Deplorable Word
The Deplorable Word, as used in The Magician's Nephew, by British author C. S. Lewis, is a magical weapon of last resort in Charn, the home world of the character Queen Jadis. All life besides the user's is apparently extinguished by its power.
Apparently, Charn had been engulfed in a civil war one thousand years before the events of The Magician's Nephew took place (Charn years at least; as time works differently in this world and Narnia, time may also work differently in Charn, but this is never said). Jadis, the Queen, was challenged by her sister, who led an army against her; Jadis, her entire army destroyed, used the word, which destroyed all other life in her world, to keep her sister from the throne.
Though it was apparently known in Charn that the Deplorable Word existed, it was forbidden to try to discover it or use it; Jadis mentions vaguely that it was difficult for her to discover it, and also says that although her sister knew that Jadis knew the Word, she did not expect the Queen to actually use it. What the Word actually is, is never said; probably this is because if Jadis told anybody what the word was, it would simply cause another mass death throughout her world. (How she was told the Word is not explained.)
It could be hypothesized to be a reference by Lewis to nuclear devices. This is given credence by the Word's destructiveness and that Jadis sister felt that Jadis would never use it; also, at the end of the book, Aslan warns the characters Diggory Kirke and Polly Plumber that, though their world is not as terrible as Charn was, it was still possible for just as destructive a weapon as the Word to be used here.