Calcium-sensing receptor
| calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CASR | ||||||
| Alt. symbols | HHC, HHC1 | ||||||
| NCBI gene | 846 | ||||||
| HGNC | 1514 | ||||||
| OMIM | 601199 | ||||||
| RefSeq | NM_000388 | ||||||
| UniProt | P41180 | ||||||
| Other data | |||||||
| Locus | Chr. 3 q21.1 | ||||||
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The calcium-sensing receptor is a G-protein coupled receptor which senses extracellular levels of calcium ion. In the parathyroid gland, the calcium-sensing receptor controls calcium homeostasis by regulating the release of parathyroid hormone.[1]
The drug cinacalcet is an allosteric modifier of the calcium-sensing receptor.[2]
References
- ^ D'Souza-Li L (2006). "The calcium-sensing receptor and related diseases". Arquivos brasileiros de endocrinologia e metabologia. 50 (4): 628–39. PMID 17117288.
- ^ Torres PU (2006). "Cinacalcet HCl: a novel treatment for secondary hyperparathyroidism caused by chronic kidney disease". Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 16 (3): 253–8. doi:10.1053/j.jrn.2006.04.010. PMID 16825031.
External links
- IUPHAR GPCR Database - Calcium-sensing receptors
- Receptors,+Calcium-Sensing at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- CASR+protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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