GLUT2
| solute carrier family 2 (facilitated glucose transporter), member 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | SLC2A2 | ||||||
| Alt. symbols | GLUT2 | ||||||
| NCBI gene | 6514 | ||||||
| HGNC | 11006 | ||||||
| OMIM | 138160 | ||||||
| RefSeq | NM_000340 | ||||||
| UniProt | P11168 | ||||||
| Other data | |||||||
| Locus | Chr. 3 q26.2-q27 | ||||||
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GLUT 2 is a transmembrane carrier protein and gene which is involved in passive glucose transport, especially the renal glucose reabsorption.
Locations
It is found in cellular membranes of:
- liver
- pancreatic beta cells
- hypothalamus
- basolateral membrane of small intestine
- basolateral membrane of renal tubular cells
Function
It has high capacity but low affinity (high Km, ca. 5 mM) part of "the glucose sensor" in pancreatic β-cells. It is a very efficient carrier for glucose.
It may also carry glucosamine, suspected because mouse embryos lacking this glucose carrier protein/gene- and its suspected capacity to transport glucosamine- soon die. According to genetics researchers in neonatal and maternal-fetal medicine at Harvard University Medical School and Beth-Israel Deaconess Hospital Medical Center, this creates a problem for diabetic pregnancies in which glucose levels in the woman are uncontrolled, exposing her fetus to the possibility of neural tube and cardiac defects in the early-developing brain, spine, and heart.
See also
External links
- MeSH entry: Glucose Transporter Type 2
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