Talk:Doxycycline

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what?

what exactly does Doryx do? I got it because of cullulitis or something after my ingrown toenail was removed.70.161.245.18 03:55, 27 May 2007 (UTC)[reply]

IUPAC name IS wrong

I agree, the IUPAC name IS wrong, mainly because the compound has only 2 carbonyl groups (and two enolic ones), and therefore could not possibly be called a -trione.

unusual warning?

On the side of the bottle of this drug there's an unusual warning: Do not lie down for 30 minutes after taking this medication. Anyone know what that's about (and particularly how serious it is)? --Junkyard prince 11:08, 8 October 2005 (UTC)[reply]

Lying down after taking doxycycline can cause pain similar to heartburn. There is some evidence to suggest that if this occurs regularly over a long period of time, oesophagal damage similar to Barrett's Esophagus can occur. For the small amount of effort it takes, it is a wise precaution to obey.Rossheth 14:28, 27 November 2005 (UTC)[reply]

This warning is probably because of the possible risk of the pill getting stuck in your esophagus. This has been known to happen specifically with doxycycline just because the pill is so large. There have been reports of cases of teenagers who were taking doxycycline for acne having esophageal damage and tears because the pill was stuck for longer than 24 hours.--Beezer137 (talk) 18:24, 20 January 2008 (UTC)[reply]

Doxycycline in Vibrio Cholera

There is no mention that doxycycline and tetracycline are the drugs of choice for cholera in adults.

Probably because most doctors who contribute to this English wikipedia are from English-speaking countries (USA, UK) where fortunately cholera is infrequently encountered. A quick search indicates they do indeed have a role (some articles highlight onset of resistance to the group). However whilst they help reduce the severity of an episode, the more important "drug" is actually the provision of oral rehydration fluids, intravenous fluids on occasion and of course public health measures to both prevent and contain outbreaks. I'll add a section to the main tetracycline antibiotics article.David Ruben ^Talk 14:38, 17 March 2006 (UTC)[reply]

Tooth Discoloration?

Hello,

How likely is it that tooth discoloration will occur. My dermatologist reccommended I take this for atleast two months! I do not have severe acne but have a small cyst...very minor under the skin. Any information would be greatly appreciated before I begin taking this!

above added by User:24.73.242.194 at 18:51, 3 May 2006

Firstly please note it is policy to sign talk page entries, the easiest method is to use 4 tildes (~~~~) which will add your name, date & time for you.

Tetracyclines stain teeth and restrict tooth development by binding to the calcium as the tooth forms - hence the restriction on their use in children under 12. As far as I am aware, beyond this age, no perminant tooth staining occurs.
All acne treatments (whether benzoyl peroxide or any of the oral or topical antibiotics) generally take 4-6 weeks to start to work well and 6-8 weeks to have their main effect, hence the typical length of treatment you have been prescribed.
Cystic acne is a more severe form of acne than just simple surface pimples, although sounds as if you are lucky to have only to a limited extent. David Ruben ^Talk 19:12, 3 May 2006 (UTC)[reply]

I agree. No tooth discoloration occurs after the age when your teeth have fully grown and developed, after about age 12.--Beezer137 (talk) 18:28, 20 January 2008 (UTC)[reply]

treatment for blepharitis?

I was prescribed 100mg doxycycline tablets on a one-month course to treat what my eye specialist considers to be stubborn blepharitis. He said it wasn't known why doxycycline was effective, but that it seemed to be. Does anyone know why? Nbertram 12:16, 12 September 2006 (UTC)[reply]

blood thinners

do you think it is good to take at the same time as blood thinners? Above posted User:66.25.164.66 on 21:23, 6 May 2006

Please note it is policy to sign talk-page entries - done for you by using 4 tildes ~~~~
Whilst (as my British National Formulary indicates) studies fail to demonstrate an interaction with broad-spectrum antibiotics, common experience in anticoagulation clinics is that the INR may be altered. Given that most antibiotics therefore may have an interaction (amoxicillin, quinolones, macrolides, trimethoprom, sulphonamides etc) the question is not whether it is "good" to take, presumably there is a need to take an antibiotic else "bad" might occur. So presuming antibiotic is necessary, the issue is whether one needs the INR rechecking after a few days to adjust the anticoagulant dosage whilst taking the antibiotic:
- Hence worthwhile checking back with the doctor to ensure that they did not forget about possible interactions and whether an additional anti-coagulation clinic check is required...
- Patient should also remember to advise the anti-coag clinic that they are on antibiotic and how long its course is for (if teh anti-coagulant dose required changing then a further rcheck may be required few days after finishing the antibiotic). David Ruben ^Talk 22:22, 6 May 2006 (UTC)[reply]

Expand article

I would like to see more info on uses...whoever knows more about this medicine, please expand the article.--AAAAA 16:44, 2 August 2006 (UTC)[reply]

By and large, all members of the tetracyclines have similar activity and thus clinical use. Certainly the longer acting members are more useful for those on long courses (acne, malaria prevention) if only because aid medication compliance. Main discussion of use needs be in tetracycline antibiotics, with just brief outline and any specific points or distinguishing features of use appearing for each member of the group. David Ruben ^Talk 18:15, 2 August 2006 (UTC)[reply]

Why is Doxycyline use for malaria

Malaria is caused by an acutal parasite not a bacteria. So how can it be effective? Is it the fact that it is semisynthetic and it possesses the properties of both antbiotic and antiparasitic?

SPC Bevers Combat Medic User:65.74.212.241 07:00, 6 November 2006

Good question - yes clearly by acting as antiparasite, but the question is really whether this is a similar mechanism to its antibacterial activity. Recent paper confirms the mecahism (blocks a plasmid in the malaria from later being able to divide) and whilst the paper I've cited in the article was about specifically about Doxycycline, the authors presume this is a class effect by which other tetracycline antibiotics also have anti-malaria effects. David Ruben ^Talk 14:38, 6 November 2006 (UTC)[reply]

Sexual Side effects?

Are there any documented cases of sexual side effects with this medication? At the pharmacy where I work, I looked the info packet and saw none. However, I seem to be experiencing the symptoms of ED only on days when I take this mass. PowderedToastMan 08:18, 7 February 2007 (UTC)[reply]

Other effects?

When taking doxycycline for malaria prevention (I remember its brand name at the time as "Doximol", though I can find no other reference other than a single entry in the Indian Trademarks index) I remember it giving me particularly vivid dreams. Are there any listed psychoactive side effects of this substance?

need some info..

i've been using doxycycline for almost a year and a half for my acne and it has started to lose its effect on treating my acne. My friend has told me about minocycline and that it has really work well for him and i was wondering if the change in medication would help? I went to see a pharmacist today and he told me that 90% of doxycycline and minocycline are the same. Also, i wanted some opinion on GERD and barrnetts diesase. During the prolong period i had taken doxycycline, there would be theses days where i thought i would have taken the medication wrong and it had gotten stuck in my throat and released. I would have the pain in my throat all day, that would really bother me, and this would happen i would say at least twice a month, do i need to be worried about anything???? Also, are there any side effects or things i need to be worried about for prolonged used of doxycycline??

If you specifically have an issue with the pill getting stuck, I would suggest you change to a different one. This issue is specifically because of how large the pill is, and there have been reports of esophageal rupture with this as well. The abstract is available on the web.[1]

Also, even though the pharmacist is right about how similar doxycycline and minocycline are, it happens all the time that for a particular individual, one medication will work while another does not. Acne can be a problem where you may have to keep switching medications and trying out different things for quite a while.--Beezer137 (talk) 18:41, 20 January 2008 (UTC)[reply]

Names

Sorry if this sounds really stupid, but is there a difference between Doxycycline and Doxycycline Hyclate? 88.105.14.145 18:08, 15 August 2007 (UTC)[reply]

combination of doxycycline with lactic acid bacillus

why combination of doxycycline with lactic acid bacillus is used? —Preceding unsigned comment added by 59.181.100.28 (talk) 08:12, 19 September 2007 (UTC)[reply]

Veterinary usage?

Could someone speak to the usage of Doxycycline in veterinary medicine, specifically animal dosing and side effects?