Synemin

synemin, desmuslin
synemin, desmuslin
Identifiers
Symbol	DMN
NCBI gene	23336
HGNC	14466
Other data
Locus	Chr. 15 q26.3

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Synemin, also called desmuslin, is an intermediate filament (IF) and, like other IFs, primarily functions to integrate mechanical stress and maintain structural integrity in eukaryotic cells. While it has been observed in a variety of cell types, it is has been best studied in the sarcomere of skeletal myocytes. It localizes at the Z-disk and has been shown to bind to both α-actinin and desmin to act as a mechanical linker in transmitting force laterally throughout the tissue, especially between the contractile myofibrils and extracellular matrix.

Two splice variant isoforms of synemin exist, α and β. Both isoforms have a very short N-terminal domain of 10 amino acids and a long C-terminal domain consisting of 1243 amino acids for the α isoform and 931 amino acids for the β isoform.^[1] An intronic sequence of the synemin β isoform is used as a coding sequence for synemin α.^[1]

References

^ ^a ^b Titeux; et al. (2001). "Human synemin gene generates splice variants encoding two distinct intermediate filament proteins". Eur J Biochem. 268 (24): 6435–49. PMID 11737198. {{cite journal}}: Explicit use of et al. in: |author= (help)

External links

Synemin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[titeux-1] Titeux; et al. (2001). "Human synemin gene generates splice variants encoding two distinct intermediate filament proteins". Eur J Biochem. 268 (24): 6435–49. PMID 11737198. {{cite journal}}: Explicit use of et al. in: |author= (help)

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