FOSB
Template:PBB FBJ murine osteosarcoma viral oncogene homolog B (also known as FOSB or FosB) is a human gene.[1]
Delta FosB
Delta FosB is a truncated splice variant of FosB. Delta FosB has been implicated in the development of drug addiction and control of the reward system in the brain.[2]
Role in Cocaine Use
"Delta FosB" levels have been found to increase upon the use of cocaine. Each subsequent dose of cocaine will continue to increase the levels of Delta FosB with no ceiling of tolerance. Increasing the levels of Delta FosB has lead to increases in "Brain-Derived Neurotrophin" (BDNF) levels, which in turn will increase the number of dendritic branches and spines present on neurons involved with the Nucleus Accumbens and Pre-frontal Cortex areas of the brain. This change can be identified rather quickly, and may be sustained weeks after the last dose of the drug. This consequence of cocaine use may attribute to the idea of sensitization presented with the drug.
See also
References
- ^ "Entrez Gene: FOSB FBJ murine osteosarcoma viral oncogene homolog B".
- ^ Werme M, Messer C, Olson L; et al. (2002). "Delta FosB regulates wheel running". J. Neurosci. 22 (18): 8133–8. PMID 12223567.
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Further reading
External links
- FOSB+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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