Jump to content

Bcl-xL

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by 124.120.2.223 (talk) at 07:29, 3 March 2009. The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Bcl-xl is a transmembrane molecule in the mitochondria. It is involved in the signal transduction pathway of the FAS-L. It is one of several anti-apoptotic proteins which are members of the Bcl-2 family of proteins. It has been implicated in the survival of cancer cells. "Bcl-xl" stands for "Basal cell lymphoma-extra large". Other Bcl-2 proteins include Bcl-2, Bcl-w, Bcl-xs, and Mcl-1 It has been found that it spurred mitochondrial elongation and sped up fission and fusion, and without it stumpy and seemingly less energy efficient.[1]

File:Signal transduction pathways.jpg
Overview of signal transduction pathways


  1. ^ [es about mitochondrial 'growth spurts' Physorg:New Clues about mitochondrial growth spurts]