Glial cell line-derived neurotrophic factor

GDNF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2V5E, 3FUB, 4UX8
Identifiers
Aliases	GDNF, ATF1, ATF2, HFB1-HSCR3, glial cell derived neurotrophic factor, ATF
External IDs	OMIM: 600837; MGI: 107430; HomoloGene: 433; GeneCards: GDNF; OMA:GDNF - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	37,840,041 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	7,867,056 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; tibialis anterior muscle; ; deltoid muscle; ; Skeletal muscle tissue of biceps brachii; ; muscle layer of sigmoid colon; ; gastrocnemius muscle; ; Skeletal muscle tissue of rectus abdominis; ; quadriceps femoris muscle; ; gastric mucosa; ; mucosa of ileum;
	Top expressed in
	medullary collecting duct; ; inner muscle layer; ; muscularis mucosae; ; renal corpuscle; ; Hindgut; ; Bowman's capsule; ; epithelium of small intestine; ; migratory enteric neural crest cell; ; genitourinary system; ; Gonadal ridge;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; protein binding; growth factor activity; signaling receptor binding; chemoattractant activity involved in axon guidance;
Cellular component	extracellular region; intracellular anatomical structure; extracellular space;
Biological process	peristalsis; ureteric bud development; regulation of dopamine uptake involved in synaptic transmission; peripheral nervous system development; sympathetic nervous system development; organ induction; adult locomotory behavior; positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; regulation of stem cell differentiation; regulation of morphogenesis of a branching structure; mesenchymal to epithelial transition involved in metanephros morphogenesis; negative regulation of apoptotic process; nervous system development; positive regulation of monooxygenase activity; enteric nervous system development; mRNA stabilization; branching involved in ureteric bud morphogenesis; postganglionic parasympathetic fiber development; positive regulation of dopamine secretion; neural crest cell migration; postsynaptic membrane organization; positive regulation of cell population proliferation; positive regulation of cell differentiation; positive regulation of ureteric bud formation; ureteric bud formation; regulation of gene expression; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; metanephros development; neuron projection development; signal transduction; positive regulation of transcription by RNA polymerase II; MAPK cascade; axon guidance; negative regulation of neuron apoptotic process; positive regulation of branching involved in ureteric bud morphogenesis; regulation of signaling receptor activity; dorsal spinal cord development; embryonic organ development; chemoattraction of axon; commissural neuron axon guidance; regulation of semaphorin-plexin signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2668
	14573
	ENSG00000168621
	ENSMUSG00000022144
	P39905
	P48540
NM_000514; NM_001190468; NM_001190469; NM_001278098; NM_199231;
	NM_199234
	NM_010275; NM_001301332; NM_001301333; NM_001301357
	NP_000505; NP_001177397; NP_001177398; NP_001265027; NP_954701
	NP_001288261; NP_001288262; NP_001288286; NP_034405
	Wikidata
View/Edit Human	View/Edit Mouse

Template:PBB Controls

Glial cell derived neurotrophic factor, also known as GDNF, is a small protein that potently promotes the survival of many types of neurons ^[5]

Template:PBB Summary

Functions

The most prominent feature of GDNF is its ability to support the survival of dopaminergic and motorneurons.

These neuronal populations die in the course of Parkinson's disease and amyotrophic lateral sclerosis (ALS) respectively. GDNF also regulates kidney development and spermatogenesis. thias is ass cheese

GDNF family of ligands (GFL)

GDNF is a founding member of the GDNF family of ligands (GFL).

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168621 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022144 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GDNF glial cell derived neurotrophic factor".

External links

Glial+Cell+Line-Derived+Neurotrophic+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168621 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022144 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GDNF glial cell derived neurotrophic factor".

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[5]

v t e Cell signaling: Nervous tissue: Neurotrophic factors
Neurotrophins	NGF BDNF NT-3 NT-4
GDNF family	GDNF Artemin Neurturin Persephin
Ephrins	A1 A2 A3 A4 A5 B1 B2 B3
CNTF family	CNTF LIF IL-6
Other	GMF IGF-1 Neuregulins 1 2 3 4 PACAP VEGF

Functions

GDNF family of ligands (GFL)

References

Further reading

External links