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Draft:Adam Antebi

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Adam Antebi (*1961) is an American-born molecular biologist performing research on fundamental mechanisms underlying the processes of aging and longevity.[1] He currently serves as a director of the Max Planck Institute for Biology of Ageing in Cologne, Germany.[2] Antebi is recognized for his pioneering research on the molecular mechanisms regulating life span, particularly in model organisms such as C. elegans and the turquoise killifish. His work has elucidated several critical pathways involved in aging, and he continues to lead efforts to explore therapeutic targets that could enhance human health and lifespan.[3]

Life

Adam Antebi received his Bachelor’s degree with Distinction in Biochemistry from Swarthmore College, Pennsylvania, in 1983.[4] He went on to pursue his doctorate at the Massachusetts Institute of Technology (MIT) in the lab of Dr. Gerald Fink, completing his PhD in biology in 1991.[4] Following his PhD, Antebi conducted postdoctoral research at Johns Hopkins University under the mentorship of Dr. Edward M. Hedgecock.[4] During this period, he began his research on pathways regulating C. elegans developmental timing and longevity, establishing a foundation for his later work.[5][6]

From 1997, Dr. Antebi worked as a Max Planck Independent Group Leader at the Max Planck institute for Molecular Genetics, Berlin, and then moved to Baylor College of Medicine, Houston, Texas becoming an Associate Professor in 2007.[4]

In 2008, he joined the Max Planck Institute for Biology of Ageing as one of the founding Directors[4], where he has since focused on understanding the molecular underpinnings of aging and longevity.[7] He is also an Honorary Professor at the University of Cologne, Center of Excellence Cluster on Cellular Stress Responses and Ageing-associated Disease.[3][4]

Research Focus

Adam Antebi’s research is dedicated to uncovering the molecular processes and particularly convergent regulatory networks that govern aging and longevity. His lab employs various model organisms, such as the nematode C. elegans and the short-lived African killifish Nothobranchius furzeri, as well as mice and human cells.[7][3] Antebi's work has identified several key regulatory pathways—such as steroidal,[8] insulin/IGF, mTOR[9][10], microRNA[11] and AMPK signaling[12]—that play a role in maintaining cellular homeostasis and regulating lifespan.[13] His major discoveries include the regulation of animal life span by components of hormone driven developmental clocks,[8] and identifying small nucleoli as a cellular hallmark of longevity across taxa.[14]

His lab now investigates various aspects of convergent mechanisms of longevity, revealing how the fidelity of information flow - from transcription to chromatin state, splicing and translation - impact cellular dynamics and organismal life span. He is also unraveling how diapause states and fasting/ refeeding regimens influence metabolic networks, stem cell longevity, rejuvenation and senescence, as well as dissecting the relationship of inflammatory pathways with aging.[3]

Career

In 1997, Adam Antebi began his independent academic career as a Max Planck Independent Group Leader at the Max Planck institute for Molecular Genetics, Berlin.[4][15] In 2004 he became an Assistant Professor at the Baylor College of Medicine in Houston, Texas, where he advanced to Associate Professor in 2007. In 2008, he was appointed Director of the Department of Molecular Genetics of Ageing at the Max Planck Institute for Biology of Ageing in Cologne, Germany. He has also served as an honorary professor at the University of Cologne since 2010.[4]

Throughout his career, Dr. Antebi has contributed to the development of aging research as an organizer of major conferences and symposia, including the Gordon Research Conference on the Biology of Aging[16] and Cold Spring Harbor Asia Aging Conferences.[17] He has held significant roles as a Scientific Advisory Board (SAB) member for multiple institutions and organizations in Europe and worldwide.[4][18] He helped establish the Systems Biology of Ageing Network, Cologne[19] and served 16 years as an editor-in-chief for the scientific journal "Aging Cell", playing a key role in shaping the field of biogerontology research.[4]

He mentored a large number of graduate students and postdocs, many of whom moved on to become independent research group leaders and professors. Dr. Antebi served as the Director of the International Max Planck Research School, Ph.D. Program and helped establish the Cologne Graduate School of Ageing Research Ph.D. Program, for which he served as a Co-Director from 2013 to 2022.[4]

Awards and Honors

Adam Antebi’s contributions to aging research have been recognized through numerous prestigious awards and honors. He received the Breakthroughs in Gerontology Award from the American Federation for Aging Research/Glenn Foundation for Medical Research (2005), the DeBakey Excellence in Research Award from Baylor College of Medicine (2007), the Allianz/Associations de Prevoyance Sante (ADPS) Longevity Research Award (2016), and the Bennett J. Cohen Research in Aging Award (2021).[4][20] He also held the Runnström Lecture, Wenner-Gren Institute, University of Stockholm, Sweden (2009).[4]

From 2007 to 2012, Dr. Antebi was an Ellison Medical Foundation Senior Scholar in Aging.[4] He is an elected a member of the European Molecular Biology Organization (EMBO) since 2016[21] and of the Academy of Health and Lifespan Research since 2022.[22]

Adam Antebi was awarded the European Research Council (ERC) Advanced Grant for his research on nucleolar functions in aging in 2019,[23] and the Impetus Grant for targeting the nucleolus for phenotypic screens to discover lifespan extending drugs in 2023.[24]

References

  1. ^ "Antebi, Adam". www.mpg.de. Retrieved 2024-11-23.
  2. ^ "Prof., Dr. Adam Antebi". www.age.mpg.de. Retrieved 2024-11-23.
  3. ^ a b c d CECAD. "CECAD: Adam Antebi". www.cecad.uni-koeln.de. Retrieved 2024-11-23.
  4. ^ a b c d e f g h i j k l m n "Biography". www.age.mpg.de. Retrieved 2024-11-23.
  5. ^ Antebi, Adam; Culotti, Joseph G.; Hedgecock, Edward M. (1998-04-01). "daf-12 regulates developmental age and the dauer alternative in Caenorhabditis elegans". Development. 125 (7): 1191–1205. doi:10.1242/dev.125.7.1191. ISSN 0950-1991. PMID 9477318.
  6. ^ Antebi, Adam; Yeh, Wen-Hui; Tait, Danilo; Hedgecock, Edward M.; Riddle, Donald L. (2000-06-15). "daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans". Genes & Development. 14 (12): 1512–1527. doi:10.1101/gad.14.12.1512. ISSN 0890-9369.
  7. ^ a b "Research". www.age.mpg.de. Retrieved 2024-11-23.
  8. ^ a b Gerisch, Birgit; Rottiers, Veerle; Li, Dongling; Motola, Daniel L.; Cummins, Carolyn L.; Lehrach, Hans; Mangelsdorf, David J.; Antebi, Adam (2007-03-20). "A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling". Proceedings of the National Academy of Sciences. 104 (12): 5014–5019. doi:10.1073/pnas.0700847104. ISSN 0027-8424. PMC 1821127. PMID 17360327.
  9. ^ Nakamura, Shuhei; Karalay, Özlem; Jäger, Philipp S.; Horikawa, Makoto; Klein, Corinna; Nakamura, Kayo; Latza, Christian; Templer, Sven E.; Dieterich, Christoph; Antebi, Adam (2016-03-22). "Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals". Nature Communications. 7 (1): 10944. doi:10.1038/ncomms10944. ISSN 2041-1723. PMC 4804169. PMID 27001890.
  10. ^ Huang, Wenming; Kew, Chun; Fernandes, Stephanie de Alcantara; Löhrke, Anna; Han, Lynn; Demetriades, Constantinos; Antebi, Adam (2022-09-19). "Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity". Nature Aging. 2 (9): 796–808. doi:10.1038/s43587-022-00275-z. ISSN 2662-8465. PMC 10154236. PMID 37118503.
  11. ^ Shen, Yidong; Wollam, Joshua; Magner, Daniel; Karalay, Oezlem; Antebi, Adam (2012-12-14). "A Steroid Receptor–MicroRNA Switch Regulates Life Span in Response to Signals from the Gonad". Science. 338 (6113): 1472–1476. doi:10.1126/science.1228967. ISSN 0036-8075. PMC 3909774. PMID 23239738.
  12. ^ Ripa, Roberto; Ballhysa, Eugen; Steiner, Joachim D.; Laboy, Raymond; Annibal, Andrea; Hochhard, Nadine; Latza, Christian; Dolfi, Luca; Calabrese, Chiara; Meyer, Anna M.; Polidori, Maria Cristina; Müller, Roman-Ulrich; Antebi, Adam (2023-11-13). "Refeeding-associated AMPKγ1 complex activity is a hallmark of health and longevity". Nature Aging. 3 (12): 1544–1560. doi:10.1038/s43587-023-00521-y. ISSN 2662-8465. PMC 10724066. PMID 37957359.
  13. ^ "Antebi Adam - Search Results - PubMed". PubMed. Retrieved 2024-11-23.
  14. ^ Tiku, Varnesh; Jain, Chirag; Raz, Yotam; Nakamura, Shuhei; Heestand, Bree; Liu, Wei; Späth, Martin; Suchiman, H. Eka. D.; Müller, Roman-Ulrich; Slagboom, P. Eline; Partridge, Linda; Antebi, Adam (2017-08-30). "Small nucleoli are a cellular hallmark of longevity". Nature Communications. 8 (1): 16083. doi:10.1038/ncomms16083. ISSN 2041-1723. PMC 5582349. PMID 28853436.
  15. ^ "Alumni". www.molgen.mpg.de. Retrieved 2024-11-23.
  16. ^ "Biology of Aging - Gordon Research Conferences". www.grc.org. Retrieved 2024-11-23.
  17. ^ "WELCOME-Past 2017 Events-Cold Spring Harbor Asia". www.csh-asia.org. Retrieved 2024-11-23.
  18. ^ FMI. "Scientific Advisory Board". fmi.ch. Retrieved 2024-11-23.
  19. ^ "About us". www.sybacol.org. Retrieved 2024-11-23.
  20. ^ "Photo Gallery". www.bcm.edu. Retrieved 2024-11-23.
  21. ^ "Find people in the EMBO Communities". people.embo.org. Retrieved 2024-11-23.
  22. ^ "Adam Antebi, PhD". Academy for Health & Lifespan Research. Retrieved 2024-11-23.
  23. ^ "ERC-NUAGE". ERC. 2020-01-01. doi:10.3030/834259.
  24. ^ "Round 3: results announced". Longevity Impetus Grants. Retrieved 2024-11-23.
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