Talk:Sodium thiopental

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I have deleted the second reference - it was a link to some Dutch kid's birthday page. Not appropriate for a page on Sodium Pentathol.

kinske9@aol.com

How can one tell?

How can one tell if he was submitted to pentathol i.e. while he was committed and given shots of antipsychotics. I have memory blanks and other difficult symptoms that are not on adverse list for neither Risperdal nor Haloperidol?

Thanks -- Mtodorov 69 13:14, 10 May 2006 (UTC)[reply]

Barbituate, or Benzo?

"Barbiturates, with the exception of intravenous diazepam, do not have analgesic effects."

I would assume that diazepam is a bezodiazepam and not a barbituate, no matter how it is administered?

Doh, wow... my mistake. I was writing on barbiturates so much... Thanks. ER MD 05:03, 20 June 2006 (UTC)[reply]

Speaking of that line, It says they have anaesthetic effects, but not analgesic effects. What's the difference?

An-algesic - means 'no algesia', no pain.

An-aesthetic - means 'no aesthetic', no awareness.

You can be under an anaesthetic but without being given an analgesic, the body will still respond as if it is in pain (ie increase heart rate, increase blood pressure, release adrenaline etc). —Preceding unsigned comment added by 165.118.1.50 (talk) 00:24, 7 January 2008 (UTC)[reply]

Half life and zero order elimination kinetics

If sodium thiopental is eliminated according to zero order kinetics, I would say it is not appropriate to refer to a half life (under 'medically induced coma'). According to zero order kinetics, the amount of time required to reduce the blood concentration by one half is a function of the amount initially present.

Asteen 19:05, 12 March 2007 (UTC)[reply]

1. Thiopental is eliminated according to zero order kinetics at higher doses. It is eliminated via 1st order kinetics at lower doses.

2. I agree, elimination half-life is not appropriate. Thiopental is not used by infusion becuase of it's Context Sensitive Half Time (CSHT). ie. The longer the infusion continues (time = context), the more drug deposited in preipheral tissues. When the infusion is stopped, the drug re-distributes to the plasma, continuing the effect (they take a much longer time to wake up). This is added to the Zero Order Clearance at high doses (CSHT takes this into account).

3. Zero Order Kinetics: Clearance is independent of concentration of drug. First Order Kinetics: Clearance is dependent on concnetration of drug. —Preceding unsigned comment added by 165.118.1.50 (talk) 00:22, 7 January 2008 (UTC)[reply]