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User:Chairomai/Autoimmune skin diseases in dogs

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There are many autoimmune diseases, and they all vary in impact to the dog and progress at their own rates.

Reference Pedersen, Niels C. (1999) A Review of Immunologic Diseases of the Dog. Vet Immunol Immunopathol

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An autoimmune disease is a disease in which the immune system attacks the body of the infected animal.[1] In dogs, autoimmune skin diseases are usually not detected until visible symptoms appear, which differs from detection in humans who are able to verbally express their concerns.[2] Autoimmune skin diseases are characterized by damage to the connective tissue and vesicle formation located below the epidermis layer and the dermis layer.[3][4] Genetics, nutrition, and external environmental factors all collectively contribute to increasing the probability an autoimmune disease occurring.[5] The severity of symptoms varies based on the specific disease present and how far it has progressed. Diagnosis often requires the presence of visible symptoms and for a biopsy to be performed. For many diseases, the condition itself cannot be cured, but a veterinarian can prescribe medications and other forms of treatment to help manage the symptoms and discomfort of the dog.[6]

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Dogs suffering from autoimmune diseases of the skin may experience a variety of symptoms, including persistent itching and scratching, lesions, wounds, blisters, and other skin damage, as well as loss of skin pigment.[7] Two cases of autoimmune diseases that are often found include Discoid lupus erythematosus (DLE) and Pemphigus. DLE can develop into Systemic Lupus Erythematosus (SLE).[8] Most symptoms occur after the outer epidermis and inner dermis of the skin are affected by the disease. When this happens, the layers of the skin begin to separate, leading to painful lesions and pustules. The compromised integrity of the skin barrier not only exacerbates the discomfort experienced by the dog, but also heightens the risk of secondary bacterial infections. The weakening of the skin’s protective layers forms an environment susceptible to microbial infiltration, which could lead to severe complications. Intervening within an earlier time frame and targeted management strategies are essential to minimize further adverse effects.[9]

Another autoimmune skin disease which can occur in dogs is vitiligo. The exact prevalence of this disease in dogs is currently unknown, as it is likely under-reported.[2] In addition to humans, Vitiligo can be found in a variety of animals, including cats, horses, and dogs. Vitiligo is a type of autoimmune disease that damages melanocytes in the skin, lips, and oral cavity. Melanocytes are cells that contain pigments such as melanin. These pigments give rise to an organism's phenotype, which determines skin and hair color.[10] The affected melanocytes causes the skin and/or hair to become white or light pink. Melanocytes are also found in other parts of the body, such as the oral mucosa, eye, cochlea, and the meninges. Certain breeds of dogs have a higher chance of developing Vitiligo based on their genetics. These breeds include Rottweilers, German Shepherds, Old English Sheepdogs, Doberman Pinchers, Dachshunds, and German Shorthaired Pointers.[11] In addition to Vitiligo, there are other autoimmune diseases that target melanocytes, such as Vogt-Koyanagi-Harada (VKH) syndrome, and Uveodermatological (UDS) syndrome.[12]

When pemphigus occurs in humans, the skin will begin to blister due to antibodies attacking the adhesive proteins in epidermal cells, which causes them to separate. Different types of pemphigus can be identified based on the depth of separation present in the skin. Many forms of pemphigus can be identified in dogs using methods similar to those employed for humans.[13] Pemphigus vulgaris is rare in humans and animals, but is often fatal if left untreated. In dogs, the disease presents itself so similarly to the way it occurs in humans that dogs can be used as research models for the human disease.[6] When the disease first begins to manifest itself, lesions are usually evident in the oral cavity of the dog.[14] Aside from these blisters, the dog may be mostly asymptomatic before the disease progresses further.[6] The blisters are easily ruptured and become painful upon doing so,[6] which can cause the dog to have difficulty eating.[15] As the disease progresses, the infected dog can become severely infirm, and may succumb to further infection.[6] Sometimes symptoms are characterized by lymphadenopathy, which involves loss of appetite, weakness, fever, and in rare cases, sepsis.[14]

Pemphigus foliaceus is the most common autoimmune skin disease in dogs, making up around one-third of all canine autoimmune disorders.[16] This disease usually affects areas of the ears and face.[14] Early symptoms are characterized by depigmentation of the nasal palate, dorsal cleft in the mouth, the ear, and the periocular area around the eye. Itching, pain, and weakness of the body have been observed in some cases. Other symptoms of Pemphigus foliaceus include hair loss, formation of pustules, and erosions with ulcers. These symptoms can appear on the dog's feet, groin area, and trunk if left untreated.[16]

Disease incidence process

The immune system functions in many ways to eliminate foreign substances and particles introduced to the body. This revolves around T-cell differentiation, where mature T-cells with receptors for non-self cells target foreign antigens and act with other cells to dispose of them.[17] There are two mechanisms of tolerance found in the immune system. The first mechanism is positive selection by the thymus, where only T cells are selected. T cells recognize peptides in the Histocompatibility Complex (MHC). Foreign antigens possessing MHC molecules will then be

A nose-to-tail annual examination is recommended yearly to assess the dog and if there are any concerns raised further test such as skin biopsy, scans, or bloodwork will be collected to assist with diagnosis and potential treatments.

Diagnosis

Since many autoimmune skin diseases have similar symptoms and usually affect the oral cavity, a biopsy must often be performed in order to correctly diagnose the disease.[18]

Treatment

For most autoimmune skin diseases, it is imperative to begin treatment as early as possible, as the progression of the disease can lead to severe complications and even death.[6] Treatment for many diseases usually involves the use of immunosuppressants such as glucocorticoids.[18]

References

  1. ^ Gershwin, Laurel J. (2018-03). "Current and Newly Emerging Autoimmune Diseases". Veterinary Clinics of North America: Small Animal Practice. 48 (2): 323–338. doi:10.1016/j.cvsm.2017.10.010. ISSN 0195-5616. {{cite journal}}: Check date values in: |date= (help)
  2. ^ a b Tham, Heng L.; Linder, Keith E.; Olivry, Thierry (2019-07-19). "Autoimmune diseases affecting skin melanocytes in dogs, cats and horses: vitiligo and the uveodermatological syndrome: a comprehensive review". BMC Veterinary Research. 15 (1): 251. doi:10.1186/s12917-019-2003-9. ISSN 1746-6148. PMC 6639964. PMID 31324191.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link)
  3. ^ Papadogiannakis EI. 2005. Contemporary aspects of the immunopathogenesis of autoimmune diseases of the epidermal basement membrane in the dog. The Journal of the Hellenic Veterinary Medical Society 56(1) p 27-31.
  4. ^ "Structure of the Skin in Dogs - Dog Owners". Merck Veterinary Manual. Retrieved 2024-04-15.
  5. ^ Gershwin, Laurel J. (2010-05). "Autoimmune Diseases in Small Animals". Veterinary Clinics of North America: Small Animal Practice. 40 (3): 439–457. doi:10.1016/j.cvsm.2010.02.003. {{cite journal}}: Check date values in: |date= (help)
  6. ^ a b c d e f Fukushima, K. (1982-04). "Pathogenesis of pemphigus vulgaris in dog and man - a review". The Canadian Veterinary Journal = La Revue Veterinaire Canadienne. 23 (4): 135–137. ISSN 0008-5286. PMC 1790145. PMID 17422133. {{cite journal}}: Check date values in: |date= (help)
  7. ^ "Auto-immune Diseases". Archived from the original on 2019-10-30. Retrieved 2019-10-27.
  8. ^ Immune-mediated Skin Diseases. Rimini: 50th Congresso Nazionale Multisala SCIVAC
  9. ^ "Canine skin autoimmune diseases". Cornell University College of Veterinary Medicine. 2022-05-16. Retrieved 2024-03-04.
  10. ^ Yamaguchi, Yuji; Hearing, Vincent J. (2014-5). "Melanocytes and Their Diseases". Cold Spring Harbor Perspectives in Medicine. 4 (5): a017046. doi:10.1101/cshperspect.a017046. ISSN 2157-1422. PMC 3996377. PMID 24789876. {{cite journal}}: Check date values in: |date= (help)
  11. ^ "ScienceDirect.com | Science, health and medical journals, full text articles and books". www.sciencedirect.com. Retrieved 2024-02-25.
  12. ^ Tham, Heng L.; Linder, Keith E.; Olivry, Thierry (2019-07-19). "Autoimmune diseases affecting skin melanocytes in dogs, cats and horses: vitiligo and the uveodermatological syndrome: a comprehensive review". BMC Veterinary Research. 15 (1): 251. doi:10.1186/s12917-019-2003-9. ISSN 1746-6148.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  13. ^ Olivry, Thierry (2006-09-04). "A review of autoimmune skin diseases in domestic animals: I – Superficial pemphigus". Veterinary Dermatology. 17 (5): 291–305. doi:10.1111/j.1365-3164.2006.00540.x. ISSN 0959-4493.
  14. ^ a b c Immune-mediated Skin Diseases. Rimini: 50th Congresso Nazionale Multisala SCIVAC
  15. ^ Tham, Heng L.; Linder, Keith E.; Olivry, Thierry (2020-11-23). "Deep pemphigus (pemphigus vulgaris, pemphigus vegetans and paraneoplastic pemphigus) in dogs, cats and horses: a comprehensive review". BMC Veterinary Research. 16 (1): 457. doi:10.1186/s12917-020-02677-w. ISSN 1746-6148. PMC 7686683. PMID 33228633.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link)
  16. ^ a b "Canine skin autoimmune diseases". Cornell University College of Veterinary Medicine. 2022-05-16. Retrieved 2024-03-03.
  17. ^ Sprent, Jonathan; Kishimoto, Hidehiro (2001-05-29). Morris, P. J.; Wood, K. J. (eds.). "The thymus and central tolerance". Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 356 (1409): 609–616. doi:10.1098/rstb.2001.0846. ISSN 0962-8436. PMC 1088448. PMID 11375064.{{cite journal}}: CS1 maint: PMC format (link)
  18. ^ a b Bizikova, Petra; Linder, Keith E.; Anderson, Jamie G. (2023-06-01). "Erosive and ulcerative stomatitis in dogs and cats: which immune-mediated diseases to consider?". Journal of the American Veterinary Medical Association. 261 (S1): S48–S57. doi:10.2460/javma.22.12.0573.
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