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Talk:Pernicious anemia

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This is an old revision of this page, as edited by SineBot (talk | contribs) at 20:06, 14 March 2024 (Signing comment by 70.49.18.153 - "Epidemiology - self-contradiction: "). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Source [7] & issues with data

Source 7 no longer exists, please link to the archive. Also, As far as I'm aware, it is impossible to gain B12 through a pill when the cause is through lack of intrinsic factor. Lacking intrinsic factor is what causes Pernicious Anemia to be an issue, and is why B12 is not absorbed through the body. A pill would not solve this, as, well, pills are absorbed through the stomach just as regular food is, and as such will be ignored due to the lack of intrinsic factor. As far as I am aware, this is only solvable with injections. — Preceding unsigned comment added by 31.121.173.154 (talk) 00:31, 1 February 2024 (UTC)[reply]

Exactly. Anyone with this illness should not be persuaded to buy B12 supplements as they won't work. 70.49.18.153 (talk) 20:03, 14 March 2024 (UTC)[reply]

April edits

I added some info about PA in a nice edit. Left to add is the relationship between PA and atrophic gastritis...


Understandable?

Do you current editors think this article is understandable? I stated in a previous entry that readers can look up the words they do not know, but is that fair enough? I'm just trying to keep this as legit, helpful, and understandable as possible for everyone. Thanks! OnFire4Jesus (talk) 03:17, 23 March 2008 (EST)

NEUROLOGICAL manifestations:

Neurological manifestations of B12 deficiency include:

Dementia,

Posterlateral sclerosis of the spinal cord,

peripheral neuropathy,

anosmia, and

optic nerve disease.

Pernicious anemia most usually presents via neurological symptoms in societies where food is fortified with folic acid (because folate-fortified foods obscure the better known megaloblastic anemia seen in red blood cells when inadequate B12 is accompanied by inadequate folate.

Epidemiology - self-contradiction

In leading section "Pernicious anemia due to autoimmune problems occurs in about one per 1000 people in the US. Among those over the age of 60, about 2% have the condition.". In Epidemiology section "PA is estimated to affect 0.1% of the general population and 1.9% of those over 60". Both statements have different citations, which support the figures given. BUT in US according to a quick Google search, ~16.8% of population is over 65 (so more than that must be over 60). 1.9% of 16.8% is 0.019 x 0.168 = 0.0032. So even if no-one under 65 has the condition, there should be over 3 per 1000 people with PA. I have no idea whether the correct figure is ~1 per 1000, or >3 per 1000, but they can't both be right.Newburyjohn (talk) 07:42, 31 May 2023 (UTC)[reply]

Are all citations fom the same date? from the same location? details do differ, as do raw data. — Preceding unsigned comment added by 70.49.18.153 (talk) 20:05, 14 March 2024 (UTC)[reply]