Gluconate 2-dehydrogenase (acceptor)

In enzymology, a gluconate 2-dehydrogenase (acceptor) (EC 1.1.99.3) is an enzyme that catalyzes the chemical reaction

D-gluconate + acceptor $\rightleftharpoons$ 2-dehydro-D-gluconate + reduced acceptor

Thus, the two substrates of this enzyme are D-gluconate and acceptor, whereas its two products are 2-dehydro-D-gluconate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is D-gluconate:acceptor 2-oxidoreductase. Other names in common use include gluconate oxidase, gluconate dehydrogenase, gluconic dehydrogenase, D-gluconate dehydrogenase, gluconic acid dehydrogenase, 2-ketogluconate reductase, D-gluconate dehydrogenase, 2-keto-D-gluconate-yielding, and D-gluconate:(acceptor) 2-oxidoreductase. This enzyme participates in pentose phosphate pathway. It employs one cofactor, FAD.

References

• Matsushita K, Shinagawa E, Ameyama M (1982). "D-Gluconate dehydrogenase from bacteria, 2-keto-D-gluconate-yielding, membrane-bound". Methods. Enzymol. 89 Pt. D: 187–93. PMID 6815420.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Ramakrishnan T and Campbell JJR (1955). "Gluconic dehydrogenase of Pseudomonas aeruginosa". Biochim. Biophys. Acta. 17: 122–127. doi:10.1016/0006-3002(55)90326-7.

External links

The CAS registry number for this enzyme class is Template:CAS registry.