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Dextroamphetamine

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Dextroamphetamine
Clinical data
Pregnancy
category
  • AU: B3
Routes of
administration		Clinical: Oral, intravenous, sublingual
Recreational: Vaporized, insufflated, suppository
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability>75%
MetabolismHepatic
Elimination half-life10–28 hours
(Average ~12 hours)
ExcretionRenal: ~45%
Identifiers
  • (2S)-1-phenylpropan-2-amine
CAS Number
PubChem CID
DrugBank
CompTox Dashboard (EPA)
ECHA InfoCard100.000.103 Edit this at Wikidata
Chemical and physical data
FormulaC9H13N
Molar mass135.206 g/mol g·mol−1

Dextroamphetamine is a psychostimulant which produces increased wakefulness, energy and self-confidence in association with decreased fatigue and appetite. It is perhaps the archetypal psycho-stimulant, and drugs with similar psychoactive properties are often referred to as "amphetamine analogues", or described as having "amphetamine-like", or even "amphetaminergic" effects. Its stimulant properties are similar to those of methylphenidate and methamphetamine, though with a slower onset of action and a duration that lies somewhere between the two.[citation needed]

Dextroamphetamine is the dextrorotary stereoisomer of the amphetamine molecule, which can take two different forms. Other common names for dextroamphetamine include d-amphetamine, dexamphetamine, (S)-(+)-amphetamine, and brand names such as Dexedrine and Dextrostat. It is combined with racemic-amphetamine in the ADHD drug Adderall. It is the active metabolite of the recently introduced prodrug lisdexamfetamine, known by its brand name Vyvanse. In addition, it is an active metabolite of several older N-substituted amphetamine prodrugs used as anorectics, such as clobenzorex (Asenlix) and amphetaminil (Aponeuron).

History

Amphetamine was first synthesized under the chemical name "phenylisopropylamine" in Berlin, 1887 by the Romanian chemist Lazar Edeleanu. It was not widely marketed until 1932, when the pharmaceutical company Smith, Kline, and French (currently known as GlaxoSmithKline) introduced it in the form of the Benzedrine Inhaler, for combating cold symptoms. Notably, the chemical form of Benzedrine in the inhaler was the liquid-free base, not a chloride or sulfate salt. In free-base form, amphetamine is a volatile oil, hence the efficacy of the inhalers.

Three years later, in 1935, the medical community became aware of the stimulant properties of amphetamine, specifically dextroamphetamine, and in 1937 Smith, Kline, and French introduced Dexedrine tablets, under the tradename Dexedrine. In the United States, Dexedrine tablets were approved to treat narcolepsy, attention disorders, depression, and obesity. Dextroamphetamine was marketed in various other forms in the following decades, primarily by Smith, Kline, and French, such as several combination medications including a mixture of dextroamphetamine and amobarbital (a barbiturate) sold under the tradename Dexamyl and, in the 1950s, an extended release capsule (the "Spansule").

It quickly became apparent that Dexedrine and other amphetamines had a high potential for abuse, although they were not heavily controlled until 1970, when the Comprehensive Drug Abuse Prevention and Control Act was passed by the United States Congress. Dexedrine, along with other sympathomimetics, was eventually classified as schedule II, the most restrictive category possible for a drug with recognized medical uses.

Indications

Dextroamphetamine is useful for those with ADHD and Narcolepsy. It improves self-control for people who have a hard time naturally controlling themselves.[2] Dextroamphetamine aids a person learning and memory of words, and perhaps makes the brain stronger.[3] When a person given dextroamphetamine is tested, their brain is extremely active in the brain parts required for the test and radically less active in other parts.[4] Short practice sessions with dextroamphetamine have a greater effect on learning than sessions without dextroamphetamine.[3][4] Dextroamphetamine raises decision-making scores, improves choices, and changes beliefs about rewards; at the same time, dextroamphetamine barely—if at all—affects guesses of time.[2] Those who feel lower amounts of joy from dextroamphetamine have greater impulsivity improvements compared to those who feel extreme happiness.[2]

Contraindications

The drug should be avoided for those who have: hypersensitivity to amphetamines, a history of drug abuse, cardiovascular diseases, hypertensive disease, hyperthyroidism, or in those with glaucoma. also if you are on any MAOI medications or meds like buspar it can have adverse reactions. Don't mix meds unless you know there is no contraindications.JonM.D. (talk) 10:12, 25 December 2007 (UTC)

Adverse effects

Side effects

Cardiovascular: Palpitations, tachycardia, elevation of blood pressure, arythmia.

Central Nervous System: Psychotic episodes at recommended doses (rare), overstimulation, restlessness, dizziness, insomnia, euphoria, dyskinesia, dysphoria, tremor, headache, exacerbation of motor and phonic tics and Tourette's syndrome.

Gastrointestinal: Dryness of the mouth, unpleasant taste, diarrhea, constipation, stomach pain or discomfort. other gastrointestinal disturbances. Anorexia or weight loss may occur as undesirable effects when amphetamines are used for other than the anorectic effect.

Allergic: Urticaria.

Endocrine: Impotence, changes in libido.

[5]

Withdrawal

Withdrawal from Dextroamphetamines can have various psychological and physical effects if halted mid-course due to an induced dependency. Such symptoms may include fatigue, psychomotor retardation, hypersomnia, panic attacks, paranoia, palpatations, arythmia, lack of motivation, difficulty concentrating, increased appetite, dysphoria, irritability or agression, stomach and chest pain, joint and muscle pain, weak immune system, tremors, decreased reactions and adrenaline rushes, lack of inhibition do to urges to get ahold of more stimulants, etc. It is recommended that prescription users consult their doctor before attempting to stop or limit their dosage of daily amphetamine intake. [6][7][8][9]

Overdose

The Physician's 1991 Drug Handbook reports: "Symptoms of overdose include restlessness, tremor, hyperreflexia, tachypnea, confusion, aggressiveness, hallucinations, and panic." Dilated pupils are common with high doses.

The fatal dose in humans is not precisely known, but in various species of rat generally ranges between 50 and 100 mg/kg, or a factor of 100 over what is required to produce noticeable psychological effects.[10][11] This suggests a wide therapeutic range[citation needed], in contrast to such drugs as morphine and heroin, where effective doses may be as much as 50% of a fatal dose[citation needed]. Although the symptoms seen in a fatal overdose are similar to those of methamphetamine, their mechanisms are not identical, as some substances which inhibit d-amphetamine toxicity do not do so for methamphetamine.[12][13]

An extreme symptom of overdose is amphetamine psychosis, characterized by vivid visual, auditory, and sometimes tactile hallucinations. Many of its symptoms are identical to the psychosis-like state which follows long-term sleep deprivation, so it remains unclear whether these are solely the effect of the drug, or due to the long periods of sleep deprivation which are often undergone by the chronic user or abuser. "In extraordinarily sensitive individuals, psychosis may be produced by 55 to 75 mg of dextroamphetamine. With high enough doses, psychosis can probably be induced in anyone." Amphetamine psychosis, however, is extremely rare in individuals taking oral amphetamines at therapeutic doses; it is usually seen in cases of prolonged or high-dose intravenous (IV) abuse.[14]

Chemistry

Dextroamphetamine is a slightly polar, weak base and is lipophilic.

Formulations

Dextroamphetamine sulfate

5mg dexamphetamine sulfate tablets

A tablet preparation of the salt dextroamphetamine sulfate (pharmaceutical names: Dexedrine or Dextrostat) is available in only a 5mg strength in the United States A pharmaceutical with a strength of 30 mg dextroamphetamine sulfate is 22.0 mg dextroamphetamine.

File:Dexedrine Spansules.jpg
Sustained-Release 15 mg Dexedrine Spansules

Dextroamphetamine sulfate is also available in a controlled release version (pharmaceutical name: Dexedrine SR or Dexedrine Spansule), capsulated in the strengths: 5 mg, 10 mg, and 15 mg.

Lisdexamfetamine

Main article: Lisdexamfetamine

Dextroamphetamine is also the active metabolite of the prodrug lisdexamfetamine dimesylate (pharmaceutical name: Vyvanse). Vyvanse is meant to provide once-a-day dosing because it regulates a slow release of dextroamphetamine into the brain. Vyvanse is available as capsules, in three strengths: 30 mg, 50 mg, and 70 mg. A 30 mg-strength Vyvanse capsule is molecularly equivalent to 8.88 mg dextroamphetamine. However, this molecular equivalence would only hold true as a bioequivalence ratio if: the dimesylate salt instantly dissolved resulting in the complete dissociation of lisdexamfetamine ions, and then the covalent amide bond of every lisdexamfetamine molecule immediately underwent hydrolysis. In fact, being a prodrug, lisdexamfetamine has different properties than dextroamphetamine; for instance, lisdexamfetamine is metabolised in the gastrointestinal tract, while dextroamphetamine's metabolism is hepatic.[15]

Vyvanse is also being marketed for its lower abuse and misuse potential than when compared to similar drugs such as Adderall, Dexedrine, and the methylphenidate preparations, though it is still rated as a Schedule II drug by the U.S. Drug Enforcement Administration. Vyvanse significantly slower onset and its route of administration is limited to being taken orally, unlike many similar drugs which are commonly nasally insufflated to achieve a much faster onset and higher bioavailability. Since Vyvanse is a prodrug and thus not psychoactive it must be metabolized into dextroamphetamine first before having psychoactive effects. Insufflation of Vyvanse is expected to produce no stimulant property, though this is disputed by the DEA.

Mixed amphetamine salts

File:Adderall 30mg small.jpg
Instant Release 30 mg Adderall Tablets

Another pharmaceutical that contains dextroamphetamine is Adderall. The drug formulation of Adderall (both controlled and instant release forms) is:

One-quarter racemic (d,l-)amphetamine aspartate monohydrate
One-quarter dextroamphetamine saccharate
One-quarter dextroamphetamine sulfate
One-quarter racemic (d,l-)amphetamine sulfate

Aspartate, saccharate, and sulfate salts differ pharmacokinetically in the rate at which they are metabolized by the body. For this and other reasons, Adderall's effects are different from pharmaceuticals with dextroamphetamine as an exclusive active ingredient. Contrary to the beliefs that Adderall is three-quarters dextroamphetamine, dextroamphetamine accounts for 72.7% of the amphetamine base in Adderall (the remaining percentage is levoamphetamine). Adderall’s inclusion of levoamphetamine provides the pharmaceutical with a quicker onset and longer clinical effect compared to pharmaceuticals exclusively formulated of dextroamphetamine.[16] Although it seems that where the human brain has a preference for dextroamphetamine over levoamphetamine, it has been reported that certain children have a better clinical response to levoamphetamine.[17]

Uses

Clinical

  • Primarily used to treat attention deficit hyperactivity disorder (ADHD). In some localities it has replaced methylphenidate as the first-choice medication for ADHD, a role in which it is considered highly effective.
  • Treatment of Narcolepsy, generally where non-pharmacological measures have proved insufficient.
  • Occasionally prescribed for weight-loss in cases of extreme treatment-resistant obesity.

Experimental

Though such use remains out of the mainstream, dextroamphetamine has been successfully applied in the treatment of certain categories of depression as well as other psychiatric syndromes.[18] Such alternate uses include reduction of fatigue in cancer patients, antidepressant treatment for HIV patients with depression and debilitating fatigue,[19] early stage physiotherapy for severe stroke victims,[20] If physical therapy patients take dextroamphetamine while they practice their movements for rehabilitation, they learn to move much faster than without dextroamphetamine, and in practice sessions with shorter lengths.[3]

Military

The U.S. Air Force uses dextroamphetamine as its "go-pill,", given to pilots on long missions to help them remain focused and alert.[21][22] (Friendly Fire incidents have been linked to the use of this drug and its effects on long term fatigued pilots; e.g. Tarnak Farm incident) newer stimulant medications with fewer side effects, like modafinil are being investigated for this reason.[citation needed]

Illicit

Along with Ritalin and Adderall, illicit use of dextroamphetamine has been reported among students, both as a study aid, social aid, and for purely recreational purposes. According to the National Institute on Drug Abuse, 4% of American college students reported non-prescription stimulant use in 2004.[23]


Pharmacology

Effect on neurochemistry

Dextroamphetamine affects the dynamics neurotransmitter systems, and its mechanisms of action are continuously being investigated and discovered.

Monoamines

Dextroamphetamine affects dopamine and serotonin levels in the caudate, and norepinephrine in the hippocampus. Because dextroamphetamine is a substrate analog at monoamine transports, at all doses, dextroamphetamine prevents the reuptake of these neurotransmitters,[24] causing them to remain in the synaptic cleft for a prolonged period (inhibiting monoamine reuptake in rats with a norepinephrine to dopamine ratio (NE:DA) of about 1:1 and a norepinephrine to 5-hydroxytryptamine ratio (NE:5HT) of about 1:10[25]). At some point, when doses are high, and the concentration of dextroamphetamine is high enough,[24] dextroamphetamine will enter nerve cells and cause release of monoamines from the cytoplasmic dopamine pool (as opposed to 'protected' vesicular stores).[26] In such high concentrations, dextroamphetamine will cause the norepinephrine, dopamine and serotonin (5HT) transporters to reverse their direction of flow. This inversion leads to a release of these transmitters from the vesicles to the cytoplasm and from the cytoplasm to the synapse (releasing monoamines in rats with ratios of about NE:DA = 1:3.5 and NE:5HT = 1:250), causing increased stimulation of post-synaptic receptors.

Glutamate

Dextroamphetamine does not alter glutamate levels in the prefrontal cortex. This may be because dextroamphetamine increases dopamine release in the prefrontal cortex; activation of the dopamine-2 receptors inhibits glutamate release in the prefrontal cortex. However, activation of the dopamine-1 receptors in the prefrontal cortex, increases glutamate leves in the nucleus accumbens. An increase of the glutamate levels in the nucleus accumbens may be part of the reason that dextroamphetamine has an ability to increase locomotor activity in rats. Serotonin may also play a role in dextroamphetamines affect on glutamate levels.[27]

Time course and elimination

On average, about one half of a given dose is eliminated unchanged in the urine, while the other half is broken down into various metabolites (mostly benzoic acid).[28] However, the drug's half-life is highly variable because the rate of excretion is very sensitive to urinary pH. Under alkaline conditions, direct excretion is negligible and 95%+ of the dose is metabolized. The main metabolic pathway is d-amphetamine phenylacetone benzoic acid hippuric acid. Another pathway, mediated by enzyme CYP2D6, is d-amphetamine p-hydroxyamphetamine p-hydroxynorephedrine. Although p-hydroxyamphetamine is a minor metabolite (~5% of the dose), it may have significant physiological effects as a norepinephrine analogue.[29]

Subjective effects are increased by larger doses, however, over the course of a given dose there is a noticeable divergence between such effects and drug concentration in the blood.[30] In particular, mental effects peak before maximal blood levels are reached, and decline as blood levels remain stable or even continue to increase.[31][32][33] This indicates a mechanism for development of acute tolerance, perhaps distinct from that seen in chronic use. Its slower onset of action as compared to methamphetamine and methylphenidate is presumably due to a somewhat lower effectiveness in crossing the blood-brain barrier.[34]

References

  • Poison Information Monograph (PIM 178: Dexamphetamine Sulphate)
  • Physician's 1991 Drug Handbook
  • Dexamphetamine . GPnotebook https://www.gpnotebook.co.uk/simplepage.cfm?ID=1845887055. {{cite web}}: Missing or empty |title= (help)
  • Package inserts: "New Zealand". "Canada".
  • Yamada H, Baba T, Hirata Y, Oguri K, Yoshimura H (1984). "Studies on N-demethylation of methamphetamine by liver microsomes of guinea-pigs and rats: the role of flavin-containing mono-oxygenase and cytochrome P-450 systems". Xenobiotica. 14 (11): 861–6. PMID 6506758.{{cite journal}}: CS1 maint: multiple names: authors list (link)

Footnotes

  1. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
  2. ^ a b c de Wit H, Enggasser JL, Richards JB (2002). "Acute Administration of D-Amphetamine Decreases Impulsivity in Healthy Volunteers". Neuropsychopharmacology. 27: 813–825. PMID 12431855.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ a b c Butefisch CM; et al. (2002). "Modulation of Use-Dependent Plasticity by D-Amphetamine". Annals of Neurology. 51 (1): 59–68. PMID 11782985. {{cite journal}}: Explicit use of et al. in: |author= (help)
  4. ^ a b Cite error: The named reference Mattay was invoked but never defined (see the help page).
  5. ^ http://www.healthoptions.com/dexedrine.html
  6. ^ "DEXAMPHETAMINE - CMI".
  7. ^ "What should I watch for while taking dextroamphetamine?".
  8. ^ "Tolerance Page 2" (PDF).
  9. ^ "What are the possible side effects of dextroamphetamine?".
  10. ^ Miczek K (1979). "A new test for aggression in rats without aversive stimulation: differential effects of d-amphetamine and cocaine" (Abstract). Psychopharmacology (Berl). 60 (3): 253–9. doi:10.1007/BF00426664. PMID 108702.
  11. ^ Grilly D, Loveland A (2001). "What is a "low dose" of d-amphetamine for inducing behavioral effects in laboratory rats?". Psychopharmacology (Berl). 153 (2): 155–69. PMID 11205415.
  12. ^ Derlet R, Albertson T, Rice P (1990). "Antagonism of cocaine, amphetamine, and methamphetamine toxicity". Pharmacol Biochem Behav. 36 (4): 745–9. PMID 2217500.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  13. ^ Derlet R, Albertson T, Rice P (1990). "The effect of SCH 23390 against toxic doses of cocaine, d-amphetamine and methamphetamine". Life Sci. 47 (9): 821–7. PMID 2215083.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  14. ^ LS Goodman, A Gilman (1970). The Pharmacological Basis of Therapeutics (7th Ed. ed.). New York: Macmillan Co. {{cite book}}: |edition= has extra text (help)
  15. ^ FDA Approval of Vyvanse Pharmacological Reviews Pages 18 and 19
  16. ^ Glaser; et al. (2005). "Differential Effects of Amphetamine Isomers on Dopamine in the Rat Striatum and Nucleus Accumbens Core". Psychopharmacology. 178: 250-258 (Pages: 255, 256). {{cite journal}}: Explicit use of et al. in: |author= (help)
  17. ^ Arnold (2000). "Methylphenidate vs Amphetamine: Comparative Review". Journal of Attention Disorders. 3 (4): 200–211. doi:10.1177/108705470000300403.
  18. ^ Warneke L (1990). "Psychostimulants in psychiatry". Can J Psychiatry. 35 (1): 3–10. PMID 2180548.
  19. ^ Wagner G, Rabkin R (2000). "Effects of dextroamphetamine on depression and fatigue in men with HIV: a double-blind, placebo-controlled trial". J Clin Psychiatry. 61 (6): 436–40. PMID 10901342.
  20. ^ Martinsson L, Yang X, Beck O, Wahlgren N, Eksborg S (2003). "Pharmacokinetics of dexamphetamine in acute stroke". Clin Neuropharmacol. 26 (5): 270–6. PMID 14520168. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  21. ^ http://www.commondreams.org/headlines02/0801-06.htm
  22. ^ Emonson DL, Vanderbeek RD. (1995) The use of amphetamines in U.S. Air Force tactical operations during Desert Shield and Storm. 66(8):802
  23. ^ NIDA Notes Volume 20, Number 4 (March 2006)
  24. ^ a b Kuczenski R; et al. (1995). "Hippocampus Norepinephrine, Caudate Dopamine and Serotonin, and Behavioral Responses to the Stereoisomers of Amphetamine and Methamphetamine". The Journal of Neuroscience. 15 (2): 1308–1317. PMID 7869099. {{cite journal}}: Explicit use of et al. in: |author= (help) Free full text (PDF)
  25. ^ Rothman, et al. "Amphetamine-Type Central Nervous System Stimulants Release Norepinephrine more Potently than they Release Dopamine and Serotonin." (2001): Synapse 39, 32–41 (Table V. on page 37)
  26. ^ Patrick, and Markowitz (1997). "Pharmacology of Methylphenidate, Amphetamine Enantiomers and Pemoline in Attention-Deificit Hyperacitivty Disorder". Human Psychopharmacology. 12: 527-546 (Page:530).
  27. ^ Cite error: The named reference Shoblock was invoked but never defined (see the help page).
  28. ^ Mofenson H, Greensher J (1975). "Letter: Physostigmine as an antidote: use with caution". J Pediatr. 87 (6 Pt 1): 1011–2. PMID 1185381.
  29. ^ Rangno R, Kaufmann J, Cavanaugh J, Island D, Watson J, Oates J (1973). "Effects of a false neurotransmitter, p-hydroxynorephedrine, on the function of adrenergic neurons in hypertensive patients" (Scanned copy). J Clin Invest. 52 (4): 952–60. PMID 4348345.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  30. ^ Asghar S, Tanay V, Baker G, Greenshaw A, Silverstone P (2003). "Relationship of plasma amphetamine levels to physiological, subjective, cognitive and biochemical measures in healthy volunteers". Hum Psychopharmacol. 18 (4): 291–9. PMID 12766934.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  31. ^ Angrist B, Corwin J, Bartlik B, Cooper T (1987). "Early pharmacokinetics and clinical effects of oral D-amphetamine in normal subjects". Biol Psychiatry. 22 (11): 1357–68. PMID 3663788.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  32. ^ Brown G, Hunt R, Ebert M, Bunney W, Kopin I (1979). "Plasma levels of d-amphetamine in hyperactive children. Serial behavior and motor responses" (Abstract). Psychopharmacology (Berl). 62 (2): 133–40. doi:10.1007/BF00427126. PMID 111276.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  33. ^ Brauer L, Ambre J, De Wit H (1996). "Acute tolerance to subjective but not cardiovascular effects of d-amphetamine in normal, healthy men". J Clin Psychopharmacol. 16 (1): 72–6. PMID 8834422.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  34. ^ MacKenzie R, Heischober B (1997). "Methamphetamine". Pediatr Rev. 18 (9): 305–9. PMID 9286149.
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