WASL (gene)

WASL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FF3, 2LNH, 2VCP, 4CC2, 4CC7
Identifiers
Aliases	WASL, N-WASP, NWASP, WASPB, WASL (gene), Wiskott-Aldrich syndrome like, WASP like actin nucleation promoting factor
External IDs	OMIM: 605056; MGI: 1920428; HomoloGene: 136779; GeneCards: WASL; OMA:WASL - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q31.32 Start 123,681,943 bp End 123,749,003 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 A3.1 Start 24,613,804 bp End 24,665,008 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus lateral nuclear group of thalamus jejunal mucosa Brodmann area 23 skin of thigh mucosa of colon mucosa of sigmoid colon renal medulla trigeminal ganglion postcentral gyrus Top expressed in medullary collecting duct Region I of hippocampus proper renal corpuscle ciliary body retinal pigment epithelium conjunctival fornix vestibular membrane of cochlear duct facial motor nucleus Paneth cell Epithelium of choroid plexus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase regulator activity protein binding actin binding Cellular component cytoplasm endocytic vesicle membrane cytosol plasma membrane actin cytoskeleton actin cap extracellular exosome cytoskeleton nucleus lamellipodium cytoplasmic vesicle Biological process negative regulation of membrane tubulation regulation of transcription, DNA-templated response to bacterium Fc-gamma receptor signaling pathway involved in phagocytosis vesicle organization actin filament organization ephrin receptor signaling pathway regulation of nitric-oxide synthase activity positive regulation of Arp2/3 complex-mediated actin nucleation transcription, DNA-templated regulation of protein localization cell division vesicle budding from membrane positive regulation of clathrin-dependent endocytosis vesicle transport along actin filament cell cycle actin polymerization or depolymerization spindle localization negative regulation of lymphocyte migration positive regulation of filopodium assembly actin cytoskeleton organization membrane organization dendritic spine morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8976 73178 Ensembl ENSG00000106299 ENSMUSG00000029684 UniProt O00401 Q91YD9 RefSeq (mRNA) NM_003941 NM_001167745 NM_028459 RefSeq (protein) NP_003932 NP_001161217 NP_082735 Location (UCSC) Chr 7: 123.68 – 123.75 Mb Chr 6: 24.61 – 24.67 Mb PubMed search
Wikidata
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Wiskott-Aldrich syndrome-like, also known as WASL, is a human gene.