SMARCA4

SMARCA4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GRC, 2H60, 3UVD, 5DKD, 5EA1
Identifiers
Aliases	SMARCA4, BAF190, BAF190A, BRG1, MRD16, RTPS2, SNF2, SNF2L4, SNF2LB, SWI2, hSNF2b, CSS4, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
External IDs	OMIM: 603254; MGI: 88192; HomoloGene: 135927; GeneCards: SMARCA4; OMA:SMARCA4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.2 Start 10,961,001 bp End 11,065,395 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 A3|9 7.84 cM Start 21,527,465 bp End 21,615,526 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence tendon of biceps brachii ventricular zone amniotic fluid epithelium of nasopharynx sural nerve middle temporal gyrus primary visual cortex endothelial cell right hemisphere of cerebellum Top expressed in Rostral migratory stream otic vesicle hand ganglionic eminence mandibular prominence somite tail of embryo internal carotid artery Gonadal ridge maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding nucleotide binding transcription coactivator activity ATP-dependent activity, acting on DNA RNA polymerase I core promoter sequence-specific DNA binding helicase activity transcription corepressor activity protein N-terminus binding histone binding p53 binding transcription factor binding Tat protein binding DNA polymerase binding hydrolase activity, acting on acid anhydrides ATPase activity protein binding androgen receptor binding lysine-acetylated histone binding nucleosomal DNA binding hydrolase activity ATP binding RNA binding DNA binding Cellular component nBAF complex membrane SWI/SNF complex nucleoplasm npBAF complex nucleolus nucleus extracellular space protein-containing complex Biological process positive regulation of glucose mediated signaling pathway chromatin remodeling regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II positive regulation of transcription of nucleolar large rRNA by RNA polymerase I negative regulation of androgen receptor signaling pathway positive regulation of DNA-binding transcription factor activity negative regulation of transcription by RNA polymerase II transcription, DNA-templated nervous system development positive regulation of transcription, DNA-templated positive regulation of Wnt signaling pathway negative regulation of G1/S transition of mitotic cell cycle negative regulation of cell growth positive regulation of pri-miRNA transcription by RNA polymerase II positive regulation by host of viral transcription neural retina development positive regulation of transcription by RNA polymerase II beta-catenin-TCF complex assembly nucleosome disassembly negative regulation of transcription, DNA-templated chromatin organization interleukin-7-mediated signaling pathway RNA polymerase I preinitiation complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6597 20586 Ensembl ENSG00000127616 ENSMUSG00000032187 UniProt P51532 Q9HBD4 Q3TKT4 RefSeq (mRNA) NM_001128844 NM_001128845 NM_001128846 NM_001128847 NM_001128848 NM_001128849 NM_003072 NM_001174078 NM_001174079 NM_011417 NM_001357764 RefSeq (protein) NP_001122316 NP_001122317 NP_001122318 NP_001122319 NP_001122320 NP_001122321 NP_003063 NP_001361386 NP_001122321.1 NP_001167549 NP_001167550 NP_035547 NP_001344693 Location (UCSC) Chr 19: 10.96 – 11.07 Mb Chr 9: 21.53 – 21.62 Mb PubMed search
Wikidata
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SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4, also known as SMARCA4, is a human gene.