UCP2

UCP2
Identifiers
Aliases	UCP2, BMIQ4, SLC25A8, UCPH, uncoupling protein 2
External IDs	OMIM: 601693; MGI: 109354; HomoloGene: 2516; GeneCards: UCP2; OMA:UCP2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.4 Start 73,974,672 bp End 73,983,246 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 E2|7 54.36 cM Start 100,142,544 bp End 100,151,227 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte bronchial epithelial cell right uterine tube spleen epithelium of nasopharynx appendix blood trabecular bone nasal epithelium palpebral conjunctiva Top expressed in blood epithelium of stomach granulocyte lip pyloric antrum fetal liver hematopoietic progenitor cell mucous cell of stomach tibiofemoral joint molar mesenteric lymph nodes More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding oxidative phosphorylation uncoupler activity transmembrane transporter activity Cellular component cytoplasm membrane mitochondrial membranes mitochondrial inner membrane integral component of membrane mitochondrion Biological process positive regulation of cell death response to hypoxia response to superoxide response to fatty acid female pregnancy cellular response to amino acid starvation negative regulation of insulin secretion involved in cellular response to glucose stimulus ageing negative regulation of apoptotic process response to glucose regulation of mitochondrial membrane potential liver regeneration cellular response to hormone stimulus cellular response to insulin stimulus cellular response to glucose stimulus response to cold mitochondrial transmembrane transport adaptive thermogenesis mitochondrial transport proton transmembrane transport positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7351 22228 Ensembl ENSG00000175567 ENSMUSG00000033685 UniProt P55851 P70406 RefSeq (mRNA) NM_003355 NM_011671 RefSeq (protein) NP_003346 NP_001368872 NP_001368873 NP_001368874 NP_001368876 NP_001368877 NP_001368878 NP_001368879 NP_035801 Location (UCSC) Chr 11: 73.97 – 73.98 Mb Chr 7: 100.14 – 100.15 Mb PubMed search
Wikidata
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Uncoupling protein 2 (mitochondrial, proton carrier), also known as UCP2, is a human gene.

See also

• Uncoupling protein

Further reading

• Arsenijevic D, Onuma H; et al. (2000). "Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production". Nature Genetics. 26 (Dec): 435–9. doi:10.1038/82565. {{cite journal}}: Explicit use of et al. in: |author= (help)
• Bai Y, Onuma H, Bai X; et al. (2005). "Persistent nuclear factor-KB activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production". J Biol Chem. 280 (May 13): 19062–9. doi:10.1074/jbc.M500566200. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.