De Gradibus
De gradibus was an Arabic book published by the Arab physician Al-Kindi (c. 801–873 CE). De gradibus is the Latinized name of the book.
He describes there the original innovation of applying mathematics to pharmacology and specifically the quantification of the effect of drugs. For example, he developed a mathematical scale to quantify the strength of drugs. Al-Kindi was the first one who tried to use a serious quantification in medicine.[1]
He developed a mathematical scale to quantify the strength of a drug, and a system, based the phases of the Moon, that would allow a doctor to determine in advance the most critical days of a patient's illness.[2]
References
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