2019.
  9. ^ Mitchell, LaTonya M (2 December 2015). "(Example, one of several) Warning letter: Nature's Health, LLC". Inspections, Compliance, Enforcement, and Criminal Investigations, US Food and Drug Administration. Retrieved 28 February 2017.
  10. ^ Emma R. Singleton (18 June 2013). "Warning letter: Herbs of Light, Inc". Inspections, Compliance, Enforcement, and Criminal Investigations, US Food and Drug Administration. Retrieved 28 February 2017.
  11. ^ "Rhodiolae roseae rhizoma et radix - herbal medicinal product | European Medicines Agency". www.ema.europa.eu. Retrieved 2024-01-18.
  12. ^ Xin, T.; Li, X.; Yao, H.; Lin, Y.; Ma, X.; Cheng, R.; Song, J.; Ni, L.; Fan, C.; Chen, S. (2015). "Survey of commercial Rhodiola products revealed species diversity and potential safety issues". Scientific Reports. 5: 8337. Bibcode:2015NatSR...5E8337X. doi:10.1038/srep08337. PMC 4321177. PMID 25661009.
  13. ^ Brinckmann, J.A.; Cunningham, A.B.; Harter, David E.V. (April 2021). "Running out of time to smell the roseroots: Reviewing threats and trade in wild Rhodiola rosea L". Journal of Ethnopharmacology. 269: 113710. doi:10.1016/j.jep.2020.113710. PMID 33358852. S2CID 229688390.
  14. ^ "Flora of the Canadian Arctic Archipelago - Rhodiola rosea L." nature.ca. Retrieved 2023-06-10.
  15. ^ a b "Rhodiola rosea". Drugs.com. 2019. Retrieved 9 October 2018.
  16. ^ Panossian A, Wikman G (2010). "Rosenroot (Roseroot): Traditional Use, Chemical Composition, Pharmacology, and Clinical Efficacy". Phytomedicine. 17 (5–6): 481–493. doi:10.1016/j.phymed.2010.02.002. PMID 20378318.
  17. ^ Evstavieva L.; Todorova M.; Antonova D.; Staneva J. (2010). "Chemical composition of the essential oils of Rhodiola rosea L. of three different origins". Pharmacogn Mag. 6 (24): 256–258. doi:10.4103/0973-1296.71782. PMC 2992135. PMID 21120024.
  18. ^ Mao, Yu; Li, Yan; Yao, Ning (November 2007). "Simultaneous determination of salidroside and tyrosol in extracts of Rhodiola L. by microwave assisted extraction and high-performance liquid chromatography". Journal of Pharmaceutical and Biomedical Analysis. 45 (3): 510–515. doi:10.1016/j.jpba.2007.05.031. PMID 17628386.
  19. ^ Anilakumar, Pooja, K.R.; Khanum, Farhath; Bawa, A.S. (2006-04). "PHYTOCONSTITUENTS AND ANTIOXIDANT POTENCY OF RHODIOLA ROSEA - A VERSATILE ADAPTOGEN". Journal of Food Biochemistry. 30 (2): 203–214. doi:10.1111/j.1745-4514.2006.00055.x. ISSN 0145-8884. {{cite journal}}: Check date values in: |date= (help)CS1 maint: multiple names: authors list (link)
  20. ^ Yousef, Gad G.; Grace, Mary H.; Cheng, Diana M.; Belolipov, Igor V.; Raskin, Ilya; Lila, Mary Ann (November 2006). "Comparative phytochemical characterization of three Rhodiola species". Phytochemistry. 67 (21): 2380–2391. doi:10.1016/j.phytochem.2006.07.026. PMID 16956631.
  21. ^ a b "Rhodiola". National Center for Complementary and Integrative Health, US National Institutes of Health. September 2016. Retrieved 28 February 2017.
  22. ^ Saratikov A.S. (1974). Golden Root (Rhodiola Rosea) (2nd ed.). Publishing House of Tomsk University. p. 158.
  23. ^ "Beluga - Noble Russian Vodka". www.vodka-beluga.com. Retrieved 2018-06-21.
  24. ^ Ishaque, Sana; Shamseer, Larissa; Bukutu, Cecilia; Vohra, Sunita (December 2012). "Rhodiola rosea for physical and mental fatigue: a systematic review". BMC Complementary and Alternative Medicine. 12 (1): 1208. doi:10.1186/1472-6882-12-70. PMC 3541197. PMID 22643043.
  25. ^ Pu, Wei-ling; Zhang, Meng-ying; Bai, Ru-yu; Sun, Li-kang; Li, Wen-hua; Yu, Ying-li; Zhang, Yue; Song, Lei; Wang, Zhao-xin; Peng, Yan-fei; Shi, Hong; Zhou, Kun; Li, Tian-xiang (2020-01-01). "Anti-inflammatory effects of Rhodiola rosea L.: A review". Biomedicine & Pharmacotherapy. 121: 109552. doi:10.1016/j.biopha.2019.109552. ISSN 0753-3322.
  26. ^ Anghelescu, Ion-George; Edwards, David; Seifritz, Erich; Kasper, Siegfried (2018-10-02). "Stress management and the role of Rhodiola rosea : a review". International Journal of Psychiatry in Clinical Practice. 22 (4): 242–252. doi:10.1080/13651501.2017.1417442. ISSN 1365-1501.
  27. ^ Panossian, A.; Wikman, G.; Sarris, J. (2010-06-01). "Rosenroot (Rhodiola rosea): Traditional use, chemical composition, pharmacology and clinical efficacy". Phytomedicine. 17 (7): 481–493. doi:10.1016/j.phymed.2010.02.002. ISSN 0944-7113.
  28. ^ "Rhodiolae roseae rhizoma et radix - herbal medicinal product | European Medicines Agency". www.ema.europa.eu. Retrieved 2024-01-18.
  29. ^ "IUCN red list".
  30. ^ "Appendices | CITES". cites.org. Retrieved 2023-06-10.
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