Amorolfine

{{drugbox | IUPAC_name = (2R,6S)-2,6-dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholine | image = Amorolfine.svg | CAS_number = 78613-35-1 | ATC_prefix = D01 | ATC_suffix = AE16 | PubChem = 54260 | DrugBank = | C=21|H=35|N=1|O= | molecular_weight = 317.509 g/mol | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | pregnancy_AU = | pregnancy_US = | pregnancy_category= | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = }} Amorolfine (or amorolfin), is an allylamine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes.

Marketed as Curanail, Loceryl, Locetar, and Odenil, Amorolfine is commonly available in the form of a Nail Lacquer, containing 5% Amorolfine as the active ingredient. It is currently available over the counter in the UK, having recently been re-classified from prescription-only status.

Amorolfine exhibits a broad spectrum of action, meaning that it kills a wide variety of different fungi, and when used as directed can actually cure the infection for a majority of sufferers.