2-oxo-acid reductase

In enzymology, a 2-oxo-acid reductase (EC 1.1.99.30) is an enzyme that catalyzes the chemical reaction

a (2R)-hydroxy-carboxylate + acceptor $\rightleftharpoons$ a 2-oxo-carboxylate + reduced acceptor

Thus, the two substrates of this enzyme are (2R)-hydroxy-carboxylate and acceptor, whereas its two products are 2-oxo-carboxylate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (2R)-hydroxy-carboxylate:acceptor oxidoreductase. Other names in common use include (2R)-hydroxycarboxylate-viologen-oxidoreductase, HVOR, and 2-oxoacid reductase.

References

• Trautwein T, Krauss F, Lottspeich F, Simon H (1994). "The (2R)-hydroxycarboxylate-viologen-oxidoreductase from Proteus vulgaris is a molybdenum-containing iron-sulphur protein". Eur. J. Biochem. 222: 1025–32. PMID 8026480.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Neumann S and Simon H (1985). "On a non-pyridine nucleotide-dependent 2-oxoacid reductase of broad specificity from two Proteus species". FEBS Lett. 167: 29–32.

External links

The CAS registry number for this enzyme class is Template:CAS registry.